Application of 956010-88-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 956010-88-1, name is 1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile, molecular formula is C7H4N4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
The above-obtained 3-chloromethyl)-2-fluoropyridine and 5.44 g3-cyano-1H-pyrazolo[3,4-b]pyridine was dissolved in 110 mL of DMF, 10.42 g of K2CO3 was added, N2 was protected, and the mixture was stirred at room temperature for 30 min, and then reacted overnight at 40 C. under the protection of N2. The reaction was monitored by TLC and the reaction was complete. After adding 200 mL of water, the mixture was stirred, extracted with ethyl acetate (110 mL*3), washed with saturated brine (60 mL), dried over anhydrous MgSO4, suction filtered, and the solvent was distilled off under reduced pressure. Column chromatography yielded 7.54 as a white solid. g, yield 78.9%.
According to the analysis of related databases, 956010-88-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; The Chinese People’s Liberation Army Military Academy Of Medical Sciences Poison Pharmaceutical Institute; Li Song; Zheng Zhibing; Lin Feng; Gong Zehui; Lu Xinqiang; Zhou Xinbo; Zhong Wu; Xiao Junhai; Xie Yunde; Li Xingzhou; Wang Xiaokui; (24 pag.)CN107964011; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem