Electric Literature of 10128-71-9 ,Some common heterocyclic compound, 10128-71-9, molecular formula is C6H5NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: According to a typical procedure, in a 100 mL round bottom flask, 2 g (13.06 mmol) of the acid 16 were added to 30 mL of acetone. The mixture was alkalized with a 20% NaOH solution to completely dissolve the acid. 0.82 mL (13.1 mmol, 1.87 g) of commercial CH3I were then added and the reaction mixture was stirred at room temperature for about 4 h. The solvent was moved off in a rotary evaporator and the residue was taken up in a small volume of distilled water (30 mL), acidified with 2 M HCl and stirred with slight heating for about 30 min. After concentration of the solution to about a half volume in a rotary evaporator, the formed solid product was collected by filtration, and a white residue was obtained. To remove the NaCl present as an impurity, the residue was treated with a small volume of absolute ethanol (15 mL), the suspension was filtered, and to the filtrate was added an excess of diethyl ether, obtaining the precipitation of the desired compound. This was collected and dried under vacuum.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10128-71-9, 3-Hydroxyisonicotinic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Brun, Paola; Dean, Annalisa; Di Marco, Valerio; Surajit, Pathak; Castagliuolo, Ignazio; Carta, Davide; Ferlin, Maria Grazia; European Journal of Medicinal Chemistry; vol. 62; (2013); p. 486 – 497;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem