Synthetic Route of 89856-44-0 ,Some common heterocyclic compound, 89856-44-0, molecular formula is C7H9BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: A mixture of aromatic aldehyde (1mmol), amidine (1mmol) and isocyanide (1mmol) was taken in 2 mL acetonitrile. Then, the catalyst bromodimethylsulfonium bromide (0.022 g, 0.1mmol) was added into it and the reaction mixture was kept for stirring at room temperature till the completion of the reaction as indicated by TLC. The solid product came out slowly which was filtered through a Buchner funnel and the solid precipitate was washed with acetonitrile. Finally it was dried under reduced pressure.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 89856-44-0, 5-Bromo-4,6-dimethylpyridin-2-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Khan, Abu T.; Sidick Basha; Lal, Mohan; Tetrahedron Letters; vol. 53; 17; (2012); p. 2211 – 2217;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem