Shan, Zhenwei published the artcileDiscovery of potent dipeptidyl peptidase IV inhibitors derived from β-aminoamides bearing substituted [1,2,3]-triazolopiperidines for the treatment of type 2 diabetes, Product Details of C5H6BNO2, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(6), 1731-1735, database is CAplus and MEDLINE.
A series of novel [1,2,3]-triazolopiperidine derivatives I (R = H, Me, CHF2, CF3, CO2Me, CONH2, CONMe2, Ph, 4-F-C6H4, 4-Cl-C6H4, 4-CF3-C6H4, 4-CN-C6H4, 3-CO2Me-C6H4, 4-CONH2-C6H4, 4-CONMe2-C6H4,4-CO2H-C6H4, 4-SO2Me-C6H4, 4-Pyr, 2-Pyr, 2-furanyl, 3-furanyl, 2-thienyl, 3-thienyl, 4-oxazolyl) were synthesized and evaluated as inhibitors of dipeptidyl peptidase IV (DPP-4) for the treatment of type 2 diabetes, most of the compounds exhibited excellent in vitro potency (IC50 <50 nM) against DPP-4. Among these, compound I (R = CF3) with potent in vitro activity against DPP-4 and good pharmacokinetic profiles exhibited pronounced in vivo efficacy in an oral glucose tolerance test (OGTT) in ICR mice. On the base of these properties, compound I (R = CF3) was selected as a potential new candidate for the treatment of type 2 diabetes.
Bioorganic & Medicinal Chemistry Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C15H23BO2, Product Details of C5H6BNO2.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem