Shapiro, Anna published the artcileIn vivo and in vitro activity by diverse chelators against Trypanosoma brucei brucei, Product Details of C11H10N4, the publication is Journal of Protozoology (1982), 29(1), 85-90, database is CAplus and MEDLINE.
A system of prescreens and a screen was developed to select chelators as potential drugs against T. brucei brucei EATRO 110. The chelators tested were nearly all com. available, low mol., and had a moderate to high affinity for Fe(III). Seventy compounds showing heme-sparing or inhibitory activity in a Crithidia fasciculata growth system having excess Fe and minimal hemin were prescreened. Of these, 45 were highly trypanocidal for suspensions of bloodstream T. brucei brucei; criteria of activity here were immobilization, lysis, and loss of infectivity. Eighteen of the chelators highly active in the suspension prescreen were tried in T. brucei brucei-infected mice. Thirteen of these chelators were curative in mice with 24-h infections, i.e., they allowed survival >30 days beyond the untreated controls, caffeic acid [331-39-5], neocuproine [484-11-7], and 2-pyridinecarboxaldehyde-2-pyridylhydrazone [2215-33-0] cure 5 out of 5 mice after an i.v. dose of 100 mg/kg. salicylaldehyde thiosemicarbazone [5351-90-6] Cured 5 of 5 mice at an i.p. dose of 500 mg/kg. Lesser activity was shown by several other chelators.
Journal of Protozoology published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C13H18BFO2, Product Details of C11H10N4.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem