The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 160590-36-3, name is 2-Methoxy-3-nitro-4-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. name: 2-Methoxy-3-nitro-4-methylpyridine
BrSodium acetate (365 g, 5.37 mol) was added to a stirred solution of 2-methoxy-4-methyl-3-nitropyridine (250 g, 1.49 mol) in acetic acid (1.5 L) at ambient temperature, then bromine (639g, 4.00 mol) was added and the reaction was heated at 80 C for 12 h. The mixture was then quenched by the addition of 10% aqueous NaOH (1.5 L) and saturated aqueous Na2SO3 (1.5 L) at 0 C. The resulting solid was collected by filtration and washed with water, dried under vacuum to give the title compound (302 g, 82.2% yield) as a light yellow solid. ?H NMR (400MHz, DMSO-d6): oe 8.25 (s, 1 H), 3.94 (s, 3 H), 2.29 (s, 3 H).
With the rapid development of chemical substances, we look forward to future research findings about 160590-36-3.
Reference:
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ADLER, Marc; BURDICK, Daniel, J.; CRAWFORD, Terry; DUPLESSIS, Martin; MAGNUSON, Steven; NASVESCHUK, Christopher, G.; ROMERO, F. Anthony; TANG, Yong; TSUI, Vickie Hsiao-Wei; WANG, Shumei; (276 pag.)WO2016/123391; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem