Share a compound : 2-Methylisonicotinaldehyde

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,63875-01-4, its application will become more common.

Reference of 63875-01-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 63875-01-4, name is 2-Methylisonicotinaldehyde. A new synthetic method of this compound is introduced below.

Example 38: Preparation of 4-Chloro-N-{5-chloro-2-fhvdroxy-(2-methyl-pyridin-4- yl)-methyl]-pyridin-3-yl)-N-methoxymethyl-3-trifluoromethyl benzenesulfonamide; [00427] To a stirred solution of N-(2-bromo-5-chloro-pyridin-3-yl)-4-chloro- N-methoxymethyl-3-trifluoromethyl-benzenesulfonamide (494 mg, 1.0 mmol) in anhydrous THF (10 mL) was added 2 M isopropylmagnesiumchloride in THF (1.20 mL, 2.4 mmol) at -40 °C. After 5 minutes dry ice-acetone bath was replaced with a ice water bath and stirred at 0 °C for 1 h. Solid 2-methyl-pyridine-4- carbaldehyde (327 mg, 2.7 mmol) was added in one portion and the progress of EPO the reaction was followed by LCMS. The reaction mixture was warmed to room temperature and stirred overnight. It was then quenched with saturated aqueous NH4CI (2 mL), and extracted with EtOAc. The combined extracts were dried (Na2SO4), filtered and concentrated under reduced pressure to provide the desired product which was utilized in the following step without further purification. MS m/z: 536.0 (M+H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,63875-01-4, its application will become more common.

Reference:
Patent; CHEMOCENTRYX, INC.; WO2006/76644; (2006); A2;,
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