With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.80827-67-4, name is 1-(3-Methoxypyridin-2-yl)piperazine, molecular formula is C10H15N3O, molecular weight is 193.2456, as common compound, the synthetic route is as follows.Formula: C10H15N3O
Example 5d 3-[3-[(3-Methoxy-2-pyridinyl)-1-piperazinyl]propyl]-5-nitro-1H-indole. (5) A mixture of 3-(3-bromopropyl)-5-nitro-1H-indole (4) (0.88 g, 3.11 mmol), potassium carbonate (0.43 g, 3.11 mmol), potassium iodide (0.52 g, 3.11 mmol) and 1-(3-methoxy-2-pyridinyl)piperazine (1) (0.60 g, 3.11 mmol) in 50 mL of acetonitrile was heated to reflux for 5 h. The mixture was cooled, filtered and concentrated. The residue was purified by flash column chromatography with 5% methanol in dichloromethane as eluant to give the title compound (1.2 g, 99%) as a yellow foam; 1 H NMR (DMSO-d6, 300 MHZ) delta 8.54 (d, J=2.2 Hz, 1H), 7.97 (dd, J=2.2, 9.9 Hz, 1H), 7.77(m, 1H), 7.50 (d, J=9.0 Hz, 1H), 7.44 (s, 1H), 7.24 (d, J=7.75 Hz, 1H), 6.90 (m, 1H), 3.78 (s, 3H), 3.33 (br s, 2H), 2.80 (t, J=7.3 Hz, 2H), 1.93 (m, 2H); IR(KBr) 3300, 1520, 1330, 1240 cm-1; MS (m/e) 395 (M+).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,80827-67-4, 1-(3-Methoxypyridin-2-yl)piperazine, and friends who are interested can also refer to it.
Reference:
Patent; Bristol-Myers Squibb Company; US5521188; (1996); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem