Related Products of 879488-53-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 879488-53-6, name is 1-(6-Bromo-3-pyridyl)-4-methylpiperazine, molecular formula is C10H14BrN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Under argon protection, a solution of compound B (1.3 g, 5.08 mmol) in tetrahydrofuran (20 ml) was cooled to -78 degrees Celsius, and n-butyllithium (2.5 M, 3 ml, 7.62 mmol) was slowly added dropwise. After the dropwise addition was completed, stirring was continued for 10 minutes, and tributyltin chloride (2.48 g, 7.62 mmol) was added.The reaction solution was slowly warmed to room temperature, quenched by adding potassium fluoride, and concentrated under reduced pressure. The crude product was purified by Combi-flash column chromatography [DCM: MeOH = 100: 0 to 95: 5] to obtain compound Z-1-1. (1.03 g, 45%).
According to the analysis of related databases, 879488-53-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Zhou Fusheng; Shi Xiaoyong; Huang Dong; Tang Wangqi; Wang Shengyuan; Zhao Jinzhu; Qiao Changjiang; Chen Xi; Lan Jiong; (28 pag.)CN110256446; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem