Electric Literature of 1000341-55-8 ,Some common heterocyclic compound, 1000341-55-8, molecular formula is C7H4ClIN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
a) Preparation of intermediate 10A stirred solution of 6-chloro-3-iodo-5-azaindole (1.00 g, 3.56 mmol) in DMF (35 ml) at 0 C, was treated with sodium hydride (60%> in mineral oil, 0.17 g, 4.31 mmol). After stirring at 0 C for 10 minutes, the mixture was treated with p-toluenesulfonyl chloride (0.75 g, 3.95 mmol), then warmed to ambient temperature over 30 minutes. The reaction was quenched by the addition of water, then partitioned between EtOAc and dilute aqueous sodium bicarbonate solution. The organic phase was washed with brine, dried over Na2SO4 and concentrated in vacuo. The residue was purified by column chromatography on silica gel, eluting with a mixture of EtOAc and cyclohexane (0: 1 to 6:4 by volume), to afford the desired product as a white solid (1.18 g, 76%).LCMS (Method B): Rt= 4.19 min, m/z [M+H]+= 433/435
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1000341-55-8, 6-Chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; HYND, George; TISSELLI, Patrizia; CLARK, David, Edward; KULAGOWSKI, Janusz, Jozef; MACLEOD, Calum; MANN, Samuel, Edward; PANCHAL, Terry, Aaron; PRICE, Stephen, Colin; MONTANA, John, Gary; WO2015/44267; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem