The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 67625-36-9, name is Ethyl 5-chloroimidazo[1,2-a]pyridine-2-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. name: Ethyl 5-chloroimidazo[1,2-a]pyridine-2-carboxylate
A mixture of the compound (1.28 g) obtained in (1), 4-chlorophenylboronic acid (1.78 g), tris(dibenzylidenacetone)dipalladium (0) chloroform adduct (0.34 g), 1,3-bis(2,6-diisopropylphenyl) imidazolium chloride (0.5 g), cesium carbonate (11.2 g) and dioxane (50 mL) was stirred for 24 hours at 80C. The reaction solution was concentrated under reduced pressure, and ethyl acetate was added to the residue, which was then Celite filtered. Water was added to the filtrate, which was then extracted with ethyl acetate. The extract was washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography and recrystallized from diisopropyl ether to obtain ethyl 5-(4-chlorophenyl)imidazo[1,2-a]pyridine-2-carboxylate (830 mg) as colorless crystals. 1H-NMR (CDCl3, 400MHz); delta 1.42 (3H, t, J=7.2Hz), 4.44 (2H, q, J=7.2Hz), 6.81 (1H, d, J=6.8Hz), 7.34 (1H, m), 7.56 (4H, m), 7.70 (1H, d, J=9.2Hz), 8.18 (1H, s)
With the rapid development of chemical substances, we look forward to future research findings about 67625-36-9.
Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1849465; (2007); A1;,
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