In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7579-20-6, name is 3-Aminoisonicotinic acid, the common compound, a new synthetic route is introduced below. category: pyridine-derivatives
Preparation 19 2-Methyl-3-oxa-1,7-diaza-naphthalen-4-one A mixture of 3-aminopyridine-4-carboxylic acid (3.38 g, 24.5 mmol), acetic anhydride (15 mL), and sulfuric acid (3 drops) was refluxed 4 hours. The reaction was cooled and carefully quenched with solid sodium bicarbonate. The mixture was filtered through Celite.(R). (trademark). The filtrate was extracted with ethyl acetate. This organic phase was washed with brine, dried over magnesium sulfate and concentrated to give 2-methyl-3-oxa-1,7-diaza-naphthalen-4-one (1.95 g, 49percent) as a brown crystalline material. 1H NMR delta9.00 (s, 1 H), 8.78 (d, J=5 Hz, 1 H), 7.96 (d, J=5 Hz, 1 H), 2.52 (s, 3 H). The product was suitable for use without further purification.
The synthetic route of 7579-20-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Pfizer Inc; US6323208; (2001); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem