Synthetic Route of 885167-81-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 885167-81-7, name is 6-Bromo-5-methylnicotinaldehyde, molecular formula is C7H6BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Embodiment 69 (E)-2-((6-(3-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylstyryl)-5-methy lpyridin-3-yl)methylamino)-3-hydroxypropanoic acid 69 Synthetic route Synthesis of compound 69-a Compound 15-b (850mg, 2.2mmol) and 6-bromo-5-methyl nicotine aldehyde (300mg, 1.5mmol) were dissolved in a mixed solvent of 1,4-dioxane (20mL) and water (2mL), followed by addition of [1,1′-bis(diphenylphosphino)ferrocene]palladium dichloride (30mg, 0.03mmol) and sodium carbonate (397mg, 3.7mmol). After the reaction system was purged three times with nitrogen, the reaction solution was heated to 80C and stirred for 12 hours. The reaction solution was cooled to room temperature and evaporated under reduced pressure. The residue was purified by silica gel column chromatography (petroleum ether: ethyl acetate = 5:1) to give compound 69-a as a yellow solid (220mg, yield 40%). LC-MS (ESI): m/z = 372 [M+H]+.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 885167-81-7, 6-Bromo-5-methylnicotinaldehyde.
Reference:
Patent; Guangzhou Maxinovel Pharmaceuticals Co., Ltd.; WANG, Yuguang; XU, Zusheng; WU, Tianzhi; HE, Min; ZHANG, Nong; (113 pag.)EP3483142; (2019); A1;,
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