With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.202348-55-8, name is 6-Methylimidazo[1,2-a]pyridine-2-carbaldehyde, molecular formula is C9H8N2O, molecular weight is 160.1726, as common compound, the synthetic route is as follows.Computed Properties of C9H8N2O
A solution of 3-methoxy-/V-((6-methylimidazo[1 ,2-a]pyridin-2-yl)methylene)aniline in ethanol was prepared by heating a solution of 6-methylimidazo[1 ,2-a]pyridine-2-carbaldehyde (0.160 g; 0.999 mmol) and 3-methoxyaniline (0.1 13 mL; 1.009 mmol) in ethanol (0.5 mL) at 65 C for 24 h. The formation of the imine was quantitative and the solution was used without further purification. ESI/APCI (+): 266 (M+H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,202348-55-8, 6-Methylimidazo[1,2-a]pyridine-2-carbaldehyde, and friends who are interested can also refer to it.
Reference:
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN; BARDIOT, Dorothee; CARLENS, Gunter; DALLMEIER, Kai; KAPTEIN, Suzanne; McNAUGHTON, Michael; MARCHAND, Arnaud; NEYTS, Johan; SMETS, Wim; WO2013/45516; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem