Reference of 607373-82-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 607373-82-0, name is 4-Methoxy-5-nitropyridin-2(1H)-one, molecular formula is C6H6N2O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 2.2, 4-Dibromo-5-nitropyridine Phosphorous oxybromide (5.73 g, 20 mmol) was added to a suspension of the product from Step 1 (1.70 g, 10 mmol) in acetonitrile (20 mL) at rt then heated to reflux for 3 h. The reaction mixture was cooled and carefully poured onto ice and sat. aq. K2C03 then extracted with EtOAc. The organic extracts were combined, washd with water and brine, dried (MgS04), filtered and concentrated to dive the title compound (2.1 g, 75 %) as a dark solid.
According to the analysis of related databases, 607373-82-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXO GROUP LIMITED; WO2005/37197; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem