With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5683-33-0, name is 2-(Dimethylamino)pyridine, molecular formula is C7H10N2, molecular weight is 122.17, as common compound, the synthetic route is as follows.Recommanded Product: 5683-33-0
A solution of 5-tert-butyl-2-(2-hydroxyethoxy)-1-nitrobenzene (0.401 g, 1.68 mmol), di-tert-butyl dicarbonate (0.46 mL, 2.0 mmol) and dimethylaminopyridine (0.006 g, 0.05 mmol) in CH2Cl2 (15 mL) was stirred at room temp. for 30 min, at which time TLC indicated consumption of starting material. The resulting mixture was washed with water (20 mL), dried (MgSO4) and concentrated under reduced pressure. The residue was purified by column chromatography (3% MeOH/97% CH2Cl2) to give the desired product as a yellow oil (0.291 g, 51%): 1H-NMR (DMSO-d6) ? 1.25 (s, 9H), 1.38 (s, 9H), 4.31 (br s, 4H), 7.27 (d, J=9.2 Hz, 1H) 7.64 (dd, J=2.6, 8.8 Hz, 1H) 7.77 (d,J=2.6 Hz, 1H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,5683-33-0, 2-(Dimethylamino)pyridine, and friends who are interested can also refer to it.
Reference:
Patent; Bayer Corporation; EP1449834; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem