Reference of 65515-26-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 65515-26-6, name is Methyl 2,6-dimethoxynicotinate. A new synthetic method of this compound is introduced below.
Under nitrogen atomosphere, 15 % hexane solution of triethyl aluminium was dropped at 0C to 26 m solution of toluene with 0.6 ml of N,N’-dimethyl-ethan-1,2-diamine, and the mixture was stirred at room temperature for 1 hour. Then, 5 ml solution of toluene with 1 g of 2,6-dimethoxy-nicotinic acid methylester was dropped at room temperature, and the mixture was stirred at 130C for 1 hour. The reaction solution was cooled down under ice temperature, 1M of hydrochloric acid was added, and extracted with ethyl acetate. Ethyl acetate layer was washed with saturated saline solution, dried with anhydrous sodium sulfate. The solvents were distilled outunder reduced pressure to obtain 156 mg of the above compound. ESI-MS Found:m/z 196.1 [M+H]+
At the same time, in my other blogs, there are other synthetic methods of this type of compound,65515-26-6, Methyl 2,6-dimethoxynicotinate, and friends who are interested can also refer to it.
Reference:
Patent; BANYU PHARMACEUTICAL CO., LTD.; EP1726585; (2006); A1;,
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