Reference of 1083169-00-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1083169-00-9, name is 4-Bromo-2-methoxy-6-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows.
A solution of intermediate 6c (0.1M solution in THF, 66 mL,6.6 mmol) was added to a solution of 4-bromo-2-methoxy-6-methylpyridine (CAS: 1083169-00-9; 1.21 g, 6.00 mmol) and Pd(/-Bu3P)2 (140 mg, 0.27 mmol). The reaction mixture was stirred at room temperature for 16 h. The mixture was treated with NH4Cl (sat., aq.) and extracted with EtOAc. The organic layer was dried (Na2S04), filtered and the solvent was evaporated in vacuo. The crude mixture was purified by flash column chromatography (S1O2, (0434) EtOAc in heptane, gradient from 100:0 to 80:20) to afford intermediate 31 (1 g, 54%).
According to the analysis of related databases, 1083169-00-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose Manuel; TRABANCO-SUAREZ, Andres, Avelino; DE LUCAS OLIVARES, Ana Isabel; TRESADERN, Gary John; CONDE-CEIDE, Susana; (212 pag.)WO2019/243528; (2019); A1;,
Pyridine – Wikipedia,
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