The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 41288-96-4, name is 2-Chloro-5-hydroxypyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-Chloro-5-hydroxypyridine
2-Chloro-5-hydroxypyridine (25 g, l93mmol), potassium carbonate (53.3 g, 386 mmol), and methyl iodide (14.5 mL, 223mmol) were combined in a flask of acetonitrile (500 mL, 0.2M) under nitrogen. The reaction mixture was stirred at room temperature overnight and then diluted with water (1L). The reaction mixture was extracted with hexanes (3 x 500 mL). The combined organic layers were washed with brine, dried over sodium sulfate, and concentrated under reduced pressure. This crude residue was purified over a pad of silica eluted with hexanes (400 mL), and the filtrate was concentrated under reduced pressure to give 2- chloro-5-methoxy pyridine as a yellow oil (21.7 g, 78.3%). ‘fl NMR (400MHz, DMSO-c/,,) d 8.13 (d, J = 2.9 Hz, 1H), 7.51- 7.47 (m, 1H), 7.45 – 7.42 (m, 1H), 3.84 (s, 3H); MS (ESI+) m/z 144.1 (M+H)+
With the rapid development of chemical substances, we look forward to future research findings about 41288-96-4.
Reference:
Patent; GENENTECH, INC.; F. HOFFMANN-LA ROCHE AG; CUNNINGHAM, Christian; BEROZA, Paul Powell; CRAWFORD, James John; LEE, Wendy; RENE, Olivier; ZBIEG, Jason Robert; LIAO, Jiangpeng; WANG, Tao; YU, Chen; (208 pag.)WO2020/51099; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem