Adding a certain compound to certain chemical reactions, such as: 1204295-87-3, 2-Bromo-4-(difluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1204295-87-3, blongs to pyridine-derivatives compound. Safety of 2-Bromo-4-(difluoromethyl)pyridine
To a degassed mixture of 4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)benzamide ( 1.5g, 6.07 mmol) and 2-bromo-4-(difluoromethyl)pyridine(1.515g, 7.284 mmol) in dioxane was added Pd2(dba)3(catalytic amount) , X-phos (catalytic amount) and Cs2C03 (3.956g, 12.141 mmol) under ^atmosphere. The mixture was stirred at 100 C overnight. The reaction mixture was cooled to room temperature and filtered. The filtrate was concentrated, and the residue was purified on silic-gel to give N-(4-(difluoromethyl)pyridin-2-yl)-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)benzamide (1.8 g, yield 79%). 1HNMR (400MHz, DMSO-d6): delta= 8.55-8.54 (d, / = 4 Hz, 1 H), 8.39 (s, 1 H), 8.02-8.00 (d, / = 8.0 Hz, 2 H), 7.79-7.77 (d, / = 8.0 Hz, 2 H), 7.34-7.33 (d, / = 4 Hz, 1 H), 7.29-7.01 (t, / = 52 Hz, 1 H), 1.30 (s, 12 H), MS (ESI): M/Z (M+l)=375.16.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1204295-87-3, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; WU, Hao; KIM, Ronald M.; LIU, Jian; GAO, Xiaolei; BOGA, Sobhana Babu; GUIADEEN, Deodialsingh; KOZLOWSKI, Joseph; YU, Wensheng; ANAND, Rajan; YU, Younong; SELYUTIN, Oleg B.; GAO, Ying-Duo; LIU, Shilan; YANG, Chundao; WANG, Hongjian; WO2014/114185; (2014); A1;,
Pyridine – Wikipedia,
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