Electric Literature of 1620-72-0 ,Some common heterocyclic compound, 1620-72-0, molecular formula is C7H6F3N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 2-methyl-6-(trifluoromethyl)pyridine (22.2 g, 138 mmol) in toluene (200 mL) was added mCPBA (23 g, 150 mmol). The reaction mixture was refluxed for 24 h under N2 atmosphere and quenched with saturated NH4CI solution. The resulting mixture was extracted with EtOAc (2 x 150 mL). The combined organic layers were washed with brine, dried over Na2S04, and concentrated in high vacuum. The residue was purified by silica gel chromatography (PE/EtOAc=5/l to 1/1) to give the title compound (5.5 g, yield : 22%); m/z (ES+) : 178 [M + H]
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1620-72-0, its application will become more common.
Reference:
Patent; LEO PHARMA A/S; BLADH, Haakon; FELDING, Jakob; ZHOU, Ding; CAI, Zhen-wei; SØRENSEN, Morten Dahl; WO2015/24878; (2015); A1;,
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