With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.137736-63-1, name is 2-(4-Bromophenoxy)-5-(trifluoromethyl)pyridine, molecular formula is C12H7BrF3NO, molecular weight is 318.09, as common compound, the synthetic route is as follows.name: 2-(4-Bromophenoxy)-5-(trifluoromethyl)pyridine
(a) (E)-Ethyl 3-(l-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)- lH-indol-3-yl)acrylate (3) was prepared as follows: A mixture of compound 1 (Alfe Aesar, 0.5 g, 1.0 eq), compound 2, Cul (0.2 eq), K2C03 (3 eq), and dimethylglycine (Aldrich, 0.1 eq) in DMF (10 mL) was heated at 160 °C for 30 minutes under microwave. The mixture was dissolved in water/EtOAc (20 mL/100 mL). The organic layer was washed with brine, concentrated and purified by column (silica gel, EtOAc/hexane 1/10) to afford compound 3 as a white solid (0.4 g, 40percent): ?-NMR (400MHz, CDC13) ?: 8.42 (s, IH), 7.85 – 7.92 (m, 3H), 7.54 (s, IH), 7.47 – 7.51 (m, 3H), 7.23 – 7.29 (m, 4H), 7.06 (d, IH, 8.8Hz), 6.45 (d, IH, 16Hz), 4.23 (q, 2H, 7.1Hz), 1.29 (t, 3H, 7.2Hz).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,137736-63-1, 2-(4-Bromophenoxy)-5-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.
Reference:
Patent; PURDUE PHARMA L.P.; YAO, Jiangchao; WO2013/64883; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem