Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 144100-07-2, name is 2-Bromo-6-fluoropyridine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C5H3BrFN
2-Bromo-6-fluoropyridine (2 g, 11.36 mmol) and 3-hydroxyoxetane (926.05 mg, 12.50 mmol) were dissolved in anhydrous THF (10 mL), potassium tert-butoxide (1.65 g, 14.66 mmol) was added at 0C, and stirred at 0C for 2 h. The reaction mixture was added into water (20 mL), then extracted with EA (2×20 mL), the organic phase was washed by saturated brine (30 mL), dried over anhydrous sodium sulfate, and the filtrate was concentrated to give 53-1. 1H NMR (400 MHz, CDCl3) delta ppm 7.40 – 7.40 (m, 1H) 7.36 – 7.65 (m,1H) 7.11 (d, J=7.6 Hz, 1H) 5.60 – 5.71 (m,1H) 4.73 – 5.01 (m,2H) 4.60 – 4.79 (m,2H) MS m/z: 230.06 [M+H]+
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Reference:
Patent; Shijiazhuang Sagacity New Drug Development Co., Ltd.; QIAN, Wenyuan; YANG, Chundao; LI, Zhengwei; LI, Jie; LI, Jian; CHEN, Shuhui; (137 pag.)EP3572413; (2019); A1;,
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