Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 195044-14-5, name is 2-Bromo-6-tert-butylpyridine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-Bromo-6-tert-butylpyridine
To a 250 mL three-necked flask was added 3-methoxyphenylboronic acid (3.1 g, 20.0 mmol) K2CO3 (5.8 g, 42.0 mmol), and then a reflux device was set up, and the gas was purged three times in an argon atmosphere. 2-Bromo-6-tert-butylpyridine (3.6 g, 16.8 mmol), solvent ethylene glycol dimethyl ether (30 mL) and distilled water (20 mL) were added. The system was then bubbled with a long needle for 30 min and then tetrakistriphenylphosphine palladium (1.0 g, 0.9 mmol) was added. The system was heated to reflux for 12 h under argon. After the reaction was completed, the system was cooled to room temperature, and ethyl acetate (30 mL EtOAc) was evaporated. 1:100), 2.7 g of colorless oil2-(3-Methoxyphenyl)-6-tert-butylpyridine, yield 67%.
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Reference:
Patent; Chinese Academy Of Sciences Shanghai Organic Chemistry Institute; Huang Zheng; Jia Xiangqing; Guo Le; (26 pag.)CN104804041; (2018); B;,
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