Related Products of 54957-86-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.54957-86-7, name is 2,3-Dichloro-6-methylpyridine, molecular formula is C6H5Cl2N, molecular weight is 162.0166, as common compound, the synthetic route is as follows.
A mixture of 8,1 (1 .70 g, 10,51 mmol), Zn(CN)2 (0.74 g, 6.30 mmol) and Zn (0.031 g, 0,47 mmol) in DMF (10.5 mL) is degassed (B. Van Wagenen, US2003/55085). PdC^dppfj-CHzCIs adduct (0.189 g, 0.231 mmol) is added and the solution is again degassed then is heated at 125C for 5 h. The crude mixture is diluted with EtOAc (150 mL) and the mixture is filtered through diatomaceous earth (washing the cake with EtOAc (25 mL)). The filtrate is washed twice with a mixture of water and saturated NaHC03 solution (3/1 ) and with brine, then dried (Na2S04), filtered and concentrated under reduced pressure. The residue is purified by flash chromatography (10-10Q%EtQAc:Hex) to give 8.2; MS: m/z = 153.1/155.1 (MH+); 1 H NMR (400 MHz, CDCI3) delta ppm 2.60 (s, 3 H), 7.34 (d, J=8.22 Hz, 1 H), 7.73 (d, J=8.61 Hz, 1 H).
Statistics shows that 54957-86-7 is playing an increasingly important role. we look forward to future research findings about 2,3-Dichloro-6-methylpyridine.
Reference:
Patent; UNIVERSITE DE MONTREAL; SIMONEAU, Bruno; CHANTIGNY, Yves; YEH, Jonathan; SAUVAGEAU, Guy; MARINIER, Anne; (94 pag.)WO2019/87129; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem