Synthetic Route of 101990-69-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.101990-69-6, name is 2,6-Dichloropyridine-4-methanol, molecular formula is C6H5Cl2NO, molecular weight is 178.02, as common compound, the synthetic route is as follows.
A solution of (2,6-dichloro-pyridin-4-yl)-methanol (44.5 mg, 0.25 mmol, 1.25 equiv; commercially available) and 1-(4-chloro-3-ethoxy-benzyl)-piperidin-4-ylamine (53.8 mg, 0.20 mmol, 1.2 equiv; intermediate A2) in DMF (2.0 mL) was heated by microwave irradiation to 220 C. for 1 h. Removal of the solvent under reduced pressure and purification by preparative HPLC on reversed phase eluting with a gradient of acetonitrile/water provided 3.2 mg (4%) of the title compound. MS (ISP): 410.3 [M+H]+.
Statistics shows that 101990-69-6 is playing an increasingly important role. we look forward to future research findings about 2,6-Dichloropyridine-4-methanol.
Reference:
Patent; Binggeli, Alfred; Christ, Andreas D.; Maerki, Hans P.; Martin, Rainer E.; US2008/45544; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem