Synthetic Route of 579475-29-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 579475-29-9, name is 5-Bromo-2-cyclopropylpyridine, molecular formula is C8H8BrN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(0.21 g, 1.1 mmol), bis(pinacolato)diboron (0.31 g, 1.2 mmol) and potassium acetate (0.32 g, 3.2 mmol) were suspended in dioxane (10 mL). The slurry was degassed with argon for 10 minutes and then PdCl2X dppf (0.026 g) was added. The reaction mixture was heated to 80 C for 15 h and then, after cooling to RT, filtered through a Celite plug. The filtrate was concentrated to give a black oil that was dissolved in ether and extracted four times with 1.0M sodium hydroxide. The combined yellow water phases were cooled to 10 C, acidified with 2.5M hydrochloric acid to pH 6.5 and then extracted repeatedly with ether. The combined organic phases were dried over anhydrous magnesium sulfate, filtered and concentrated to give 0.27 g (103%) of the title product as a yellow oil that slowly solidified. 1H-NMR suggested a purity of about 60-65% of the required product, the major contaminant being pinacolborane. The crude material was used without further purification.GC-MS mlz 245.2 (M+), 244.2 (M-I);1H-NMR(CDCl3) delta 8.78 (br s, IH), 7.93 (dd, IH), 7.10 (d, IH)5 2.10 (m, IH), 1.34 (s, 12H)5 1.10-1.00 (m, 4H) ppm.
According to the analysis of related databases, 579475-29-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTRAZENECA AB; WO2006/65215; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem