Synthetic Route of 890302-02-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 890302-02-0, name is 2-amino-6-(Trifluoromethyl)nicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.
difluorophenyl)propanoic acid (0.731 g, 2.426 mmol) in DCM (32 mL) was added N- methylmorpholine (0.670 mL, 6.06 mmol) followed by isobutyl chloroformate (0.640 mL, 4.85 mmol). The reaction was then cooled to -20 C (IPA/dry ice) and 2-amino-6- (trifluoromethyl)nicotinic acid (0.50 g, 2.43 mmol) was added. The reaction slurry was allowed to slowly warm to ambient temperature overnight as bath thawed for 18 h. The reaction was heated to reflux for 2 h. Upon cooling to ambient temperature, the reaction was filtered. The filtrate was diluted with EtOAc. The organic layer was washed with saturated sodium bicarbonate, brine, dried (Na2S04) and concentrated in vacuo. The crude product was triturated with hexanes and filtered to give the product which was a mixture due to some racemization as an orange solid (0.41 g, used as is). NMR (500 MHz, CDC ) delta 8.80 – 8.75 (m, 1H), 7.95 – 7.89 (m, 1H), 6.74 – 6.71 (m, 3H), 5.52 – 5.44 (m, 1H), 5.08 – 5.01 (m, 1H), 3.44 – 3.37 (m, 1H), 3.19 – 3.15 (m, 1H), 1.47 – 1.44 (m, 9H)
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 890302-02-0, 2-amino-6-(Trifluoromethyl)nicotinic acid.
Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BABU, Suresh; BELEMA, Makonen; BENDER, John A; IWUAGWU, Christiana; KADOW, John F.; KUMARAVEL, Selvakumar; NAGALAKSHMI, Pulicharla; NAIDU, B. Narasimhulu; PATEL, Manoj; PEESE, Kevin M; RAJAMANI, Ramkumar; SAULNIER, Mark; WANG, Alan Xiangdong; (536 pag.)WO2018/203235; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem