Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1201326-81-9, name is Methyl 5-(methylsulfonyl)picolinate. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of Methyl 5-(methylsulfonyl)picolinate
Compound 3 (8.6 g, 20 mmol) was added to methanol/water (60 mL / 20 mL)And LiOH (3.3 g, 80 mmol). The reaction mixture was stirred at room temperature for 2 hours.The reaction mixture was acidified to pH = 6, and the precipitate was separated by filtration.The filtered precipitate was dissolved in dichloromethane (100 mL) and a catalytic amount of DMF was added.Then, oxalyl chloride (6.8 g, 54 mmol) was slowly added dropwise at 0 C.The temperature was raised to room temperature and held for 2 hours. Then remove the solvent,The mixture was dissolved in CH 2 Cl 2 (100 mL).Et3N (13.8 mL, 108 mmol) was added.Stir for 5 minutes,N,O-Dimethylhydroxylamine hydrochloride (5.3 g, 54 mmol) was added.The reaction was continued to stir at room temperature for 30 minutes.Water (40 mL) was added to the reaction mixture and water was applied sequentially.Wash with saturated brine. The organic phase was collected and dried over anhydrous MgSO4.The solvent was removed to give the product 4 (7.3 g, 82%).
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Reference:
Patent; Beijing Yuan Bo Fang Pharmaceutical Technology Co., Ltd.; Li Jing; (26 pag.)CN104926797; (2019); B;,
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