Cobalt-catalyzed directed ortho-methylation of arenes with methyl tosylate was written by Sun, Qiao;Yoshikai, Naohiko. And the article was included in Organic Chemistry Frontiers in 2018.Quality Control of 2-(m-Tolyl)pyridine This article mentions the following:
A cobalt-catalyzed directed ortho C-H methylation reaction of arenes has been achieved using readily available Me tosylate as a methylating agent. An in situ-generated cobalt-N-heterocyclic carbene catalyst in combination with neopentyl magnesium bromide promotes the methylation at room temperature The reaction is applicable to various substrates bearing nitrogen directing groups such as N-aryl imine, N-H imine, and 2-pyridyl groups. The present protocol also allows for facile introduction of a trideuteriomethyl group into arenes. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Quality Control of 2-(m-Tolyl)pyridine).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Quality Control of 2-(m-Tolyl)pyridine