Tag: 100-200

A Boron Difluoride Hydrazone (BODIHY) Polymer Exhibits Aggregation-Induced Emission was written by Cappello, Daniela;Watson, Alexander E. R.;Gilroy, Joe B.. And the article was included in Macromolecular Rapid Communications in 2021.HPLC of Formula: 91-02-1 This article mentions the following:

Polymers that exhibit aggregation-induced emission (AIE) find use, for example, as cell-imaging agents and as fluorometric sensors due to their unique optical properties. However, the structural diversity of AIE-active polymers has not necessarily advanced at the same rate as their applications. In this work, ring-opening metathesis polymerization is used to synthesize the first example of a polymer (M_n = 61,600 g mol^-1, Dj = 1.32) containing boron difluoride hydrazone (BODIHY) heterocycles in its repeating unit. The BODIHY monomer and polymer described absorb and emit in the visible region in solution (λ_abs = 428 and 429 nm, λ_em = 528 and 526 nm) and as thin films (λ_abs = 443 and 440 nm, λ_em = 535 and 534 nm). Monomer (Φ_Film = 10%) and polymer (Φ_Film = 6%) exhibit enhanced emission as thin films compared to solution (Φ_Soln â‰?1%) as well as AIE upon the addition of water to DMF solutions as a result of restriction of intramol. motion. Enhancement factors for the monomer and polymer are determined to be 58 and 15, resp. The title BODIHY polymer exhibited an earlier onset of AIE and enhanced sensitivity to solution viscosity when compared to the parent monomer. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1HPLC of Formula: 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.HPLC of Formula: 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Base-Assisted Aerobic C-H Oxidation of Alkylarenes with a Murdochite-Type Oxide Mg₆MnO₈ Nanoparticle Catalyst was written by Hayashi, Eri;Tamura, Takatoshi;Aihara, Takeshi;Kamata, Keigo;Hara, Michikazu. And the article was included in ACS Applied Materials & Interfaces in 2022.COA of Formula: C12H9NO This article mentions the following:

Heterogeneously catalyzed aerobic oxidative C-H functionalization under mild conditions is a chem. process to obtain desired oxygenated products directly. Nanosized murdochite-type oxide Mg₆MnO₈ (Mg₆MnO₈-MA) was successfully synthesized by the sol-gel method using malic acid. The sp. surface area reached up to 104 m² g^-1, which is about 7 times higher than those (2-15 m² g^-1) of Mg₆MnO₈ synthesized by previously reported methods. Mg₆MnO₈-MA exhibited superior catalytic performance to those of other Mn- and Mg-based oxides, including manganese oxides with Mn-O-Mn active sites for the oxidation of fluorene with mol. oxygen (O₂) as the sole oxidant under mild conditions (40°C). The present catalytic system was applicable to the aerobic oxidation of various substrates. The catalyst could be recovered by simple filtration and reused several times without obvious loss of its high catalytic performance. The correlation between the reactivity and the pK_a of the substrates, basic properties of catalysts, and kinetic isotope effects suggest a basicity-controlled mechanism of hydrogen atom transfer. The ¹⁸O-labeling experiments, kinetics, and mechanistic studies showed that H abstraction of the hydrocarbon proceeds via a mechanism involving O₂ activation. The structure of Mg₆MnO₈ consisting of isolated Mn⁴⁺ species located in a basic MgO matrix plays an important role in the present oxidation In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1COA of Formula: C12H9NO).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.COA of Formula: C12H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Isomerization-Induced Multiple Reaction Pathways in Platinum-Catalyzed C-H Acylation Reaction of 2-Aryloxypyridines was written by Barham, Alexander;Neu, Justin;Canter, Cathleen L.;Pike, Robert D.;Li, Yumin;Huo, Shouquan. And the article was included in Organometallics in 2021.Quality Control of 2-Phenoxypyridine This article mentions the following:

In Pt-catalyzed C-H acylation of 2-(2-methylphenoxy)pyridine (L¹) with Et chlorooxoacetate to produce Et 2-(3-methyl-2-(pyridin-2-yloxy))phenyl-2-oxoacetate (L²), possible reaction steps involved in the catalytic cycle were studied, which include the ligand exchange of precatalysts cis- and trans-Pt(PhCN)₂Cl₂ with L¹, the intramol. C-H activation (cyclometalation) of cis- and trans-Pt(L¹)₂Cl₂ (1), and the acylation of the trans-cyclometalated Pt complex (trans-2) formed from the C-H activation reaction. The cis coordination compounds including the intermediate Pt complexes showed much higher reactivity toward the ligand exchange and the C-H activation than their trans isomers. Consequently, the cis isomers exhibit higher catalytic activity in the C-H acylation reaction. Although the C-H activation of cis- and trans-Pt(L¹)₂Cl₂ produces trans-2, the cis isomer (cis-2) is very likely formed in the C-H activation of cis-Pt(L¹)₂Cl₂ but undergoes isomerization to the more stable trans-2. Probably the fast reaction pathway via all cis-Pt complexes may be responsible for the efficient catalytic reaction, but isomerization of cis-2 to trans-2 could be highly competitive. The acylation of the trans-cycloplatinated complex produces both cis- and trans-Pt complexes Pt(L¹)(L²)Cl₂. The regaining of the cis-Pt complex revives the catalytic cycle. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Quality Control of 2-Phenoxypyridine).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of âˆ?8.7 × 10âˆ? cm3·molâˆ?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·molâˆ? in the liquid phase and 140.4 kJ·molâˆ? in the gas phase. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Quality Control of 2-Phenoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Aminomethylation Reaction of ortho-Pyridyl C-H Bonds Catalyzed by Group 3 Metal Triamido Complexes was written by Nagae, Haruki;Shibata, Yu;Tsurugi, Hayato;Mashima, Kazushi. And the article was included in Journal of the American Chemical Society in 2015.Reference of 644-98-4 This article mentions the following:

Tris[N,N-bis(trimethylsilyl)amido] complexes of group 3 metals, especially yttrium and gadolinium, served as catalysts for ortho-C-H bond addition of pyridine derivatives and N-heteroaromatics into the C=N double bond of nonactivated imines to afford the corresponding aminomethylated products. Addition of catalytic amounts of secondary amines, such as dibenzylamine, dramatically improved the catalytic activity through the formation of a mixed ligated complex such as [(Me₃Si)₂N]₂Y(NBn₂)(THF) (4). Furthermore, kinetic studies using the isolated complex 4 provided a plausible reaction mechanism by which coordination of two pyridine derivatives afforded a penta-coordinated species as a key step. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Reference of 644-98-4).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Reference of 644-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rhodium-Catalyzed Direct C-H Bond Cyanation in Ionic Liquids was written by Lv, Songyang;Li, Yaling;Yao, Tian;Yu, Xinling;Zhang, Chen;Hai, Li;Wu, Yong. And the article was included in Organic Letters in 2018.Synthetic Route of C12H11N This article mentions the following:

A Cp*Rh(III)/IL-based direct C-H bond cyanation system was developed for the first time. The system is a mild, efficient, and recyclable method for the synthesis of aryl nitriles. Many different directing groups can be used in this cyanation, and the reaction tolerates a variety of functional groups. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Synthetic Route of C12H11N).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Synthetic Route of C12H11N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Salen-based hypercrosslinked polymer-supported Pd as an efficient and recyclable catalyst for C-H halogenation was written by Meng, Di;Bi, Jiajun;Dong, Yahao;Hao, Bo;Qin, Kaiwei;Li, Tao;Zhu, Dajian. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Quality Control of 2-(m-Tolyl)pyridine This article mentions the following:

The first use of a salen-based hypercrosslinked polymer-supported Pd catalyst to carry out C-H halogenation was reported. This catalyst was effectively catalyze C-H bromination and chlorination even better than its homogeneous counterpart Pd(OAc)₂. It also showed excellent reusability without loss of catalytic activity for ten cycles. A broad substrate scope was explored and moderate to excellent yields were obtained. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Quality Control of 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Quality Control of 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Visible-Light-Induced Decarboxylative Acylation of Pyridine N-Oxides with α-Oxocarboxylic Acids Using Fluorescein Dimethylammonium as a Photocatalyst was written by Hou, Chuanfu;Sun, Shouneng;Liu, Ziqi;Zhang, Hui;Liu, Yue;An, Qi;Zhao, Jian;Ma, Junjie;Sun, Zhizhong;Chu, Wenyi. And the article was included in Advanced Synthesis & Catalysis in 2021.Category: pyridine-derivatives This article mentions the following:

The development of a visible-light-induced catalytic system achieved the decarboxylative acylation of pyridine N-oxides with α-oxocarboxylic acids, at room temperature and using the organic dye fluorescein dimethylammonium as a new type of photocatalyst was reported. A series of 2-arylacylpyridine N-oxides were selectively synthesized in moderate to good yields by controlling the polarity of the reaction solvent. The developed strategy was successfully applied in the synthesis of an important intermediate of the drug, acrivastine, on a gram scale. Notably, this is the first time that fluorescein dimethylammonium was used to catalyzed the Minisci-type C-H decarboxylative acylation reaction. The mechanism of decarboxylative acylation was studied by capturing adducts of acyl radicals and 1,1-diphenylethylene confirmed a radical mechanism. The disclosed catalytic system provided a green synthetic strategy for decarboxylative acylation without the use of addnl. oxidants or metal catalysts. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Category: pyridine-derivatives).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Incorporation of Hydrogen-Bonding Functionalities into the Second Coordination Sphere of Iron-Based Water-Oxidation Catalysts was written by Hoffert, Wesley A.;Mock, Michael T.;Appel, Aaron M.;Yang, Jenny Y.. And the article was included in European Journal of Inorganic Chemistry in 2013.Recommanded Product: 315180-16-6 This article mentions the following:

Energy storage and conversion schemes based on environmentally benign chem. fuels will require the discovery of faster, cheaper, and more robust catalysts for the oxygen-evolution reaction (OER). Although the incorporation of pendant bases into mol. catalysts for hydrogen production and use led to enhanced turnover frequencies, the analogous incorporation of pendant bases into mol. catalysts for water oxidation has received little attention. Herein, the syntheses, structures, and catalytic activities of new iron complexes with pendant bases are reported. Of these new complexes, [Fe(L¹)]²⁺ {L¹ = N,N’-dimethyl-N,N’-bis(pyridazin-3-ylmethyl)ethane-1,2-diamine} is the most active catalyst. Initial turnover frequencies of 141 and 24 h^-1 were measured by using ceric ammonium nitrate at pH 0.7 and sodium periodate at pH 4.7, resp. These results suggest that the incorporation of pendant bases into mol. catalysts for water oxidation might be an effective strategy that can be considered in the development of new catalysts for the OER, but will require the careful balance of many factors. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-6-fluoropyridine (cas: 315180-16-6Recommanded Product: 315180-16-6).

2-(Chloromethyl)-6-fluoropyridine (cas: 315180-16-6) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: 315180-16-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Stereospecific vicinal oxyamination of N-substituted 1,2,3,6-tetrahydropyridines and 1,2-dihydropyridines by N-chloro-N-metallocarbamates was written by Dubey, Sushil K.;Knaus, Edward E.. And the article was included in Canadian Journal of Chemistry in 1983.Recommanded Product: tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate This article mentions the following:

The vicinal oxyamination of 1-substituted 1,2,3,6-tetrahydropyridines (I; R = PhCO, PhSO₂, Me₃COCO, MeOCO, MeCO, PhCH₂) affords a mixture of the regioisomeric cis-hydroxycarbamates (II and III). The tert-butoxycarbonylamino and hydroxyl substituents for II and III assume the equatorial and axial orientations resp., irresp. of the substituent position. Acid hydrolysis of II– and III (R = PhCO) affords the cis-amino alcs. IV and V. The regiospecific oxyamination of 1-methyoxycarbonyl-1,2-dihydropyridine occurs at the 5,6-olefenic bond to yield the hydroxycarbamates VI and VII. Reduction of VI and VII with palladium on charcoal affords the same vicinal hydroxy and methoxycarbamates (VIII–XI) which may arise via an aziridine intermediate. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Recommanded Product: tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of âˆ?8.7 × 10âˆ? cm3·molâˆ?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·molâˆ? in the liquid phase and 140.4 kJ·molâˆ? in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Recommanded Product: tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Phosphodiesterase inhibitors. Part 3: Design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-dihydropyridazinones with anti-inflammatory and bronchodilatory activity was written by Ochiai, Koji;Takita, Satoshi;Eiraku, Tomohiko;Kojima, Akihiko;Iwase, Kazuhiko;Kishi, Tetsuya;Fukuchi, Kazunori;Yasue, Tokutaro;Adams, David R.;Allcock, Robert W.;Jiang, Zhong;Kohno, Yasushi. And the article was included in Bioorganic & Medicinal Chemistry in 2012.Category: pyridine-derivatives This article mentions the following:

(-)-6-(7-Methoxy-2-trifluoromethylpyrazolo[1,5-a]pyridin-4-yl)-5-methyl-4,5-dihydro-3-(2H)-pyridazinone (KCA-1490) is a dual PDE3/4 inhibitor that exhibits potent combined bronchodilatory and anti-inflammatory activity. A survey of potential bicyclic heteroaromatic replacement subunits for the pyrazolo[1,5-a]pyridine core of KCA-1490 has identified the 4-methoxy-2-(trifluoromethyl)benzo[d]thiazol-7-yl and 8-methoxy-2-(trifluoromethyl)quinolin-5-yl analogs as dual PDE3/4-inhibitory compounds that potently suppress histamine-induced bronchoconstriction and exhibit anti-inflammatory activity in vivo. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2Category: pyridine-derivatives).

3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem