Tag: 100-200

Reversible and Sensitive Hg²⁺ Detection by a Cell-Permeable Ytterbium Complex was written by Bao, Guochen;Zha, Shuai;Liu, Zhenyu;Fung, Yan-Ho;Chan, Chi-Fai;Li, Hongguang;Chu, Pak-Ho;Jin, Dayong;Tanner, Peter A.;Wong, Ka-Leung. And the article was included in Inorganic Chemistry in 2018.Product Details of 131747-45-0 This article mentions the following:

A cell-permeable ytterbium complex shows reversible binding with Hg²⁺ in aqueous solution and in vitro by off-on visible and NIR emission. The fast response and 150 nM sensitivity of Hg²⁺ detection is based upon FRET and the lanthanide antenna effect. The reversible Hg²⁺ detection can be performed in vitro, and the binding mechanism is suggested by NMR employing the motif structure in a La complex and by DFT calculations In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Product Details of 131747-45-0).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Product Details of 131747-45-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pd(II)-catalyzed o-aroylation of directing arenes using terminal aryl alkenes and alkynes was written by Khatun, Nilufa;Banerjee, Arghya;Santra, Sourav K.;Behera, Ahalya;Patel, Bhisma K.. And the article was included in RSC Advances in 2014.Recommanded Product: 2-Phenoxypyridine This article mentions the following:

A substrate-directed Pd-catalyzed o-aroylation strategy was demonstrated using new aroyl surrogates viz. terminal aryl alkenes and alkynes in the presence of TBHP. By a subtle change in catalyst from Cu to Pd, a differential selectivity was observed While terminal aryl alkenes/alkynes in the presence of Cu/TBHP were reported to act as o-aryloxy (ArCOO-) sources, the use of Pd/TBHP installed an aroyl (ArCO-) group at the ortho position with respect to the directing arenes. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Recommanded Product: 2-Phenoxypyridine).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Recommanded Product: 2-Phenoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kinetic analyses and structure-activity relationship studies of synthetic lysine acetylation catalysts was written by Yamatsugu, Kenzo;Furuta, Masahiro;Xi, Siqi;Amamoto, Yoshifumi;Liu, Jiaan;Kawashima, Shigehiro A.;Kanai, Motomu. And the article was included in Bioorganic & Medicinal Chemistry in 2018.HPLC of Formula: 131747-45-0 This article mentions the following:

Lysine acylation of proteins is a crucial chem. reaction, both as a post-translational modification and as a method for bioconjugation. We previously developed a chem. catalyst, DSH, which activates a chem. stable thioester including acyl-CoA, allowing the site-selective lysine acylation of histones under physiol. conditions. However, a more active catalyst is required for efficient lysine acylation in more complex biol. milieu, such as in living cells, but there are no rational guidelines for developing efficient lysine acylation catalysts for use under physiol. conditions as opposed to in organic solvents. We, herein, conducted a kinetic anal. of the ability of DSH and several derivatives to mediate lysine acetylation to better understand the structural elements essential for high acetylation activity under physiol. conditions. Interestingly, the obtained trend in reactivity was different from that observed in organic solvents, suggesting that a different principle is necessary for designing chem. catalysts specifically for use under physiol. conditions compared to catalysts for use in organic solvents. Based on the obtained information, we identified a new catalyst scaffold (PQSH) with high activity and structural flexibility for further modification to improve this catalyst system. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0HPLC of Formula: 131747-45-0).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.HPLC of Formula: 131747-45-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin was written by Metcalf, Brian;Chuang, Chihyuan;Dufu, Kobina;Patel, Mira P.;Silva-Garcia, Abel;Johnson, Carl;Lu, Qing;Partridge, James R.;Patskovska, Larysa;Patskovsky, Yury;Almo, Steven C.;Jacobson, Matthew P.;Hua, Lan;Xu, Qing;Gwaltney, Stephen L.;Yee, Calvin;Harris, Jason;Morgan, Bradley P.;James, Joyce;Xu, Donghong;Hutchaleelaha, Athiwat;Paulvannan, Kumar;Oksenberg, Donna;Li, Zhe. And the article was included in ACS Medicinal Chemistry Letters in 2017.Quality Control of 3,5-Dimethoxyisonicotinaldehyde This article mentions the following:

The authors report the discovery of a new potent allosteric effector of sickle cell Hb, GBT440 I, that increases the affinity of Hb for oxygen and consequently inhibits its polymerization when subjected to hypoxic conditions. Unlike earlier allosteric activators that bind covalently to Hb in a 2:1 stoichiometry, I binds with a 1:1 stoichiometry. Compound I is orally bioavailable and partitions highly and favorably into the red blood cell with a RBC/plasma ratio of �50. This partitioning onto the target protein is anticipated to allow therapeutic concentrations to be achieved in the red blood cell at low plasma concentrations I is in Phase 2 clin. trials for the treatment of sickle cell disease (NCT02285088). In the experiment, the researchers used many compounds, for example, 3,5-Dimethoxyisonicotinaldehyde (cas: 204862-70-4Quality Control of 3,5-Dimethoxyisonicotinaldehyde).

3,5-Dimethoxyisonicotinaldehyde (cas: 204862-70-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol� in pyridine vs. 150 kJ·mol� in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Quality Control of 3,5-Dimethoxyisonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cambiarenes: Single-Step Synthesis and Selective Zwitterion Binding of a Clip-Shaped Macrocycle with a Redox-Active Core was written by Petersen, Riley J.;Rozeboom, Brett J.;Oburn, Shalisa M.;Blythe, Nolan J.;Rathje, Tanner L.;Luna, Javier A.;Kibby, Steven K.;O’Brien, Emily A.;Rohr, Kayleigh G.;Carpenter, Joshua R.;Sanders, Taylor L.;Johnson, Andrew M.;Hutchins, Kristin M.;Shaw, Scott K.;MacGillivray, Leonard R.;Wackerly, Jay Wm.. And the article was included in Chemistry – A European Journal in 2020.Application In Synthesis of 2-Isopropylpyridine This article mentions the following:

A novel macrocyclic host mol. was synthesized that forms in a single step from com. available starting materials. The core of the macrocycle backbone possesses two quinone rings and, thus, it is redox-active. Host-guest binding involving the clip-shaped cavity indicates selective binding of pyridine N-oxides based on the electron d. of and steric bulk around the anionic oxygen. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Application In Synthesis of 2-Isopropylpyridine).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application In Synthesis of 2-Isopropylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Modification of the pyridine moiety of non-peptidyl indole GnRH receptor antagonists was written by Simeone, Joseph P.;Bugianesi, Robert L.;Ponpipom, Mitree M.;Yang, Yi Tien;Lo, Jane-Ling;Yudkovitz, Joel B.;Cui, Jisong;Mount, George R.;Ren, Rena Ning;Creighton, Mellissa;Mao, An-Hua;Vincent, Stella H.;Cheng, Kang;Goulet, Mark T.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2002.Category: pyridine-derivatives This article mentions the following:

The synthesis of a number of indole GnRH antagonists is described. Oxidation of the pyridine ring nitrogen, combined with alkylation at the two position, led to a compound with an excellent in vitro activity profile as well as oral bioavailability in both rats and dogs. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Category: pyridine-derivatives).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Catalytic C-H Bond Addition of Pyridines to Allenes by a Rare-Earth Catalyst was written by Song, Guoyong;Wang, Baoli;Nishiura, Masayoshi;Hou, Zhaomin. And the article was included in Chemistry – A European Journal in 2015.Quality Control of 2-Isopropylpyridine This article mentions the following:

The catalytic C-H addition of pyridines to allenes was achieved for the first time by using a half-sandwich scandium catalyst, thus constituted a straightforward and atom-economical route for the synthesis of alkenylated pyridines. The reaction proceeded regio- and stereoselectively, affording a new family of alkenylated pyridines which were otherwise difficult to synthesize. A cationic Sc-η²-pyridyl species was isolated and confirmed to be a key catalyst species in the transformation. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Quality Control of 2-Isopropylpyridine).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Quality Control of 2-Isopropylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Efficient synthesis of β-chlorovinylketones from acetylene in chloroaluminate ionic liquids was written by Snelders, Dennis J. M.;Dyson, Paul J.. And the article was included in Organic Letters in 2011.HPLC of Formula: 125652-55-3 This article mentions the following:

A method for the Friedel-Crafts-type insertion reaction of acetylene with acid chlorides in chloroaluminate ionic liquids is presented. The use of ionic liquids not only serves to avoid the use of carbon tetrachloride or 1,2-dichloroethane but also suppresses side reactions, notably the polymerization of acetylene, which occurs in these chlorinated solvents. Consequently, the products can be isolated using a simpler purification procedure, giving a range of aromatic and aliphatic β-chlorovinyl ketones in high yield and purity. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3HPLC of Formula: 125652-55-3).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.HPLC of Formula: 125652-55-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

N-O Bond as External Oxidant in Group 9 Cp*M(III)-Catalyzed Oxidative C-H Coupling Reactions was written by Liu, Xu-Ge;Gao, Hui;Zhang, Shang-Shi;Li, Qingjiang;Wang, Honggen. And the article was included in ACS Catalysis in 2017.Application of 4373-61-9 This article mentions the following:

O-Acylhydroxylamines and peresters were tried as external oxidants in rhodium-, iridium-, and cobalt-catalyzed oxidative coupling reactions; O-acylhydroxylamines such as RCOONEt₂ (R = Me, t-Bu) and 2,6-(MeO)₂C₆H₃COONR¹₂ (R¹ = Et, i-Pr) were found to be effective oxidants for oxidative coupling reactions of benzoic acids and benzophenone imines with alkynes and for oxidative Heck reactions of arylpyridines and 2-phenylpyrimidine with styrenes to give isocoumarines, isoquinolines, and pyridinyl- and pyrimidinylstilbenes. Using the Cp*Rh(III)-catalyzed isocoumarin synthesis as a model reaction, exptl. and theor. mechanistic studies were conducted to understand the mechanism of the oxidative coupling reactions using O-acylhydroxylamines as oxidants. A Rh(III)-Rh(I)-Rh(III) pathway is more likely involved in the oxidative coupling reactions than a Rh(III)-Rh(V)-Rh(III) pathway; both C-H activation and oxidation of the Cp*Rh(I) species were involved in the turnover-limiting step. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Application of 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application of 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Identification of a novel 2-pyridyl-benzensulfonamide derivative, RQ-00203078, as a selective and orally active TRPM8 antagonist was written by Ohmi, Masashi;Shishido, Yuji;Inoue, Tadashi;Ando, Kazuo;Fujiuchi, Akiyoshi;Yamada, Akiko;Watanabe, Shuzo;Kawamura, Kiyoshi. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.Recommanded Product: 3-Fluoro-5-(trifluoromethyl)pyridin-2-amine This article mentions the following:

A novel series of 2-pyridyl-benzensulfonamide derivatives have been identified as selective and orally active TRPM8 antagonists via high throughput screening (HTS). Exploration of the structure-activity relationships of compound (I) has led to the identification of RQ-00203078 (compound 36) as a highly selective, potent and orally available TRPM8 antagonist. RQ-00203078 demonstrated excellent in vivo activity in a dose dependent manner with an ED₅₀ value of 0.65 mg/kg in the icilin-induced wet-dog shakes model in rats after oral administration and may become an important pharmacol. tool for fully assessing the potential therapeutic use of the targets activated by cold stimulation. In the experiment, the researchers used many compounds, for example, 3-Fluoro-5-(trifluoromethyl)pyridin-2-amine (cas: 852062-17-0Recommanded Product: 3-Fluoro-5-(trifluoromethyl)pyridin-2-amine).

3-Fluoro-5-(trifluoromethyl)pyridin-2-amine (cas: 852062-17-0) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: 3-Fluoro-5-(trifluoromethyl)pyridin-2-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem