Tag: 100-200

One-Pot Preparation of 9,10-Dihydrophenanthrenes Initiated by Rhodium(III)-Catalyzed C-H Activation and Relay Diels-Alder Reaction was written by Gao, Dingding;Liu, Xing-Yu;Xu, Hao;Tan, Yun-Xuan;Liao, Qi;Li, Qing-Hua;Yang, Xiaodi;Lin, Guo-Qiang;Tian, Ping. And the article was included in Organic Letters in 2020.Recommanded Product: 2-(m-Tolyl)pyridine This article mentions the following:

An efficient one-pot synthesis of multisubstituted 9,10-dihydrophenanthrenes from easily available 2-arylazaarenes and cyclohexadienone-tethered terminal alkynes (1,6-enynes) has been successfully achieved. This domino reaction proceeded smoothly through Cp*Rh(III)-catalyzed C-H activation, direct protonation of alkenyl-Rh intermediates, intramol. Diels-Alder reaction, alkene isomerization, subsequent ring-opening aromatization, and acetylation. This strategy was pot-economical and tolerated a wide range of functional groups. Moreover, the potent anticancer activities against HepG2 cells were observed for these artificial 9,10-dihydrophenanthrene derivatives In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Recommanded Product: 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cobalt-Catalyzed C-H Acetoxylation of Phenols with Removable Monodentate Directing Groups: Access to Pyrocatechol Derivatives was written by Gou, Quan;Tan, Xiaoping;Zhang, Mingzhong;Ran, Man;Yuan, Tengrui;He, Shuhua;Zhou, Linzong;Cao, Tuanwu;Luo, Feihua. And the article was included in Organic Letters in 2020.Reference of 4783-68-0 This article mentions the following:

An efficient cobalt-catalyzed C-H acetoxylation of phenols ROR¹ (R = Ph, 4-chlorophenyl, naphthalen-1-yl, quinolin-6-yl, etc.; R¹ = pyridin-2-yl, 3-chloropyridin-2-yl, 3-methylpyridin-2-yl, pyrimidin-2-yl, 3-(2,4-difluorophenylaminocarbonyl)pyridin-2-yl) has been developed by using PIDA (phenyliodine diacetate) as a sole acetoxy source to synthesize pyrocatechol derivatives R²OR¹ (R² = 2-acetyloxyphenyl, 2-acetyloxy-4-chlorophenyl, 2-acetyloxynaphthalen-1-yl, 7-acetyloxyquinolin-6-yl, etc.) for the first time. The key feature of this method is the use of earth-abundant metal cobalt as the green and inexpensive catalyst for the acetoxylation of C(sp²)-H bonds under neutral reaction conditions. Furthermore, the gram-scale reaction and late-stage functionalization demonstrated the usefulness of this method. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Reference of 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of âˆ?8.7 × 10âˆ? cm3·molâˆ?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·molâˆ? in the liquid phase and 140.4 kJ·molâˆ? in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Reference of 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

V-Mg-O catalysts for oxidative dehydrogenation of alkylpyridines and alkylthiophenes was written by Belomestnykh, I. P.;Isaguliants, G. V.. And the article was included in Catalysis Today in 2009.Synthetic Route of C8H11N This article mentions the following:

Vanadium appears to be the element that is most frequent (along with molybdenum) used in the catalyst formulations for oxidative dehydrogenation (ODH) of hydrocarbons and alcs. The ODH reaction in the presence of air has been extended for the preparation of vinylpyridines and vinylthiophenes using vanadium (and for comparison molybdenum) oxide catalysts. The efficiency of vanadium-magnesium oxide catalysts in the production of vinylpyridines and vinylthiophenes has been evaluated. A strong dependence of the yield and selectivity of the latter upon the vanadium (molybdenum) oxide loading and the conditions of heat treatment were observed In optimized reaction conditions V-Mg-O catalysts at �450° ensured the formation of vinylpyridines and vinylthiophenes in 40-60% yield and 90% selectivity. In prolonged runs no visible changes in the performance of the catalyst were observed DTA-DTG, XRD, IR ESR, NMR methods have been used to detect the formation of species of V-Mg-O catalysts that appear to be responsible for the catalyst efficiency in the reactions under consideration. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Synthetic Route of C8H11N).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Synthetic Route of C8H11N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Microwave-promoted syntheses of pyridine carboxamides and tert-carboximides from novel 6-acetylpyridine-2-carboxylic acid was written by Su, Biyun;Zhao, Jianshe;Zhang, Qunzheng;Qin, Wenlong. And the article was included in Synthetic Communications in 2009.Recommanded Product: 122637-39-2 This article mentions the following:

A novel 6-acetylpyridine-2-carboxylic acid was obtained during the synthesis of Et 6-acetylpyridine-2-carboxylate from 2,6-dipicolinic acid. 6-Acetylpyridine-2-carboxylic acid reaction with one or two equivalent of aromatic amines under microwave irradiation resulting in pyridine carboxamides and pyridine carboximides, resp. In the experiment, the researchers used many compounds, for example, 6-Acetylpicolinic acid (cas: 122637-39-2Recommanded Product: 122637-39-2).

6-Acetylpicolinic acid (cas: 122637-39-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Recommanded Product: 122637-39-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The synthesis of piperidine nucleoside analogs-a comparison of several methods to access the introduction of nucleobases was written by Kovackova, Sona;Dracinsky, Martin;Rejman, Dominik. And the article was included in Tetrahedron in 2011.Formula: C10H17NO2 This article mentions the following:

This work deals with the synthesis of piperidine and hydroxypiperidine analogs of nucleosides, e.g. I. Starting from com. available 3-hydroxypiperidine, proline or 4-hydroxyproline, a series of piperidine derivatives of both purine and pyrimidine nucleobases was prepared Various methods of nucleobase attachment were evaluated. The prepared compounds were tested for cytostatic, antibacterial, and antiviral properties but no significant activity was found. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Formula: C10H17NO2).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Formula: C10H17NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase was written by De Schutter, Joris W.;Zaretsky, Serge;Welbourn, Sarah;Pause, Arnim;Tsantrizos, Youla S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Recommanded Product: 131747-45-0 This article mentions the following:

A structure-based approach was pursued in designing novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase (hFPPS). Preliminary SAR and structural evidence for the simultaneous binding of these inhibitors into the isopentenyl pyrophosphate (IPP) and the geranyl pyrophosphate (GPP) substrate sub-pockets of the enzyme are presented. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Recommanded Product: 131747-45-0).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: 131747-45-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Palladium-Catalyzed Site-Selective Amidation of Dichloroazines was written by Young, Ian S.;Glass, Anna-Lena;Cravillion, Theresa;Han, Chong;Zhang, Haiming;Gosselin, Francis. And the article was included in Organic Letters in 2018.Category: pyridine-derivatives This article mentions the following:

A highly site-selective amidation reaction of substituted 2,4-dichloroazines is reported. Palladium acetate/1,1′-bis(diphenylphosphino)ferrocene (dppf) was identified as the optimal catalyst system, producing >99:1 C-2/C-4 selectivity for most examples. The generality of this transformation was demonstrated through a survey of a diverse amide/substituted 2,4-dichloroazine scope, leading to the preparation of the desired C-2 amidated products in good to excellent yields. In the experiment, the researchers used many compounds, for example, 2,4-Dichloro-3-fluoropyridine (cas: 628691-85-0Category: pyridine-derivatives).

2,4-Dichloro-3-fluoropyridine (cas: 628691-85-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Desulfurization of fuel using ionic liquids: computational selection of cation and anion was written by Salleh, M. Zulhaziman M.;Wilfred, Cecilia D.;Abdul Mutalib, M. I.. And the article was included in Applied Mechanics and Materials in 2014.Recommanded Product: 125652-55-3 This article mentions the following:

Selection of potential ionic liquid (IL) is carried out in this work using COSMO-RS by analyzing the interaction between dibenzothiophene (DBT) and IL in dodecane. Sigma profile, capacity and selectivity at infinite dilution were used to predict the suitable ILs in desulfurization. Result shows that increasing alkyl length and incorporating nitrile group will increase the capacity and selectivity resp. 1-butyl-6-methylquinolonium [C₄mquin]⁺, 1-butyl-3- methylimidazolium [Bmim]⁺, thiocyanate [SCN]^– and dicyanamide [N(CN)₂]^– are potentially good cations and anions. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Recommanded Product: 125652-55-3).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of âˆ?8.7 × 10âˆ? cm3·molâˆ?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·molâˆ? in the liquid phase and 140.4 kJ·molâˆ? in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Recommanded Product: 125652-55-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Selective Isomerization via Transient Thermodynamic Control: Dynamic Epimerization of trans to cis Diols was written by Oswood, Christian J.;MacMillan, David W. C.. And the article was included in Journal of the American Chemical Society in 2022.Application of 85838-94-4 This article mentions the following:

Traditional approaches to stereoselective synthesis require high levels of enantio- and diastereocontrol in every step that forms a new stereocenter. Here, authors report an alternative approach, in which the stereochem. of organic substrates is selectively edited without further structural modification, a strategy with the potential to allow new classes of late-stage stereochem. manipulation and provide access to rare or valuable stereochem. configurations. In this work, authors describe a selective epimerization of cyclic diols enabled by hydrogen atom transfer photocatalysis and boronic acid mediated transient thermodn. control, selectively generating less stable cis products from the otherwise favored trans isomers. A range of substitution patterns and ring sizes are amenable to selective isomerization, including stereochem. complex polyols such as estriol, as well as syn to anti epimerization of acyclic vicinal diols. Moreover, this strategy has enabled the divergent epimerization of saccharide anomers, providing access to distinct sugar isomers from α- or β-configured glycosides. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Application of 85838-94-4).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of âˆ?8.7 × 10âˆ? cm3·molâˆ?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·molâˆ? in the liquid phase and 140.4 kJ·molâˆ? in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application of 85838-94-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and structure-activity relationship study of water-soluble carbazole sulfonamide derivatives as new anticancer agents was written by Liu, Yonghua;Wu, Yanbin;Sun, lianqi;Gu, Yuxi;Hu, Laixing. And the article was included in European Journal of Medicinal Chemistry in 2020.Reference of 28020-37-3 This article mentions the following:

Here, the structure-activity relationships of novel N-substituted carbazole sulfonamide derivatives I [R¹ = H, CH₂CH₂OH, 3-(1-piperidyl)propanoyl, etc.; R² = H, OH, OP(O)(ONa)₂] with improved physicochem. properties was formulated and investigated. Most of these new compounds displayed good aqueous solubility Certain mols. presented strong in vitro antiproliferative and in vivo antitumor activity. Relative to the control, 50 mg/kg compound I [R¹ = CH₂CH₂OP(O)(ONa)₂; R² = H] substantially reduced human HepG2 xenograft mouse tumor growth by 54.5% and its efficacy was comparable to that of CA-4P. Compound I [R¹ = 2-(4-methylpiperazin-1-yl)ethyl; R² = H] demonstrated anticancer efficacy in both s.c. and orthotopic HepG2 xenograft mouse models. A novel synthetic method for 7-hydroxy-substituted carbazole sulfonamides was also developed. Compared with the control, 25 mg/kg compound I [R¹ = H; R² = OP(O)(ONa)₂] inhibited human HepG2 xenograft mouse tumor growth by 71.7% and was more potent than 50 mg/kg CA-4P with only 50% tumor shrinkage efficacy. Among the three water-soluble carbazole sulfonamide derivatives formulated in the present study, compound I [R¹ = H; R² = OP(O)(ONa)₂] displayed the most effective tumor growth inhibition in vivo and merit further investigation as potential antitumor agents for cancer therapy. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Reference of 28020-37-3).

3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of âˆ?8.7 × 10âˆ? cm3·molâˆ?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·molâˆ? in the liquid phase and 140.4 kJ·molâˆ? in the gas phase. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Reference of 28020-37-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem