Tag: 100-200

Fife, Wilmer K. et al. published their research in Journal of Organic Chemistry in 1983 | CAS: 1620-76-4

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application of 1620-76-4

Regioselective cyanation of pyridine 1-oxides with trimethylsilanecarbonitrile: a modified Reissert-Henze reaction was written by Fife, Wilmer K.. And the article was included in Journal of Organic Chemistry in 1983.Application of 1620-76-4 This article mentions the following:

Pyridine 1-oxide and its 2- and 4-Me derivatives are converted in nearly quant. yield to the corresponding 2-pyridinecarbonitrile by treatment with equivalent amounts of Me3SiCN and Me2NCOCl in CH2Cl2. Similarly, 3-methylpyridine 1-oxide is converted to a mixture of 3-methyl-2-pyridinecarbonitrile (90%) and 5-methyl-2-pyridinecarbonitrile (5%). In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Application of 1620-76-4).

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application of 1620-76-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chang, Shang-Poa et al. published their research in Tetrahedron Letters in 2010 | CAS: 475057-86-4

4-Hydroxypicolinonitrile (cas: 475057-86-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of 4-Hydroxypicolinonitrile

Parallel synthesis enablement of 2-pyridyl-5-cyano-pyrimidine-6-ones-a novel class of HIF-hydroxylase inhibitors was written by Chang, Shang-Poa;Hungerford, William M.;McDonald, Wayne S.;Maguire, Robert J.;Malony, Kelly Q.;Subramanyam, Chakrapani. And the article was included in Tetrahedron Letters in 2010.Application In Synthesis of 4-Hydroxypicolinonitrile This article mentions the following:

The synthesis of various substituted 2-pyridyl-5-cyanopyrimidin-6-ones was accomplished via a three-step protocol. The key aspects of this parallel protocol were the preparation of amidines from nitriles under mild conditions followed by cyclization with Et (ethoxymethylene)cyanoacetate. In the experiment, the researchers used many compounds, for example, 4-Hydroxypicolinonitrile (cas: 475057-86-4Application In Synthesis of 4-Hydroxypicolinonitrile).

4-Hydroxypicolinonitrile (cas: 475057-86-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of 4-Hydroxypicolinonitrile

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ghatak, Avishek et al. published their research in Tetrahedron Letters in 2014 | CAS: 4783-68-0

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application of 4783-68-0

Chemoselective and ligand-free synthesis of diaryl ethers in aqueous medium using recyclable alumina-supported nickel nanoparticles was written by Ghatak, Avishek;Khan, Sagar;Roy, Rimi;Bhar, Sanjay. And the article was included in Tetrahedron Letters in 2014.Application of 4783-68-0 This article mentions the following:

An economical and eco-compatible ligand-free protocol for the synthesis of diaryl ethers R1OR2 (R1 = Ph, 2-pyridyl, 3-pyridyl, etc.; R2 = Ph, 2-MeC6H4, 4-ClC6H4, 2-naphthyl, etc.) from the corresponding aryl halides R1X (X = Cl, Br, I) and phenols R2OH has been developed using easily accessible alumina-supported nickel nanoparticles as a stable recyclable heterogeneous catalyst in aqueous medium along with a surfactant (SDS) and a mild base (K2CO3). Various sensitive functional groups like allyl, alkoxycarbonyl, formyl, oxo, chloro, bromo, amine and nitro were tolerated in this method. Excellent chemoselectivity was demonstrated through competition experiments In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Application of 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application of 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Jianmin et al. published their research in Journal of Medicinal Chemistry in 2007 | CAS: 15128-90-2

3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Name: 3-Hydroxy-6-methyl-2-nitropyridine

Design, synthesis, and evaluation of inhibitors for severe acute respiratory syndrome 3C-Like protease based on phthalhydrazide ketones or heteroaromatic esters was written by Zhang, Jianmin;Pettersson, Hanna I.;Huitema, Carly;Niu, Chunying;Yin, Jiang;James, Michael N. G.;Eltis, Lindsay D.;Vederas, John C.. And the article was included in Journal of Medicinal Chemistry in 2007.Name: 3-Hydroxy-6-methyl-2-nitropyridine This article mentions the following:

The 3C-like protease (3CLpro), which controls the severe acute respiratory syndrome (SARS) coronavirus replication, has been identified as a potential target for drug design in the treatment of SARS. A series of tetrapeptide phthalhydrazide ketones, pyridinyl esters, and their analogs have been designed, synthesized, and evaluated as potential SARS 3CLpro inhibitors. Some pyridinyl esters, e.g., I, were identified as very potent inhibitors, with IC50 values in the nanomolar range (50-65 nM). Electrospray mass spectrometry indicated a mechanism involving acylation of the active site cysteine thiol for this class of inhibitors. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2Name: 3-Hydroxy-6-methyl-2-nitropyridine).

3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Name: 3-Hydroxy-6-methyl-2-nitropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pascanu, Vlad et al. published their research in Chemistry – A European Journal in 2016 | CAS: 4373-61-9

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Synthetic Route of C12H11N

Selective Heterogeneous C-H Activation/Halogenation Reactions Catalyzed by Pd@MOF Nanocomposites was written by Pascanu, Vlad;Carson, Fabian;Solano, Marta Vico;Su, Jie;Zou, Xiaodong;Johansson, Magnus J.;Martin-Matute, Belen. And the article was included in Chemistry – A European Journal in 2016.Synthetic Route of C12H11N This article mentions the following:

A directed heterogeneous C-H activation/halogenation reaction catalyzed by readily synthesized Pd@MOF nanocatalysts was developed. The heterogeneous Pd catalysts used were a novel and environmentally benign Fe-based metal-organic framework (MOF) [Pd@MIL-88B-NH2(Fe)] and the previously developed Pd@MIL-101-NH2(Cr). Very high conversions and selectivities were achieved under very mild reaction conditions and in short reaction times. A wide variety of directing groups, halogen sources, and substitution patterns were well tolerated, and valuable polyhalogenated compounds were synthesized in a controlled manner. The synthesis of the Pd-functionalized Fe-based MOF and the recyclability of the two catalysts are also presented. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Synthetic Route of C12H11N).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Synthetic Route of C12H11N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jiao, Lin-Yu et al. published their research in Catalysis Communications in 2021 | CAS: 4783-68-0

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 4783-68-0

Rhodium(III)-catalyzed chelation-assisted ortho-selective carbon-hydrogen alkylation of phenols with diazocarbonyl compounds involving a carbene migratory insertion process was written by Jiao, Lin-Yu;Ning, Zi-Hui;Yin, Xiao-Mei;Hong, Qian;Liu, Shanshan;Ma, Xiao-Xun. And the article was included in Catalysis Communications in 2021.Recommanded Product: 4783-68-0 This article mentions the following:

An efficient and convenient rhodium(III)-catalyzed chelation-assisted ortho-selective carbon-hydrogen bond alkylation of phenols treated with readily available diazocarbonyl compounds as the alkyl source has been described. Migratory carbene insertion represents the principal step to realize this carbenoid coupling transformation, giving rise to a broad rang of alkylated products and at the same time, releasing nitrogen gas as sole byproduct. This protocol offers exclusive regioselectivities, moderate to excellent chem. yields, and good functional group tolerance. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Recommanded Product: 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Barre, Baptiste et al. published their research in Organic Letters in 2014 | CAS: 85838-94-4

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate

Iron- and Cobalt-Catalyzed Arylation of Azetidines, Pyrrolidines, and Piperidines with Grignard Reagents was written by Barre, Baptiste;Gonnard, Laurine;Campagne, Remy;Reymond, Sebastien;Marin, Julien;Ciapetti, Paola;Brellier, Marie;Guerinot, Amandine;Cossy, Janine. And the article was included in Organic Letters in 2014.Recommanded Product: tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate This article mentions the following:

Iron- and cobalt-catalyzed cross-couplings between iodo-azetidines, -pyrrolidines, -piperidines, and Grignard reagents are disclosed. The reaction is efficient, cheap, chemoselective and tolerates a large variety of (hetero)aryl Grignard reagents. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Recommanded Product: tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Veyseh, Somayeh et al. published their research in Journal of the Chilean Chemical Society in 2015 | CAS: 628-13-7

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Name: Pyridinehydrochloride

Application of multivariate image analysis in QSPR study of pKa of various acids by principal components-least squares support vector machine was written by Veyseh, Somayeh;Hamzehali, Hamideh;Niazi, Ali;Ghasemi, Jahan B.. And the article was included in Journal of the Chilean Chemical Society in 2015.Name: Pyridinehydrochloride This article mentions the following:

A new implemented quant. structure-property relationships (QSPR) method, whose descriptors achieved from bidimensional images, was suggested for the predicting of acidity constant (pKa) of various acid. The resulted descriptors were subjected to principal component anal. (PCA) and the most significant principal components (PCs) were extracted Multivariate image anal. applied to QSPR modeling was done by means of principal component-least squares support vector machine (PC-LSSVM) methods. The resulted model showed high prediction ability with root mean square error of prediction of 0.0195 for PC-LSSVM. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Name: Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Name: Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hummel, Michael et al. published their research in Green Chemistry in 2011 | CAS: 125652-55-3

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Computed Properties of C10H16ClN

Dimethyl phosphorothioate and phosphoroselenoate ionic liquids as solvent media for cellulosic materials was written by Hummel, Michael;Froschauer, Carmen;Laus, Gerhard;Roeder, Thomas;Kopacka, Holger;Hauru, Lauri K. J.;Weber, Hedda K.;Sixta, Herbert;Schottenberger, Herwig. And the article was included in Green Chemistry in 2011.Computed Properties of C10H16ClN This article mentions the following:

A series of novel ionic liquids comprising two asym. phosphate-derived anions, namely di-Me phosphorothioate and di-Me phosphoroselenoate, and several imidazolium and non-imidazolium-based cations was prepared via a facile synthetic route. Thermal degradation was studied by dynamic thermogravimetric anal. (TGA) revealing a slightly higher stability of the imidazolium ionic liquids and an overall low thermal stability for the phosphoroselenoate salts. Long-term moisture sorption anal. showed correlation with the polarity of the cation and differences in absorption and desorption kinetics. Finally, a Eucalyptus globulus kraft paper grade pulp was dissolved and subsequently regenerated to assess the degradation of the various mol. weight fractions by size exclusion chromatog. In addition, pre-extracted xylan was subjected to the same dissolution procedure to examine the degradation of low-mol. weight components in more detail. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Computed Properties of C10H16ClN).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Computed Properties of C10H16ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Song, Lianjun et al. published their research in Separation and Purification Technology in 2021 | CAS: 122637-39-2

6-Acetylpicolinic acid (cas: 122637-39-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: 6-Acetylpicolinic acid

2-Carboxamido-6-(1H-pyrazol-3-yl)-pyridines as ligands for efficient separation of americium(III) from europium(III) was written by Song, Lianjun;Wang, Xueyu;Wang, Dongqi;Xiao, Qian;Xu, Haowei;Li, Qiuju;He, Lanlan;Ding, Songdong. And the article was included in Separation and Purification Technology in 2021.Recommanded Product: 6-Acetylpicolinic acid This article mentions the following:

The synthesis, Eu3+ complexation, and selective solvent extraction of Am3+ over Eu3+ in nitric acid solution by 2-carboxamido-6-(1H-pyrazol-3-yl)-pyridines (A-PzPy) ligands were described. Without the aid of any lipophilic anion source, A-PzPy ligands in Me iso-Bu ketone (MIBK) diluent demonstrated a more favorable affinity of Am3+ than Eu3+ at high acidity levels. Slope anal. showed the formation of 1:2 metal/ligand extracted species. The extraction was a spontaneous exothermic process. The analyses of fluorescence titration, Fourier transform IR (FT-IR), Raman, time-resolved laser fluorescence spectrum (TRLFS), electrospray ionization mass spectrometry (ESI-MS), conductivity and microcalorimetric titration revealed that the composition of complex is [Eu(NO3)2(H2O)•2(Et-p-Tol-A-PzPy)](NO3). Combining the results of solvent extraction and complexation study, the extraction mechanism was proposed. stability constants (log β) and thermodn. parameters (ΔH, ΔS, ΔG) for complexation of Eu3+ with Et-p-Tol-A-PzPy are presented. In the experiment, the researchers used many compounds, for example, 6-Acetylpicolinic acid (cas: 122637-39-2Recommanded Product: 6-Acetylpicolinic acid).

6-Acetylpicolinic acid (cas: 122637-39-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: 6-Acetylpicolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem