Tag: 100-200

Aqueous biphasic systems composed of ionic liquids and sodium carbonate as enhanced routes for the extraction of tetracycline was written by Marques, Carlos F. C.;Mourao, Teresa;Neves, Catarina M. S. S.;Lima, Alvaro S.;Boal-Palheiros, Isabel;Coutinho, Joao A. P.;Freire, Mara G.. And the article was included in Biotechnology Progress in 2013.Safety of 1-Butyl-3-methylpyridinium Chloride This article mentions the following:

Aqueous biphasic systems (ABS) using ionic liquids (ILs) offer an alternative approach for the extraction, recovery, and purification of biomols. through their partitioning between two aqueous liquid phases. In this work, the ability of a wide range of ILs to form ABS with aqueous solutions of Na₂CO₃ was evaluated. The ABS formed by IL + water + Na₂CO₃ were determined at 25°C, and the resp. solubility curves, tie-lines, and tie-line lengths are reported. The studied ILs share the common chloride anion, allowing the IL cation core, the cation isomerism, the presence of functionalized groups, and alkyl side chain length effects to be evaluated. An increase in the cation side alkyl chain length leads to a higher ability for liquid-liquid demixing whereas different positional isomers and the presence of an allyl group have no major influence in the phase diagrams behavior. Quaternary phosphonium- and ammonium-based fluids are more able to form an ABS when compared with imidazolium-, pyridinium-, pyrrolidinium-, and piperidium-based ILs. Moreover, the presence of an aromatic cation core has no major contribution to the formation of ABS when compared to the resp. nonaromatic counterparts. Finally, to appraise on the systems applicability in downstream processing, selected systems were used for the partitioning of tetracyclines (neutral and salt forms) – a class of antibiotics produced by bacteria fermentation Single-step extraction efficiencies for the IL-rich phase were always higher than 99% and confirm the great potential of ILs to be applied in the biotechnol. field. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Safety of 1-Butyl-3-methylpyridinium Chloride).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Safety of 1-Butyl-3-methylpyridinium Chloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Binding affinity of pyridines with Am^III/Cm^III elucidated by density functional theory calculations was written by Yu, Jie;Ma, Jun;Yang, Chuting;Yu, Haizhu. And the article was included in Dalton Transactions in 2019.Related Products of 644-98-4 This article mentions the following:

In recent decades, N-heterocyclic ligands have been extensively used in the separation of lanthanides/actinides, whereas the selective extraction of amercium or curium has been very challenging. Using d. functional theory calculations, this study is devoted to the investigation of the binding affinity of a series of modeling pyridine ligands with AmIII and CmIII. The structure-property correlations between the amercium and curium systems and the binding affinity were obtained, and promising strategies for efficient separation of AmIII/CmIII were proposed. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Related Products of 644-98-4).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Related Products of 644-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lewis acid-catalyzed regioselective C-H carboxamidation of indolizines with dioxazolones via an acyl nitrene type rearrangement was written by Song, Dan;Huang, Changfeng;Liang, Peishi;Zhu, Baofu;Liu, Xiang;Cao, Hua. And the article was included in Organic Chemistry Frontiers in 2021.Product Details of 24103-75-1 This article mentions the following:

An efficient, direct, and novel Lewis acid-catalyzed regioselective C-H carboxamidation of indolizines with dioxazolones via an acyl nitrene type rearrangement under metal-free conditions was documented. A diverse array of indolizine-3-carboxamides I [R = Ph, 4-MeC₆H₄, 2-naphthyl, etc.; R¹ = H, 8-Me, 6-Et, etc.; R² = Ph, 4-MeC₆H₄, 2-FC₆H₄, etc.] were achieved in moderate to good yields with wide substrate scope. In these transformations, isocyanatobenzene was formed by the ring opening of dioxazolones and a subsequent Curtius-type rearrangement, which could be harnessed in C-H carboxamidation of N-heterocycles. The present protocol is satisfactorily complementary to nitrene transfer chem. and C-H functionalization of N-heterocycles. Furthermore, photophys. experiments revealed that a few compounds exhibited high fluorescence absorption and emission intensity. In the experiment, the researchers used many compounds, for example, 4-Methoxy-2-methylpyridine (cas: 24103-75-1Product Details of 24103-75-1).

4-Methoxy-2-methylpyridine (cas: 24103-75-1) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Product Details of 24103-75-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The Hemetsberger-Knittel synthesis of substituted 5-, 6-, and 7-azaindoles was written by Roy, Patrick J.;Dufresne, Claude;Lachance, Nicolas;Leclerc, Jean-Philippe;Boisvert, Michel;Wang, Zhaoyin;Leblanc, Yves. And the article was included in Synthesis in 2005.Category: pyridine-derivatives This article mentions the following:

A series of substituted 5-, 6-, and 7-azaindoles were prepared via the Hemetsberger-Knittel reaction. In general, better yields were obtained at higher temperatures and shorter reaction times than required for the formation of the analogous indoles, and in some cases, only decomposition occurred below a min. temperature The resulting templates offer up to five sites for subsequent functionalization to allow a wide range of chem. diversity. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)nicotinaldehyde (cas: 116308-35-1Category: pyridine-derivatives).

2-(Trifluoromethyl)nicotinaldehyde (cas: 116308-35-1) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Palladium-Catalyzed Direct C(sp²)-H Alkoxylation of 2-Aryloxypyridines Using 2-Pyridyloxyl as the Directing Group was written by Zhang, Chun;Sun, Peipei. And the article was included in Journal of Organic Chemistry in 2014.SDS of cas: 4783-68-0 This article mentions the following:

An efficient and highly regioselective palladium-catalyzed ortho-C(sp²)-H bond alkoxylation of 2-aryloxypyridines was developed using 2-pyridyloxyl as the directing group and alcs. as alkoxylation reagents. Under an air atm. and in the presence of PhI(OAc)₂, the reaction gave the corresponding products in moderate to good yields, and a series of functional groups could be tolerated. E.g., in the presence of Pd(OAc)₂ and PhI(OAc)₂, regioselective alkoxylation of 2-aryloxypyridine derivative (I) with MeOH gave 58% II. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0SDS of cas: 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.SDS of cas: 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Side reactions during preparation and handling of oligomers and polymers from 2-vinylpyridine was written by Schmitz, F. P.;Hilgers, H.;Gemmel, B.. And the article was included in Makromolekulare Chemie in 1990.SDS of cas: 644-98-4 This article mentions the following:

Side reactions occurring during the polymerization and oligomerization of vinylpyridine were discussed, and some of them evidenced by experiments The occurrence of ring substitution at the pyridine ring was demonstrated by model reactions. In addition, chain rearrangement in solution was observed From the exptl. results conclusions are drawn for the choice of the appropriate conditions for preparation and handling of polymers and oligomers of vinylpyridine. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4SDS of cas: 644-98-4).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. SDS of cas: 644-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

High-performance organic light-emitting diodes with low-efficiency roll-off using bulky tetradentate [Pt(ON̂ĈN̂)] emitters was written by Mao, Mao;Peng, Jiahuan;Lam, Tsz-Lung;Ang, Wai-Hung;Li, Huiyang;Cheng, Gang;Che, Chi-Ming. And the article was included in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2019.Recommanded Product: 628-13-7 This article mentions the following:

High-performance organic light-emitting diodes (OLEDs) were realized by utilizing three robust platinum(II) complexes bearing tetradentate ON̂ĈN̂ ligands with a bridging tertiary amine (tetra-Pt-N), a biphenyl group with a spiro linkage (tetra-Pt-S) or a sterically encumbered 2,6-dimethyl-4-tert-butylphenyl moiety (tetra-Pt-M). By using a double-host emissive layer (EML) structure and a 10 nm-thick interlayer between the EML and the electron-transport layer (ETL), a maximum power efficiency of over 100 lm W^-1, a low turn-on voltage of less than 2.5 V and low efficiency roll-off were achieved. A high external quantum efficiency (EQE) of 19.4% and 20.3% was maintained at 10 000 cd m^-2 in OLEDs with tetra-Pt-N and tetra-Pt-M, resp. Such high efficiency at high luminance could be attributed to the effective suppression of triplet-triplet annihilation (TTA) in our optimized device structure. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Recommanded Product: 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Decarboxylative Borylation and Cross-Coupling of (Hetero)aryl Acids Enabled by Copper Charge Transfer Catalysis was written by Dow, Nathan W.;Pedersen, P. Scott;Chen, Tiffany Q.;Blakemore, David C.;Dechert-Schmitt, Anne-Marie;Knauber, Thomas;MacMillan, David W. C.. And the article was included in Journal of the American Chemical Society in 2022.Recommanded Product: 2-Chloro-5-fluoropyridin-3-ol This article mentions the following:

Authors report a copper-catalyzed strategy for arylboronic ester synthesis that exploits photoinduced ligand-to-metal charge transfer (LMCT) to convert (hetero)aryl acids into aryl radicals amenable to ambient-temperature borylation. This near-UV process occurs under mild conditions, requires no prefunctionalization of the native acid, and operates broadly across diverse aryl, heteroaryl, and pharmaceutical substrates. They also report a one-pot procedure for decarboxylative cross-coupling that merges catalytic LMCT borylation and palladium-catalyzed Suzuki-Miyaura arylation, vinylation, or alkylation with organo bromides to access a range of value-added products. The utility of these protocols is highlighted through the development of a heteroselective double-decarboxylative C(sp²)-C(sp²) coupling sequence, pairing copper-catalyzed LMCT borylation and halogenation processes of two distinct acids (including pharmaceutical substrates) with subsequent Suzuki-Miyaura cross-coupling. In the experiment, the researchers used many compounds, for example, 2-Chloro-5-fluoropyridin-3-ol (cas: 884494-35-3Recommanded Product: 2-Chloro-5-fluoropyridin-3-ol).

2-Chloro-5-fluoropyridin-3-ol (cas: 884494-35-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: 2-Chloro-5-fluoropyridin-3-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ir(III)-catalyzed C-H alkynylation of arenes under chelation assistance was written by Tang, Guo-Dong;Pan, Cheng-Ling;Xie, Fang. And the article was included in Organic & Biomolecular Chemistry in 2016.SDS of cas: 4783-68-0 This article mentions the following:

An efficient and mild Ir(III)-catalyzed, chelation assisted C-H alkynation of arenes, e.g., I has been developed using hypervalent iodine alkynes II (R = t-Bu, TIPS, TES, TBDPS) as alkynylating reagents. A broad scope of N-phenyl-2-aminopyridines and 2-phenoxypyridines has been established as effective substrates for this C-H functionalization and the desired alkynylated products, e.g., III are isolated in moderate to high yields. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0SDS of cas: 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.SDS of cas: 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nucleophilic aromatic substitution reactions under aqueous, mild conditions using polymeric additive HPMC was written by Borlinghaus, Niginia;Ansari, Tharique N.;Braje, Leon H.;Ogulu, Deborah;Handa, Sachin;Wittmann, Valentin;Braje, Wilfried M.. And the article was included in Green Chemistry in 2021.Electric Literature of C6H3FN2 This article mentions the following:

The use of the inexpensive, benign, and sustainable polymer, hydroxypropyl methylcellulose (HPMC), in water enabled nucleophilic aromatic substitution (S_NAr) reactions between various nucleophiles and electrophiles. The mild reaction conditions facilitated a broad functional group tolerance that was utilized for subsequent derivatization for the synthesis of pharmaceutically relevant building blocks. The use of only equimolar amounts of all reagents and water as reaction solvent revealed the greenness and sustainability of the methodol. presented herein. In the experiment, the researchers used many compounds, for example, 6-Fluoronicotinonitrile (cas: 3939-12-6Electric Literature of C6H3FN2).

6-Fluoronicotinonitrile (cas: 3939-12-6) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Electric Literature of C6H3FN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem