Tag: 100-200

Novel carbazole sulfonamide derivatives of antitumor agent: Synthesis, antiproliferative activity and aqueous solubility was written by Sun, Lianqi;Wu, Yanbin;Liu, Yonghua;Chen, Xiaofang;Hu, Laixing. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Formula: C7H10N2O2 This article mentions the following:

The current optimization of IG-105 on the carbazole-ring provided a series of new carbazole sulfonamides derivatives All of the compounds have been evaluated against HepG2 cells (hepatoma cancer) for antiproliferative activity. Compounds that showed activity better or comparable to that of IG-105 vs. HepG2 were evaluated against MCF-7 (breast cancer), MIA PaCa-2 (pancreatic cancer), and Bel-7402 (hepatoma/liver cancer) for antiproliferative activity. Of the seven compounds selected for further study five were found to give IC₅₀ values against the four cell lines comparable to those for IG-105. Two compounds (I and II) were more active than IG-105 and their activity against HepG2 and MCF-7 (IC₅₀:0.01-0.07 μM) approached that of the pos. controls podophyllotoxin (podo) and CA-4. Most of compounds showed aqueous solubility (0.11-19.60 μg/mL at pH 7.4 and 2.0) better than IG-105. These promising results warrant further development of new compounds I and II as potential potent antitumor drug candidates. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Formula: C7H10N2O2).

3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Formula: C7H10N2O2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Studies on phenylcyclopropanecarboxylates. 3. A convenient method for the preparation of 6-phenoxy-2-pyridinecarboxaldehyde was written by Ozawa, Kiyomi;Ishii, Shigeru;Hatanaka, Masataka. And the article was included in Chemistry Letters in 1985.Name: 2-Phenoxypyridine This article mentions the following:

Title aldehyde I (R = CHO) (II) was prepared in 62.4-93.6% yields from halides I (R = Br, Cl) via a Grignard reaction. Thus, the direct reaction of I (R = Br) with Mg in the presence or absence of EtBr or MeI in THF gave the corresponding Grignard reagent, which was treated with DMF to give II. II was obtained in 85.7% yield in the absence of EtBr or MeI, whereas the yields of II increased in the presence of EtBr. Grignard reactions had not been regarded as a good method for the synthesis of pyridinecarbaldehydes. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Name: 2-Phenoxypyridine).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Name: 2-Phenoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Alternatives to Iridium: A Polyaza[7]helicene as a Strongly Reductive Visible Light Photoredox Catalyst was written by Rocker, Johannes;Opatz, Till. And the article was included in ACS Organic & Inorganic Au in 2022.Electric Literature of C7H6N2 This article mentions the following:

The use of a readily accessible polyazahelicene as a strongly reducing metal-free alternative to the commonly used precious metal based photo redox catalysts is demonstrated. An improved two-step synthesis of the catalyst is described, and its photophys. properties with respect to its use as a photo redox catalyst are evaluated. Its activity under visible light irradiation is proven by application in two double radical light-driven multi-component reactions. The azahelicene gave comparable results to an iridium-based catalyst originally used for the same transformations. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Electric Literature of C7H6N2).

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Electric Literature of C7H6N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and herbicidal activity of 2-cyano-3-methylthio-3-(substituted methylamino)acrylates was written by Gao, Ying;Zou, Xiao-Mao;Yu, Li-Min;Xu, Han;Liu, Bin;Zhu, You-Quan;Hu, Fang-Zhong;Yang, Hua-Zheng. And the article was included in Chinese Journal of Chemistry in 2006.Recommanded Product: 6-Fluoronicotinonitrile This article mentions the following:

A series of 3-amino-2-cyano-3-(methylthio)acrylates were synthesized as herbicidal inhibitors of photosystem II electron transport, in order to estimate the effect of fluorine atom, pyridyl group, chirality, and ester chain on activity. The important intermediate 2-fluoro-5-(aminomethyl)pyridine was synthesized with high yield. The bioassay results showed that most of title compounds had high herbicidal activity in postemergence treatment. The introduction of an α-Me into the 3-substituted methylamino could improve the activity notably. The replacement of H by Cl or F group and Ph by pyridyl group showed different effects, and at the same time, the ester chain affected the activity too. In the experiment, the researchers used many compounds, for example, 6-Fluoronicotinonitrile (cas: 3939-12-6Recommanded Product: 6-Fluoronicotinonitrile).

6-Fluoronicotinonitrile (cas: 3939-12-6) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: 6-Fluoronicotinonitrile

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyrazolopyridines. Part 5. Preparation and reactions of pyrazolo[3,4-c]pyridines was written by Chapman, David;Hurst, Jim. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1980.Safety of 2-Methoxy-4-methylpyridin-3-amine This article mentions the following:

Pyrazolopyridines I (R = H, R¹ = Me, OMe, Cl; R = OMe, Cl, R¹ = H) were prepared in good yield by nitrosation of the corresponding pyridines II, followed by rearrangement, cyclization and hydrolysis. The ring system readily underwent electrophilic substitution in the 3-position; I (R = Cl, R¹ = H) was more susceptible to nucleophilic substitution than its isomer I (R = H, R¹ = Cl). The 1- and 2-Ac and -Bz derivatives of I were prepared and their structures determined from spectral data. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-methylpyridin-3-amine (cas: 76005-99-7Safety of 2-Methoxy-4-methylpyridin-3-amine).

2-Methoxy-4-methylpyridin-3-amine (cas: 76005-99-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Safety of 2-Methoxy-4-methylpyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem