Tag: 100-200

O-Perfluoropyridin-4-yl Oximes: Iminyl Radical Precursors for Photo- or Thermal-Induced N-O Cleavage in C(sp²)-C(sp³) Bond Formation was written by Xia, Peng-Ju;Hu, Yuan-Zhuo;Ye, Zhi-Peng;Li, Xu-Jie;Xiang, Hao-Yue;Yang, Hua. And the article was included in Journal of Organic Chemistry in 2020.Application of 700-16-3 The following contents are mentioned in the article:

O-Perfluoropyridin-4-yl group was first installed onto cycloketone oximes as a new electrophore, which was proven to be efficient iminyl radical precursors under photocatalytic and thermal conditions. A range of O-perfluoropyridin-4-yl oximes were successfully utilized in C(sp²)-C(sp³) bond formations of quinoxalin-2(1H)-ones and alkenes, providing facile accesses to a range of functionalized alkylnitriles. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Application of 700-16-3).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application of 700-16-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Polyfluoroarylation of oxazolones: Access to non-natural fluorinated amino acids was written by Teegardin, Kip A.;Weaver, Jimmie D.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Electric Literature of C5F5N The following contents are mentioned in the article:

Herein, conditions are provided for the formation and use of the oxazolone enolate for the nucleophilic substitution of highly fluorinated (hetero)arenes, which after unmasking yield highly fluorinated non-natural amino acids and derivatives In addition, the properties and chem. behavior of this new class of amino acids are explored. The utility is demonstrated in the one pot synthesis of medicinally relevant 2-aminohydantoins. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Electric Literature of C5F5N).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Electric Literature of C5F5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Decarboxylative Polyfluoroarylation of Alkylcarboxylic Acids was written by Sun, Xiang;Ritter, Tobias. And the article was included in Angewandte Chemie, International Edition in 2021.Computed Properties of C5F5N The following contents are mentioned in the article:

Polyfluoroarenes are useful building blocks in several areas such as drug discovery, materials, and crop protection. Herein, we report the first polyfluoroarylation of aliphatic carboxylic acids via photoredox decarboxylation. The method proceeds with broad substrate scope and high functional group tolerance. Moreover, small complex mols. such as natural products and drugs can be modified by late-stage modification. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Computed Properties of C5F5N).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Computed Properties of C5F5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

C-F bond activation by pentamethylcyclopentadienyl-aluminum(I): a combined experimental/computational exercise was written by Kysliak, Oleksandr;Goerls, Helmar;Kretschmer, Robert. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Product Details of 700-16-3 The following contents are mentioned in the article:

The reaction of (Cp*Al)₄ with a series of fluoro(hetero)arenes has been investigated and C-F bond activation was observed with perfluorotoluene, pentafluoropyridine as well as 1,2,3,4-tetrafluoro-, pentafluoro- and hexafluorobenzene. The reaction mechanism has been probed by means of DFT calculations and the computational findings are in good agreement with the exptl. observations. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Product Details of 700-16-3).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Product Details of 700-16-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

UV photoelectron spectroscopy studies of the diazaxylylenes generated from amino(hydroxymethyl)pyridines was written by Chrostowska, A.;Sotiropoulos, J.-M.;Pfister-Guillouzo, G.;Wojciechowski, K.. And the article was included in Polish Journal of Chemistry in 2003.Recommanded Product: (3-Aminopyridin-2-yl)methanol The following contents are mentioned in the article:

Diazaxylylenes generated by 1,4-elimination of water from amino(hydroxymethyl)pyridines under flash vacuum thermolysis (FVT) conditions can be directly studied by the UV-photoelectron spectroscopy (UV-PES). The elimination of water from these compounds starts at 450° and is completed at 500-550°. The interpretation of UV-photoelectron spectra was supported by D. Functional Theory studies. This study involved multiple reactions and reactants, such as (3-Aminopyridin-2-yl)methanol (cas: 52378-63-9Recommanded Product: (3-Aminopyridin-2-yl)methanol).

(3-Aminopyridin-2-yl)methanol (cas: 52378-63-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: (3-Aminopyridin-2-yl)methanol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of some fluorinated thiazolopyridine from pentafluoropyridine and 4-phenylsulfonyl tetrafluoropyridine was written by Ranjbar-Karimi, Reza;Danesteh, Roghayeh;Beiki-Shoraki, Khalil. And the article was included in Arabian Journal of Chemistry in 2019.Computed Properties of C5F5N The following contents are mentioned in the article:

The reaction of pentafluoropyridine and 4-phenylsulfonyl-2,3,5,6-tetrafluoropyridine with difunctional nitrogen and sulfur nucleophiles such as thiourea, thioamide derivatives, and unsym. bidentate nitrogen nucleophiles such as diamino-triazole and amino-imidazole in the presence of sodium carbonate was investigated in this paper. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Computed Properties of C5F5N).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Computed Properties of C5F5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of some benzo[b][1,8] and [1,5]naphthyridines was written by Chen, Qingping;Deady, Leslie W.. And the article was included in Journal of Heterocyclic Chemistry in 1992.Formula: C6H8N2O The following contents are mentioned in the article:

A series of carboxylic acid derivatives of the title compounds, e.g. I and II, were prepared as precursors of potential anti-tumor compounds, by annulation of 2-methylcyclohexanone to the appropriate aminopyridinecarboxaldehyde followed by aromatization and oxidation of the Me group. This study involved multiple reactions and reactants, such as (3-Aminopyridin-2-yl)methanol (cas: 52378-63-9Formula: C6H8N2O).

(3-Aminopyridin-2-yl)methanol (cas: 52378-63-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Formula: C6H8N2O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cobalt(I)-catalyzed cocyclotrimerization of acetylene with 2,6-dicyanopyridines was written by Chelucci, Giorgio;Cabras, M. Antonietta;Saba, A.. And the article was included in Journal of Heterocyclic Chemistry in 1994.Reference of 159727-87-4 The following contents are mentioned in the article:

A procedure of general application to the synthesis of alkyl-substituted 2-cyano-6-(2-pyridyl)pyridines from alkylpyridines is outlined. Thus, [CpCo(COD)] (Cp = cyclopentadienyl, COD = 1,5-cyclooctadiene) catalyzed cocyclotrimerization of acetylene with 2,6-dicyanopyridine gave 70% 6-cyano-2,2′-bipyridine. This study involved multiple reactions and reactants, such as 2-Cyano-5-methylpyridine 1-oxide (cas: 159727-87-4Reference of 159727-87-4).

2-Cyano-5-methylpyridine 1-oxide (cas: 159727-87-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Reference of 159727-87-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Facile Synthesis of 3-Arylindenes by HMPA-Promoted Direct Arylation of Indenes with Aryl Fluorides was written by Ji, Xinfei;Li, Jialu;Wu, Mingsheng;Cao, Song. And the article was included in ACS Omega in 2018.Recommanded Product: 700-16-3 The following contents are mentioned in the article:

A rapid and efficient approach to 3-arylated indenes I (R¹ = H, Et, Br, Ph; R² = H, 4-Me, 3-Me, 3-OMe, etc.) by reactions of indenes with unactivated fluoroarenes with the assistance of LDA and HMPA at room temperature was developed. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Recommanded Product: 700-16-3).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Recommanded Product: 700-16-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

S_NAr catalysis enhanced by an aromatic donor-acceptor interaction; facile access to chlorinated polyfluoroarenes was written by Senaweera, Sameera;Weaver, Jimmie D.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Reference of 700-16-3 The following contents are mentioned in the article:

Selective catalytic S_NAr reaction of polyfluoroaryl C-F bonds with chloride is shown. Stoichiometric TMSCl makes the reaction exergonic and allows catalysis, which involves ground state elevation of chloride, aromatic donor-acceptor interactions, and stabilization of the Meisenheimer complex. Traditional cross-coupling of the products is now possible and demonstrates the utility. Thus, e.g., treatment of pentafluoropyridine with TMSCl and benzyltributylammonium chloride afforded 4-chloro-2,3,5,6-tetrafluoropyridine (95%). This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Reference of 700-16-3).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of �8.7 �10� cm3路mol�.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ路mol� in the liquid phase and 140.4 kJ路mol� in the gas phase. Pyridine derivatives are also useful as small-molecule �helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Reference of 700-16-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem