Tag: 100-200

Synthesis of fluorinated nitrogen heterocycles as new drug scaffolds was written by Hasoubah, Amani Hasan. And the article was included in Journal of Basic and Environmental Sciences in 2021.Related Products of 700-16-3 The following contents are mentioned in the article:

The amine compound (N-(2-bromophenyl)-4-methyl-N-(perfluoropyridin-4-yl)benzenesulfonamide) was successfully synthesized which was needed to find a strategy to synthesize fluorinated nitrogen heterocycles. The aim of this study was to made a cyclized product by treating the amine compound with different reagents to effect metalation in the bromophenyl group which could result in SNAr reaction in the fluorinated ring. However, treating the target compound with Bu-Li or Mg interestingly gave two different compounds which had lost the sulfonyl group. In addition, the reaction of (N-(2-bromophenyl)-4-methyl-N-(perfluoropyridin-4-yl)benzenesulfonamide) with Cu and 2- bromophenyltetrafluoropyridinamine with Cu was unsuccessful due to the recovery of the starting material as a major product and a minor percentage of new compounds had formed. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Related Products of 700-16-3).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule 伪-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Related Products of 700-16-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fluoromaticity: The Molecular Orbital Contributions of Fluorine Substituents to the 蟺-Systems of Aromatic Rings was written by Fuhrer, Timothy J.;Houck, Matthew;Iacono, Scott T.. And the article was included in ACS Omega in 2021.Safety of 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:

The addition of fluorine atoms to an aromatic ring brings about an addnl. set of 蟺-bonding and antibonding orbitals culminating after the addition of the sixth fluorine with a new set of 蟺-aromatic-like orbitals that affect the mol. in a way that we will refer to hereafter as “fluoromaticity”. Depending on the number and position of the fluorine atoms, the contributed 蟺-orbitals can even further stabilize the ring leading to smaller bond lengths within the ring and higher resistance to addition reactions. This added ring stability partially explains the high thermostability and chem. resistance found in polymers containing fluorinated aromatics in their architecture. A similar MO effect is seen with the addition of other halogen atoms to aromatic rings, though to a much smaller degree and not resulting in the addnl. ring stability. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Safety of 2,3,4,5,6-Perfluoropyridine).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Safety of 2,3,4,5,6-Perfluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ge(0) Compound Stabilized by a Diimino-Carbene Ligand: Synthesis and Ambiphilic Reactivity was written by Nguyen, Minh Tho;Gusev, Dmitry;Dmitrienko, Anton;Gabidullin, Bulat M.;Spasyuk, Denis;Pilkington, Melanie;Nikonov, Georgii I.. And the article was included in Journal of the American Chemical Society in 2020.Formula: C5F5N The following contents are mentioned in the article:

The germylone dimNHCGe (5, dimNHC = diimino N-heterocyclic carbene) was successfully prepared via the reduction of the germanium cation [dimNHCGeCl]⁺ with KC₈. The mol. structure of 5 was unambiguously established by both NMR spectroscopy and single-crystal X-ray diffraction. The reactivity of 5 was investigated, revealing that it undergoes oxidative addition of HCl, CH₃I, and PhI, accompanied by an unusual migration of the H, Me, and Ph groups from germanium to the carbene ligand. Related chem. was also observed with C₅F₅N, which results in the migration of the fluorinated pyridine moiety to the carbene ligand. Compound 5 also undergoes cycloaddition with tetrachloro-o-benzoquinone to afford a Ge(IV) adduct. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Formula: C5F5N).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six 蟺 electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H眉ckel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C鈥揌 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Formula: C5F5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Developing Comprehensive Computational Parameter Sets To Describe the Performance of Pyridine-Oxazoline and Related Ligands was written by Guo, Jing-Yao;Minko, Yury;Santiago, Celine B.;Sigman, Matthew S.. And the article was included in ACS Catalysis in 2017.Category: pyridine-derivatives The following contents are mentioned in the article:

The applicability of computational descriptors extracted from metal pyridine-oxazoline complexes to relate both site and enantioselectivity to structural diversity was investigated. A group of computationally derived features (e.g., metal NBO charges, steric descriptors, torsion angles) were acquired for a library of pyridine-oxazoline ligands. Correlation studies were employed to examine steric/electronic features described by each descriptor, followed by application of the said descriptors in modeling the results of two reaction types, the site-selective redox-relay Heck reaction and the enantioselective Carroll rearrangement, affording simple, well-validated models. Through exptl. validation and extrapolation, parameters derived from ground state metal complexes were found to be advantageous over those from the free ligand. This study involved multiple reactions and reactants, such as 4-Chloro-2-(4,5-dihydro-1,3-oxazol-2-yl)pyridine (cas: 1423027-73-9Category: pyridine-derivatives).

4-Chloro-2-(4,5-dihydro-1,3-oxazol-2-yl)pyridine (cas: 1423027-73-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A Study of Kamlet-Taft 尾 and 蟺* Scales of Solvent Basicity and Polarity/Polarizability Using Computationally Derived Molecular Properties was written by Waghorne, W. Earle. And the article was included in Journal of Solution Chemistry in 2020.Safety of 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:

The Kamlet and Taft solvent basicity parameter, 尾, and solvent polarity/polarizability parameter, 蟺*, were analyzed in terms of properties of the solvent mols. derived from computational chem. The anal. of 尾, using a larger data set, confirms earlier conclusions that, for aprotic solvents, the basicity is determined by the partial charge on the most neg. atom of the solvent mol. and by the energy of the highest energy MO associated with the donor site. For alcs. and nitrogen bases containing N-H moieties, the 尾 values deviate systematically from those for the non-hydrogen bonding solvents. Anal. of the polarity/polarizability parameter, 蟺*, shows that it depends directly on the dipole moment, and quadrupolar amplitude of the solvent and on the energy of the HOMO, but decreases linearly with increasing solvent polarizability. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Safety of 2,3,4,5,6-Perfluoropyridine).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 鈭?8.7 脳 10鈭? cm3路mol鈭?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ路mol鈭? in the liquid phase and 140.4 kJ路mol鈭? in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C鈥揌 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Safety of 2,3,4,5,6-Perfluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formation of non-natural 伪,伪-disubstituted amino esters via catalytic Michael addition was written by Teegardin, Kip A.;Gotcher, Lacey;Weaver, Jimmie D.. And the article was included in Organic Letters in 2018.COA of Formula: C5F5N The following contents are mentioned in the article:

The enolate monoanion of amino esters is explored, and the first catalytic Michael addition of 伪-amino esters is demonstrated. These studies indicate that the acidity of the 伪C-H is the primary factor determining reactivity. Thus, polyfluorophenylglycine amino esters yield novel 伪-amino esters in the presence of a catalytic amount of a guanidine-derived base and Michael acceptors. Reactivity requires an acidic N-H, which is accomplished using common protecting groups such as N-Bz, N-Boc, and N-Cbz. Calculations and labeling experiments provide insight into the governing principles in which a key C-to-N proton transfer occurs, resulting in an expansion of the scope to include a number of natural amino esters. The study culminates with a late-stage functionalization of peptidic 纬-secretase inhibitor, DAPT. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3COA of Formula: C5F5N).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six 蟺 electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H眉ckel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. COA of Formula: C5F5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Twisted Push-Pull Alkenes Bearing Geminal Cyclicdiamino and Difluoroaryl Substituents was written by Kundu, Abhinanda;Chandra, Shubhadeep;Mandal, Debdeep;Neuman, Nicolas I.;Mahata, Alok;Anga, Srinivas;Rawat, Hemant;Pal, Sudip;Schulzke, Carola;Sarkar, Biprajit;Chandrasekhar, Vadapalli;Jana, Anukul. And the article was included in Journal of Organic Chemistry in 2021.Computed Properties of C5F5N The following contents are mentioned in the article:

The systematic combination of N-heterocyclic olefins (NHOs) with fluoroarenes resulted in twisted push-pull alkenes. These alkenes carry electron-donating cyclicdiamino substituents and two electron-withdrawing fluoroaryl substituents in the geminal positions. The synthetic method can be extended to a variety of substituted push-pull alkenes by varying the NHO as well as the fluoroarenes. Solid-state mol. structures of these mols. reveal a notable elongation of the central C-C bond and a twisted geometry in the alkene motif. Absorption properties were investigated with UV-vis spectroscopy. The redox properties of the twisted push-pull alkenes were probed with electrochem. as well as UV-vis/NIR and EPR spectroelectrochem., while the electronic structures were computationally evaluated and validated. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Computed Properties of C5F5N).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ路mol鈭? in pyridine vs. 150 kJ路mol鈭? in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C鈥揌 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Computed Properties of C5F5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ni-catalyzed regio- and stereo-defined intermolecular cross-electrophile dialkylation of alkynes without directing group was written by Zhan, Yi-Zhou;Xiao, Nan;Shu, Wei. And the article was included in Nature Communications in 2021.Reference of 700-16-3 The following contents are mentioned in the article:

The nickel-catalyzed intermol. cross-dialkylation of alkynes devoid of directing or activating groups afforded multiple aliphatic substituted alkenes in a syn-selective fashion at room temp was reported. The combination of two-electron oxidative cyclometallation and single-electron cross-electrophile coupling of nickel enabled the syn-cross-dialkylation of alkynes at room temperature This reductive protocol enabled the sequential installation of two different alkyl substituents onto alkynes in a regio- and stereo-selective manner, circumvented the tedious preformation of sensitive organometallic reagents. The synthetic utility of this protocol was demonstrated by efficient synthesis of multi-substituted unfunctionalized alkenes and diverse transformations of the product. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Reference of 700-16-3).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Reference of 700-16-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Protecting Group-Controlled Remote Regioselective Electrophilic Aromatic Halogenation Reactions was written by Brittain, William D. G.;Cobb, Steven L.. And the article was included in Journal of Organic Chemistry in 2020.Product Details of 700-16-3 The following contents are mentioned in the article:

Being able to utilize a protecting group to influence remote regiocontrol offers a simple alternative approach to direct late-stage functionalization of complex organic mols. However, protecting groups that have the ability to influence reaction regioselectivity remote to their local chem. environment are not widely reported in the literature. Herein, we report the development of remote regioselective electrophilic aromatic substitution (S_EAr) reactions that are enabled via the application of the tetrafluoropyridyl (TFP) phenol-protecting group. We demonstrate that through sequential reactions and protection/deprotection of the TFP group, substitution patterns that do not conform to classical S_EAr regioselectivity rules can be readily accessed. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Product Details of 700-16-3).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six 蟺 electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H眉ckel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C鈥揌 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Product Details of 700-16-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Photoredox-Controlled Mono- and Di-Multifluoroarylation of C(sp³)-H Bonds with Aryl Fluorides was written by Xie, Jin;Rudolph, Matthias;Rominger, Frank;Hashmi, A. Stephen K.. And the article was included in Angewandte Chemie, International Edition in 2017.Synthetic Route of C5F5N The following contents are mentioned in the article:

A controllable mono- and di-multifluoroarylation of acyclic and cyclic N-aryl amines with aryl fluorides by photocatalyzed dual C(sp³)-H/C(sp²)-F functionalization has been developed, providing new access to a wide array of valuable 伪-fluoroarylated amines. In addition, the one-pot consecutive hetero-di-multifluoroarylation of N-aryl pyrrolidines and N,N-dimethylanilines was achieved with high to excellent diastereoselectivity. This new defluorinative C(sp³)-C(sp²) coupling is distinguished by a broad scope, good regioselectivity, and mild conditions as well as gram-scale and late-stage applicability, and thus constitutes a significant advance in the arylation of unactivated C(sp³)-H bonds with aryl fluorides. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Synthetic Route of C5F5N).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Synthetic Route of C5F5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem