Tag: 100-200

MOF-Derived Nanocobalt for Oxidative Functionalization of Cyclic Amines to Quinazolinones with 2-Aminoarylmethanols was written by Xie, Feng;Chen, Qing-Hua;Xie, Rong;Jiang, Huan-Feng;Zhang, Min. And the article was included in ACS Catalysis in 2018.Computed Properties of C6H8N2O The following contents are mentioned in the article:

By employing a MOF-templated method, we have developed a highly dispersed and ultralow loading cobalt nanocatalyst, which has been applied in the oxidative functionalization of easily available cyclic amines with 2-aminoarylmethanols to ring-fused quinazolinones, the core structures of numerous valuable products. The developed catalytic transformation proceeds with the merits of broad substrate scope, good functional group tolerance and chemoselectivity, high step- and atom-efficiency, and use of the naturally abundant Co/O₂ system, which offers a practical way for the preparation of quinazolinones with structural diversity. The work presented has built an important basis for direct conversion of cyclic amine motifs into functional frameworks. This study involved multiple reactions and reactants, such as (3-Aminopyridin-2-yl)methanol (cas: 52378-63-9Computed Properties of C6H8N2O).

(3-Aminopyridin-2-yl)methanol (cas: 52378-63-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six 蟺 electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H眉ckel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Computed Properties of C6H8N2O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Transition-Metal-Free Coupling of Polyfluorinated Arenes and Functionalized, Masked Aryl Nucleophiles was written by Finck, Lucie;Oestreich, Martin. And the article was included in Chemistry – A European Journal in 2021.Application In Synthesis of 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:

A chemoselective C(sp²)-C(sp²) coupling of sufficiently electron-deficient fluorinated arenes and functionalized N-aryl-N’-silyldiazenes as masked aryl nucleophiles is reported. The fluoride-promoted transformation involves the in situ generation of the aryl nucleophile decorated with various sensitive functional groups followed by a stepwise nucleophilic aromatic substitution (S_NAr). These reactions typically proceed at room temperature within minutes. This catalytic process allows for the functionalization of both coupling partners, furnishing highly fluorinated biaryls in good yields. Thus, e.g., diazene I + hexafluorobenzene 鈫?II (92%, 79% isolated) in presence of CsF in DMF. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Application In Synthesis of 2,3,4,5,6-Perfluoropyridine).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application In Synthesis of 2,3,4,5,6-Perfluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Survey reactivity of 5-substituted tetrazoles toward pentafluoropyridine was written by Ranjbar-Karimi, Reza;Poorfreidoni, Alireza. And the article was included in Journal of Fluorine Chemistry in 2019.Synthetic Route of C5F5N The following contents are mentioned in the article:

Reactivity of some 5-substituted tetrazoles with pentafluoropyridine under basic conditions in acetonitrile was investigated. The reaction of pentafluoropyridine with tetrazoles regioselectively occurred at the 4-position of pyridine ring by N2 in the tetrazole ring. Tetrazoles with Ph, 4-O₂NC₆H₄, 4-CF₃CONHC₆H₄, 4-ClC₆H₄CH₂, EtO₂CCH₂ or 5-tetrazolyl-CH₂ substituent at the position 5 gave the products I (R as listed above) containing unchanged tetrazole moiety. In contrast, tetrazole with substituents 3-(5-tetrazolyl)C₆H₄, 4-MeOC₆H₄ or 3-CF₃CONHC₆H₄ at the position 5 gave hydrazide products, e.g., II (R = 4-MeOC₆H₄, 3-CF₃CONHC₆H₄), via degradation of the tetrazole ring. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Synthetic Route of C5F5N).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Synthetic Route of C5F5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Selective and Scalable Perfluoroarylation of Nitroalkanes was written by Day, Jon I.;Weaver, Jimmie D.. And the article was included in Journal of Organic Chemistry in 2017.Synthetic Route of C5F5N The following contents are mentioned in the article:

Functionalized per- and polyfluoroarenes are important building blocks, with many industrially and medicinally important mols. containing them. Nucleophilic aromatic substitution can be employed as a quick and straightforward way to synthesize these building blocks. While many methods to derivatize fluoroarenes exist that use heteroatom centered nucleophiles, there are fewer methods that use carbon centered nucleophiles, and of those many are poorly defined. This work presents the SNAr reaction of nucleophiles generated from nitroalkanes with a variety of fluorinated arenes. Given that the products are versatile, accessing polyfluorinated arene building blocks in substantial scale is important. This method is highly regioselective, and produces good to moderate yields on a large scale, sans chromatog., and thus fulfills this need. In addition, the regioselectivity of the addition was probed using both DFT calculations and exptl. via halogen exchange. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Synthetic Route of C5F5N).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Synthetic Route of C5F5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Strategic Approach on N-Oxides in Gold Catalysis – A Case Study was written by Schiessl, Jasmin;Stein, Philipp M.;Stirn, Judith;Emler, Kirsten;Rudolph, Matthias;Rominger, Frank;Hashmi, A. Stephen K.. And the article was included in Advanced Synthesis & Catalysis in 2019.Application In Synthesis of 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:

An extensive kinetic study of selected key reactions of (oxidative) gold catalysis concentrates on the decrease of the catalytic activity due to inhibition of the gold(I) catalyst caused by pyridine derivatives that were obtained as byproducts if N-oxides are applied as oxygen donors. The choice of the examined pyridine derivatives and their corresponding N-oxides has been made regardless of their com. availability; particular attention has been paid to the practical benefit which up to now has been neglected in most of the reaction screenings. The test reactions were monitored by GC and ¹H NMR spectroscopy. The received reaction constants provide information concerning a correlation between the electronic structure of the heterocycle and the catalytic activity. Based on the collected kinetic data, it was possible to develop a basic set of three N-oxides which have to be taken into account in further oxidative gold(I)-catalyzed reactions. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Application In Synthesis of 2,3,4,5,6-Perfluoropyridine).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ路mol鈭? in pyridine vs. 150 kJ路mol鈭? in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application In Synthesis of 2,3,4,5,6-Perfluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of 2-hydroxy-5-(2′,3′,5′,6′-tetrafluoropyridylazo)benzaldehyde and 2-hydroxy-5-(2′,3′,5′,6′-tetrafluoro-pyridylazo)phenyl N-sulphanilamide-1-imine was written by Choula, Samira;Sekhri, Lakhdar;Hadjadj, Sadek. And the article was included in Heterocyclic Letters in 2020.Safety of 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:

The present work aimed mainly to synthesize new fluorinated azo-compounds and Schiff base. Thus pentafluoropyridine was aminated to the compound 4-amino-2,3,5,6-tetrafluoropyridine and then diazotized to the corresponding diazonium compound The resulting diazonium ions coupled, in-situ, to salicylaldehyde giving the corresponding azo-compounds, i.e., 2-hydroxy-5-(2′,3′,5′,6′-tetrafluoropyridylazo)benzaldehyde and 2-hydroxy-3-(2′,3′,5′,6′-tetrafluoropyridylazo)benzaldehyde as red crystals in 85% yield. The purity of these azo-compounds were estimated by TLC technique while their structures were established by the usual spectroscopic methods such as A UV, IR, MS and ¹H NMR. Fluorinated azo-compound coupled readily to salicylaldehyde resulting a new fluorinated base Schiff, 2-hydroxy-5-(2′,3′,5′,6′-tetrafluoro-pyridylazo)phenyl N-sulfanilamide-1-imine in 40% yield. The purity of this product was established by its IR, NMR and mass spectra. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Safety of 2,3,4,5,6-Perfluoropyridine).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six 蟺 electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H眉ckel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Safety of 2,3,4,5,6-Perfluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Catalytic Hydrodefluorination via Oxidative Addition, Ligand Metathesis, and Reductive Elimination at Bi(I)/Bi(III) Centers was written by Pang, Yue;Leutzsch, Markus;Noethling, Nils;Katzenburg, Felix;Cornella, Josep. And the article was included in Journal of the American Chemical Society in 2021.Related Products of 700-16-3 The following contents are mentioned in the article:

Herein, authors report a hydrodefluorination reaction of polyfluoroarenes catalyzed by bismuthinidenes, Phebox-Bi(I) and OMe-Phebox-Bi(I). Mechanistic studies on the elementary steps support a Bi(I)/Bi(III) redox cycle that comprises C(sp²)-F oxidative addition, F/H ligand metathesis, and C(sp²)-H reductive elimination. Isolation and characterization of a cationic Phebox-Bi(III)(4-tetrafluoropyridyl) triflate manifests the feasible oxidative addition of Phebox-Bi(I) into the C(sp²)-F bond. Spectroscopic evidence was provided for the formation of a transient Phebox-Bi(III)(4-tetrafluoropyridyl) hydride during catalysis, which decomposes at low temperature to afford the corresponding C(sp²)-H bond while regenerating the propagating Phebox-Bi(I). This protocol represents a distinct catalytic example where a main-group center performs three elementary organometallic steps in a low-valent redox manifold. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Related Products of 700-16-3).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Related Products of 700-16-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Round-Trip Oxidative Addition, Ligand Metathesis, and Reductive Elimination in a P^III/P^V Synthetic Cycle was written by Lim, Soohyun;Radosevich, Alexander T.. And the article was included in Journal of the American Chemical Society in 2020.Related Products of 700-16-3 The following contents are mentioned in the article:

A synthetic cycle for aryl C-F substitution comprising oxidative addition, ligand metathesis, and reductive elimination at a C_s-sym. phosphorus triamide PN(2-MeNC₆H₄)₂ (1) is reported. Reaction of 1 with perfluoroarenes (Ar^F-F) results in C-F oxidative addition, yielding fluorophosphoranes 1路[F][Ar^F]. The P-fluoro substituent is exchanged for hydride by treatment with DIBAL-H, generating hydridophosphoranes 1路[H][Ar^F]. Heating of 1路[H][Ar^F] regenerates 1 by C-H reductive elimination of Ar^F-H, where exptl. and computational studies establish a concerted but highly asynchronous mechanism. The results provide well-characterized examples of the full triad of elementary mechanistic aryl C-X substitution steps at a single main-group site. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Related Products of 700-16-3).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six 蟺 electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H眉ckel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C鈥揌 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Related Products of 700-16-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and antidiabetic activity of 2,5-disubstituted-3-imidazol-2-yl-pyrrolo[2,3-b]pyridines and thieno[2,3-b]pyridines was written by Bahekar, Rajesh H.;Jain, Mukul R.;Jadav, Pradip A.;Prajapati, Vijay M.;Patel, Dipam N.;Gupta, Arun A.;Sharma, Ajay;Tom, Robby;Bandyopadhya, Debdutta;Modi, Honey;Patel, Pankaj R.. And the article was included in Bioorganic & Medicinal Chemistry in 2007.Quality Control of 5-Chloro-2-methyl-1H-pyrrolo[2,3-b]pyridine The following contents are mentioned in the article:

In the present investigation, two series of 2,5-disubstituted-3-imidazol-2-yl-pyrrolo[2,3-b]pyridines (2a-l) and thieno[2,3-b]pyridines (3a-l) were designed as analogs of BL 11282 (1). The in vitro glucose dependent insulinotropic activity of all the test compounds was evaluated using RIN5F cell based assay and all the test compounds showed glucose and concentration dependent insulin secretion. The in vivo antidiabetic activities of most potent compounds from each series (I and II) were assessed in C57BL/6J mice. Compounds I and II showed dose dependent insulin secretion and significant glucose reduction in vivo. In general, compounds I and II were found to be equipotent at all the three different doses selected and with respect to BL 11282, both the test compounds were found to be more potent, at all the time points. This study involved multiple reactions and reactants, such as 5-Chloro-2-methyl-1H-pyrrolo[2,3-b]pyridine (cas: 145934-81-2Quality Control of 5-Chloro-2-methyl-1H-pyrrolo[2,3-b]pyridine).

5-Chloro-2-methyl-1H-pyrrolo[2,3-b]pyridine (cas: 145934-81-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 鈭?8.7 脳 10鈭? cm3路mol鈭?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ路mol鈭? in the liquid phase and 140.4 kJ路mol鈭? in the gas phase. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Quality Control of 5-Chloro-2-methyl-1H-pyrrolo[2,3-b]pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Transition-Metal-Free Catalytic Hydrodefluorination of Polyfluoroarenes by Concerted Nucleophilic Aromatic Substitution with a Hydrosilicate was written by Kikushima, Kotaro;Grellier, Mary;Ohashi, Masato;Ogoshi, Sensuke. And the article was included in Angewandte Chemie, International Edition in 2017.Computed Properties of C5F5N The following contents are mentioned in the article:

Polyfluorinated arenes underwent regioselective transition metal-free hydrodefluorination with Ph₃SiH or Et₂SiH₂ in the presence of tetrabutylammonium difluorotriphenylsilicate (TBAT) in THF. For example, hexafluorobenzene underwent hydrodefluorination with Et₂SiH₂ at 60掳 to yield pentafluorobenzene in 19% yield, 1,2,4,5-tetrafluorobenzene in 70% yield, and 1,2,3,5-tetrafluorobenzene and 1,2,3,4-tetrafluorobenzene in 2% yields. The reaction involves direct hydride transfer from a hydrosilicate as the key intermediate, which is generated from a hydrosilane and a fluoride salt; the eliminated fluoride regenerates the hydrosilicate to complete the catalytic cycle. The mechanism was studied using stoichiometric reactions of silicates and using dispersion-corrected DFT calculations; hydrodefluorination likely proceeds via concerted nucleophilic aromatic substitution. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Computed Properties of C5F5N).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 鈭?8.7 脳 10鈭? cm3路mol鈭?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ路mol鈭? in the liquid phase and 140.4 kJ路mol鈭? in the gas phase. Pyridine derivatives are also useful as small-molecule 伪-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Computed Properties of C5F5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem