Tag: 100-200

In 2019,Tetrahedron included an article by Wan, Xiao-Min; Liu, Zi-Lin; Liu, Wan-Qing; Cao, Xiao-Niu; Zhu, Xinju; Zhao, Xue-Mei; Song, Bing; Hao, Xin-Qi; Liu, Guoji. Computed Properties of C6H4N2. The article was titled 《NNN pincer Ru(II)-catalyzed dehydrogenative coupling of 2-aminoarylmethanols with nitriles for the construction of quinazolines》. The information in the text is summarized as follows:

An efficient NNN pincer Ru(II)-catalyzed preparation of quinazolines via acceptorless dehydrogenative strategy was developed. Under the optimized conditions, a broad range of substituted o-aminobenzyl alcs. and (hetero)aryl or alkyl nitriles were well tolerated to afford various 2-substituted quinazolines in high yields. Subsequently, a set of control experiments was performed to elucidate the reaction mechanism, which underwent alc. oxidation, nitrile hydration and cyclocondensation steps. This protocol was featured with several advantages, such as environmental benignity, operational simplicity, broad substrate scope (compatible with aliphatic nitriles, up to 87% yield) and short reaction time (mostly in 2 h). The results came from multiple reactions, including the reaction of 4-Cyanopyridine(cas: 100-48-1Computed Properties of C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Computed Properties of C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Zhou, Pei; Wang, Lei; Wu, Guangyu; Zhou, Yuting; Hegazy, Mohammad; Huang, Xin published 《In Situ Generation of Core-Shell Protein-Based Microcapsules with Regulated Ion Absorbance Capacity》.ChemistrySelect published the findings.COA of Formula: C7H9NO The information in the text is summarized as follows:

In this study, we presented a way to generate organic/protein hybrid core-shell micro-compartment structure by in situ generating poly(o-phenylenediamine) (POPD) nanoparticles inside a robust and flexible protein-based shell. Both the size and number of the generated POPD core inside the protein microcapsules could be well varied by using different oxidants including, H2O2, tert-Bu hydroperoxide (TBHP) and glucose oxidase (GO)/ glucose (Glu). Significantly, via operating the membrane permeability by either the cleavage of the conjugated polymer or addnl. formation of tannic acid/Fe3+ complex outer shell, the adsorption capacity towards Cu2+ of the constructed multiple cores in single shell model could be well modulated. In general, our studies contribute to the establishment of an improved model with its potential applications in catalysis system, biotechnol. and biomedicine. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2COA of Formula: C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. COA of Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Manganese-Catalyzed Synthesis of Imines from Primary Alcohols and (Hetero)Aromatic Amines》 was written by Raydan, Daniel; Friaes, Sofia; Viduedo, Nuno; Santos, A. Sofia; Gomes, Clara S. B.; Royo, Beatriz; Marques, M. Manuel B.. Computed Properties of C5H5BrN2 And the article was included in Synlett on August 31 ,2022. The article conveys some information:

Herein, the synthesis of a wide variety of imines through oxidative coupling of alcs. and aromatic amines catalyzed by Mn complexes bearing NN triazole ligands was described. A wide variety of imines in excellent yields (up to 99%) was prepared Mn-based catalysts proved to be highly efficient and versatile, allowing for the first time the preparation of several imines containing N-based heterocycles. In addition to this study using 2-Bromopyridin-3-amine, there are many other studies that have used 2-Bromopyridin-3-amine(cas: 39856-58-1Computed Properties of C5H5BrN2) was used in this study.

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Computed Properties of C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Intramolecular electrochemical dehydrogenative N-N bond formation for the synthesis of 1,2,4-triazolo[1,5-a]pyridines》 was written by Li, Yong; Ye, Zenghui; Chen, Na; Chen, Zhenkun; Zhang, Fengzhi. Formula: C6H4N2This research focused ontriazolopyridine preparation green chem; amidine pyridyl electrochem dehydrogenation. The article conveys some information:

A metal- and oxidant-free intramol. dehydrogenative N-N bond formation has been developed under mild and scalable electrolytic conditions. Various valuable 1,2,4-triazolo[1,5-a]pyridines I (R1 = t-Bu, cyclopropyl, 2,6-dichlorophenyl, 2-naphthyl, pyridin-4-yl, etc.; R2 = H, Me; R3 = H, Me, Et, F, Cl, 4-methylphenyl, 2-thiophenyl; R4 = H, Me, MeO; R5 = H, Me, Cl; R3R4 = CH=CH-CH=CH) were synthesized efficiently from the readily available N-(2-pyridyl)amidines II. The reactions were conducted in a simple undivided cell under constant current conditions with n-Bu4NBr as both the redox mediator and the electrolyte. This protocol was applied to the efficient synthesis of key intermediates for anti-diabetic compounds After reading the article, we found that the author used 4-Cyanopyridine(cas: 100-48-1Formula: C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Formula: C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C12H12N2In 2022 ,《A self-oscillating gel system with complex dynamic behavior based on a time delay between the oscillations》 was published in Soft Matter. The article was written by Li, Xiuchen; Li, Jie; Zheng, Zhaohui; Deng, Jinni; Pan, Yi; Ding, Xiaobin. The article contains the following contents:

The time delay existing between the chem. oscillation and mech. oscillation (C-M delay) in a self-oscillating gel (SOG) system is observable in previous exptl. studies. However, how the C-M delay affects the dynamic behavior of a large anisotropic SOG has not been quantified or reported systematically. In this study, we observed that the oscillation period increases with a decrease in the crosslinking d. of the anisotropic SOG, and this determined whether regular mech. oscillation occurs. Unlike before, the disrupted mech. oscillations interestingly tend to be regular and periodic under visible light, which is an inhibitor for the B-Z reaction incorporating the Ru complex as a catalyst (Ru-BZ reaction). Moreover, the study of the C-M delay at different scales has far-reaching implications for intelligent soft actuators. The experimental part of the paper was very detailed, including the reaction process of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Electric Literature of C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Electric Literature of C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 4-CyanopyridineIn 2019 ,《Synthesis of Secondary Aldimines from the Hydrogenative Cross-Coupling of Nitriles and Amines over Al2O3-Supported Ni Catalysts》 was published in ACS Catalysis. The article was written by Zhou, Peng; Jiang, Liang; Wang, Shuguo; Hu, Xun; Wang, Hongming; Yuan, Ziliang; Zhang, Zehui. The article contains the following contents:

A heterogeneous Ni catalyst was discovered to be active in the synthesis of secondary cross-imines via hydrogenative coupling of nitriles and amines. The mesoporous Al2O3-supported Ni nanoparticles (abbreviated as Ni/m-Al2O3-600, where 600 represents the reduction temperature) were active in hydrogenative coupling of nitriles and amines reaction at 80 °C and 1 bar H2, affording corresponding cross-imines with yields in the range 64.1-98.1%. D. functional theory calculations reveal the hydrogenation of benzonitrile (PhCN) to benzylamine (PhCH2NH2) has higher activation energy than that for hydrogenative cross-coupling of PhCN and RNH2 on the Ni/m-Al2O3-600 catalyst, suggesting the latter reaction is more favorable. The theor. calculations are in good agreement with our exptl. results. In the experiment, the researchers used many compounds, for example, 4-Cyanopyridine(cas: 100-48-1Name: 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Name: 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 2,6-DiaminopyridineIn 2020 ,《New Pyridine-Bridged Ferrocene-Rhodamine Receptor for the Multifeature Detection of Hg2+ in Water and Living Cells》 appeared in ACS Omega. The author of the article were Guo, Yu-Shuang; Zhao, Mei; Wang, Qiong; Chen, Yu-Qin; Guo, Dian-Shun. The article conveys some information:

A challenge in the design of optical and redox-active receptors is how to combine a specific recognition center with an efficient responsive system to facilely achieve multifeature detection in biol. and environmental analyses. Herein, a novel ferrocene-rhodamine receptor conjugated with a pyridine bridge was designed and synthesized. This receptor can sensitively sense Hg2+ in aqueous media via chromogenic, fluorogenic, and electrochem. multisignal outputs with a low detection limit and fast response time. Moreover, it can be qualified as a fluorescent probe for effectively monitoring Hg2+ in living cells. A plausible recognition mode was proposed and rationalized with theor. calculations In the experiment, the researchers used many compounds, for example, 2,6-Diaminopyridine(cas: 141-86-6Application In Synthesis of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Application In Synthesis of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Xia, Jianshe; Lee, Margaret; Santos, Peter J.; Horst, Nathan; Macfarlane, Robert J.; Guo, Hongxia; Travesset, Alex published an article in Soft Matter. The title of the article was 《Nanocomposite tectons as unifying systems for nanoparticle assembly》.Related Products of 141-86-6 The author mentioned the following in the article:

Nanocomposite tectons (NCTs) are nanocomposite building blocks consisting of nanoparticle cores functionalized with a polymer brush, where each polymer chain terminates in a supramol. recognition group capable of driving particle assembly. Like other ligand-driven nanoparticle assembly schemes (for example those using DNA-hybridization or solvent evaporation), NCTs are able to make colloidal crystal structures with precise particle organization in three dimensions. However, despite the similarity of NCT assembly to other methods of engineering ordered particle arrays, the crystallog. symmetries of assembled NCTs are significantly different. In this study, we provide a detailed characterization of the dynamics of hybridizations through universal (independent of microscopic details) parameters. We perform rigorous free energy calculations and identify the persistence length of the ligand as the critical parameter accounting for the differences in the phase diagrams of NCTs and other assembly methods driven by hydrogen bond hybridizations. We also report new experiments to provide direct verification for the predictions. We conclude by discussing the role of non-equilibrium effects and illustrating how NCTs provide a unification of the two most successful strategies for nanoparticle assembly: solvent evaporation and DNA programmable assembly. In the part of experimental materials, we found many familiar compounds, such as 2,6-Diaminopyridine(cas: 141-86-6Related Products of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Related Products of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Fan, Weibin; Zhang, Yuan; Li, Yinghua; Zhang, Wei; Huang, Deguang published an article in ChemSusChem. The title of the article was 《Solvent-Free Strategy for Direct Access to Versatile Quaternary Ammonium Salts with Complete Atom Economy》.Computed Properties of C7H7NO The author mentioned the following in the article:

A solvent-free method for the synthesis of quaternary ammonium salts (QAS) such as 1-(2-Iodo-1-phenylethyl)-4-pyridinium triiodide I [R1 = Ph, 4-MeC6H4, 2-ClC6H4, etc.; R2 = H, 4-OMe, 4-C(O)OMe, etc.; X = H, N; Y = H, N] by iodoquaternization of alkenes with N-heteroarenes was reported. Its advantages lied in energy-saving and clean production by using iodine as the oxidant and manual grinding the starting materials, together with the complete atom economy and low process mass intensity (PMI) value. Generated QAS converted to pyrroles such as II [R1 = Ph, 4-MeC6H4, 2-ClC6H4, etc.; R2 = 5-SMe, C(O)Ome, C(O)Ph, etc.]. Demonstrated by 50 examples, the generated QAS was proved to be able to produce valuable chems., such as biol. protease inhibitors, anti-cancer agents, and organic fluorescent materials. In the experimental materials used by the author, we found 4-Acetylpyridine(cas: 1122-54-9Computed Properties of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Computed Properties of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Liu, Wenbo; Tao, Ouyang; Chen, Li; Ling, Yun; Zeng, Ming; Jin, Hongguang; Jiang, Dengzhao published an article in RSC Advances. The title of the article was 《Synthesis and characterization of a Cu(II) coordination-containing TAM radical as a nitroxyl probe》.Related Products of 1539-42-0 The author mentioned the following in the article:

Nitroxyl (HNO) has been identified as an important signaling mol. in biol. systems, and it plays critical roles in many physiol. processes. However, its detection remains challenging because of the limited sensitivity and/or specificity of existing detection methods. Low-frequency ESR (EPR) spectroscopy and imaging, coupled with the use of exogenous paramagnetic probes, have been indispensable techniques for the in vivo measurement of various physiol. parameters owing to their specificity, noninvasiveness and good depth of magnetic field penetration in animal tissues. However, the in vivo detection of HNO levels by EPR spectroscopy and imaging is limited due to the need for improved probes. We report the first “”turn on-response”” EPR probe for HNO utilizing a Cu(II) coordination-containing TAM radical (denoted as CuII[TD1]). Upon reaction with HNO, CuII[TD1] shows a 16.1-fold turn-on in EPR signal with a low detection limit of 1.95 μM. Moreover, low-temperature EPR spectroscopic and ESI-MS studies showed that the sensing mechanism relies on the reduction of Cu(II) by HNO. Lastly, CuII[TD1] is selective for HNO over other reactive nitrogen and oxygen species except for some reductants (Cys and Asc). This new Cu(II) coordination-containing TAM radical shows great potential for in vivo EPR HNO applications in the absence of reducing agents and provides insights into developing improved and targeted EPR HNO probes for biomedical applications. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Related Products of 1539-42-0) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Related Products of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem