Tag: 100-200

Shi, Jiale; Yuan, Tao; Zheng, Meifang; Wang, Xinchen published their research in ACS Catalysis in 2021. The article was titled 《Metal-Free Heterogeneous Semiconductor for Visible-Light Photocatalytic Decarboxylation of Carboxylic Acids》.COA of Formula: C6H4N2 The article contains the following contents:

A suitable protocol for the photocatalytic decarboxylation of carboxylic acids RC(O)OH (R = 3,5-dimethylphenyl, 2-(4-methylphenyl)ethyl, diphenylmethyl, isoquinolin-1-yl, etc.) was developed with metal-free ceramic boron carbon nitrides (BCN). With visible light irradiation, BCN oxidizes carboxylic acids to give carbon-centered radicals, which were trapped by hydrogen atom donors or employed in the construction of the carbon-carbon bond. In this system, both (hetero)aromatic and aliphatic acids proceed through the decarboxylation smoothly; and C-H, C-D, and C-C bonds are formed in moderate to high yields (35 examples, yield up to 93%). Control experiments support a radical process, and isotopic experiments show that methanol is employed as the hydrogen atom donor. Recycling tests and a gram-scale reaction elucidate the practicability of the heterogeneous ceramic BCN photoredox system. It provides an alternative to homogeneous catalysts in the valuable carbon radical intermediates formation. Moreover, the metal-free system is also applicable to late-stage functionalization of anti-inflammatory drugs, such as naproxen and ibuprofen, which enrich the chem. toolbox. After reading the article, we found that the author used 4-Cyanopyridine(cas: 100-48-1COA of Formula: C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.COA of Formula: C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Xue; Bai, Fang; Liu, Chaogan; Ma, Xiaowei; Gu, Chengzhi; Dai, Bin published their research in Organic Letters in 2021. The article was titled 《Selective Electrochemical Oxygenation of Alkylarenes to Carbonyls》.Safety of 4-Acetylpyridine The article contains the following contents:

An efficient electrochem. method for benzylic C(sp3)-H bond oxidation has been developed. A variety of methylarenes, e.g., p-chlorotoluene, methylheteroarenes, e.g., 6-methylquinoline and benzylic (hetero)methylenes, e.g., p-ethyltoluene could be converted into the desired aryl aldehydes, e.g., 4-chlorobenzaldehyde/e.g., quinoline-6-carbaldehyde and aryl ketones, e.g., 1-(p-tolyl)ethan-1-one in moderate to excellent yields in an undivided cell, using O2 as the oxygen source and lutidinium perchlorate as an electrolyte. On the basis of cyclic voltammetry studies, 18O labeling experiments, and radical trapping experiments, a possible single-electron transfer mechanism has been proposed for the electrooxidation reaction. The results came from multiple reactions, including the reaction of 4-Acetylpyridine(cas: 1122-54-9Safety of 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Safety of 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Effect of Substitution at Amine Functionality of 2,6-Diaminopyridine-Coupled Rhodamine on Metal-Ion Interaction and Self-Assembly》 was written by Panja, Santanu; Mondal, Subhendu; Ghosh, Sourav; Ghosh, Utpal; Ghosh, Kumaresh. Product Details of 141-86-6 And the article was included in ACS Omega in 2020. The article conveys some information:

2,6-Diaminopyridine-coupled rhodamines I and II have been synthesized, and the effect of substitution on amine functionality toward metal-ion interactions and self-assembly is thoroughly investigated. Both the compounds effectively recognize different metal ions of biol. significance fluorimetrically and colorimetrically with a high degree of selectivity and sensitivities. While compound I is sensitive to Fe3+ ions, compound II is responsive to both Fe3+ and Al3+ ions in aqueous CH3CN (4/1, volume/volume; 10 mM tris HCl buffer, pH 6.8). The sensing mechanism involves the metal-ion chelation-induced spirolactam ring opening of the rhodamine scaffold that results in both color and fluorescence changes, while the extent of interactions with the metal ions is truly governed by the chem. structure of the compounds Both I and II are proficient in detecting Fe3+ and Al3+ ions in human lung cancer cells (A549). As new findings, unlike I, compound II formed a faint pink gel in the toluene-hexane mixture solvent (1:1, volume/volume), and the gel state of II selectively recognizes Ag+ ions by exhibiting a phase change from gel to purple soluble Exptl. findings establish the role of the formamide moiety in forming the self-assembly. In the experiment, the researchers used many compounds, for example, 2,6-Diaminopyridine(cas: 141-86-6Product Details of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Product Details of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《One-pot synthesis of 2,2′ -dipicolylamine derived highly photoluminescent nitrogen-doped carbon quantum dots for Fe3+ detection and fingermark detection》 was published in Nanotechnology in 2020. These research results belong to Li, Quan; Guo, Zhiwei; Zhao, Xiaoyan; Zhang, Taoyi; Chen, Jing; Wei, Yun. Related Products of 1539-42-0 The article mentions the following:

The novel nitrogen-doped carbon quantum dots (N-CQDs) with high fluorescence quantum yield of 23.2% were successfully prepared via a simple hydrothermal reaction with citric acid and 2,2′ -dipicolylamine. The as-prepared blue fluorescent N-CQDs had excellent water dispersibility, and showed pH and excitation-dependent emission behaviors. Noticeably, owing to the strong interaction between the residual 2,2′ -dipicolylamine group on the surface of N-CQDs and Fe3+, the N-CQDs could be used as a turn off fluorescence probe for Fe3+ sensing through an electron transfer process. Moreover, the photoluminescent N-CQDs/poly(vinyl alc.) film was further applied for latent fingermark imaging. In the experiment, the researchers used many compounds, for example, Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Related Products of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Related Products of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis, structure and physical properties of (trans-TTF-py2)1.5(PF6)·EtOH: a molecular conductor with weak CH···N hydrogen bondings》 was published in Crystals in 2020. These research results belong to Koyama, Shohei; Kawai, Morio; Takaishi, Shinya; Yamashita, Masahiro; Hoshino, Norihisa; Akutagawa, Tomoyuki; Kanno, Manabu; Iguchi, Hiroaki. Related Products of 1122-54-9 The article mentions the following:

The studies of crystal structures with hydrogen bonds have been actively pursued because of their moderate stabilization energy for constructing unique structures. In this study, we synthesized a mol. conductor based on 2,6-bis(4-pyridyl)-1,4,5,8-tetrathiafulvalene (trans-TTF-py2). Two pyridyl groups were introduced into the TTF skeleton toward the structural exploration in TTF-based mol. conductors involved by hydrogen bonds. In the obtained mol. conductor, (trans-TTF-py2)1.5(PF6)·EtOH, short contacts between the pyridyl group and the hydrogen atom of the TTF skeleton were observed, indicating that hydrogen bonding interactions were introduced in the crystal structure. Spectroscopic measurements and conductivity measurement revealed semiconducting behavior derived from p-stacked trans-TTF-py2 radical in the crystal structure. Finally, these results are discussed with the quantified hydrogen bonding stabilization energy, and the band calculation of the crystal obtained from d. functional theory calculation4-Acetylpyridine(cas: 1122-54-9Related Products of 1122-54-9) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Related Products of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Phenyldihydropyrazolones as Novel Lead Compounds Against Trypanosoma cruzi》 were Sijm, Maarten; Siciliano de Araujo, Julianna; Kunz, Stefan; Schroeder, Susanne; Edink, Ewald; Orrling, Kristina M.; Matheeussen, An; van de Meer, Tiffany; Sadek, Payman; Custers, Hans; Cotillo, Ignacio; Martin, Julio J.; Siderius, Marco; Maes, Louis; Brown, David G.; de Nazare Correia Soeiro, Maria; Sterk, GeertJan; de Esch, Iwan J. P.; Leurs, Rob. And the article was published in ACS Omega in 2019. HPLC of Formula: 1692-25-7 The author mentioned the following in the article:

As over 6 million people are infected with Chagas disease and only limited therapeutic options are available, there is an urgent need for novel drugs. The involvement of cyclic nucleotide phosphodiesterases (PDE) in the life cycle and biol. fitness of a number of protozoan parasites has been described and several of these enzymes are thought to be viable drug targets. Within this context, a PDE-focused library was screened for its ability to affect the viability of Trypanosoma cruzi parasites. Previously reported human PDE4 inhibitor, 5-(3-(benzyloxy)-4-methoxyphenyl)-2-isopropyl-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one, was identified as a hit. Upon optimization on three positions of the phenylpyrazolone scaffold, 2-isopropyl-5-(4-methoxy-3-(pyridin-3-yl)phenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one (I) proved to be the most active compound against intracellular forms of T. cruzi (pIC50 = 6.4) with a 100-fold selectivity with respect to toxicity towards human MRC-5 cells. Evaluation on different life stages and clin. relevant T. cruzi strains revealed that the phenylpyrazolones are not active against the bloodstream form of the Y strain but show submicromolar activity against the intracellular form of the Y- and Tulahuen strains as well as against the nitro-drug resistant Colombiana strain. In vitro screening of phenylpyrazolones against TcrPDEB1, TcrPDEC and TcrCYP51 showed that there was a poor correlation between enzyme inhibition and the observed phenotypic effect. Amongst the most potent compounds both TcrCYP51 and non-TcrCYP51 inhibitors are identified, which were both equally able to inhibit T. cruzi in vitro. In addition to this study using Pyridin-3-ylboronic acid, there are many other studies that have used Pyridin-3-ylboronic acid(cas: 1692-25-7HPLC of Formula: 1692-25-7) was used in this study.

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. HPLC of Formula: 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Food Chemistry included an article by Wu, Xiaoming; Wang, Hao; Yang, Shaoxiang; Tian, Hongyu; Liu, Yongguo; Sun, Baoguo. Product Details of 98-98-6. The article was titled 《A novel coumarin-based fluorescent probe for sensitive detection of copper(II) in wine》. The information in the text is summarized as follows:

A novel coumarin-based fluorescent probe (probe 1) for the detection of copper(II) was developed. The fluorescence intensity of probe 1 showed a linear relationship with the concentration of copper(II) in the range 0-16μM (0-1.02 mg/L) and the limit of detection was 62 nM (3.94μg/L). The luminescence of probe 1 at the maximum allowable amounts of copper(II) in wine and water could be observed with the naked eye under a 365-nm UV lamp. Moreover, probe 1 was successfully used for the qual. and quant. detection of copper(II) in wine. In the experiment, the researchers used Picolinic acid(cas: 98-98-6Product Details of 98-98-6)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Product Details of 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemical Science included an article by Jin, Bo; Gallou, Fabrice; Reilly, John; Lipshutz, Bruce H.. Safety of 5-Bromo-2-chloropyridine. The article was titled 《ppm Pd-catalyzed, Cu-free Sonogashira couplings in water using commercially available catalyst precursors》. The information in the text is summarized as follows:

A new catalyst was developed for copper-free, Pd-catalyzed Sonogashira reactions at the sustainable ppm level of precious metal palladium under mild aqueous micellar conditions. Both the palladium pre-catalyst and ligand are com. available, bench stable, and highly cost-effective. The catalyst is applicable to reactions of both aryl- and heteroaryl bromides. A wide range of functional groups are tolerated and the aqueous reaction medium can be recycled. An application of this procedure to the synthesis of a key intermediate to an active pharmaceutical ingredient (ponatinib) is discussed. In the experiment, the researchers used 5-Bromo-2-chloropyridine(cas: 53939-30-3Safety of 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Safety of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Gao, Jie; Bhunia, Subhajit; Wang, Kailiang; Gan, Lu; Xia, Shanghua; Ma, Dawei published 《Discovery of N-(Naphthalen-1-yl)-N’-alkyl Oxalamide Ligands Enables Cu-Catalyzed Aryl Amination with High Turnovers》.Organic Letters published the findings.Product Details of 13534-97-9 The information in the text is summarized as follows:

In the presence of Cu2O and the oxalamide I, aryl- and heteroaryl bromides and iodides were aminated chemoselectively with primary amines (alkyl favored over aryl), ammonium hydroxide, and secondary cyclic amines and N-methylbenzylamine using KOH in EtOH at 50-80° to yield aryl- and heteroarylamines such as N-benzyl-p-anisidine in 35-98% yields using 0.1-0.5 mol% of Cu2O. The experimental part of the paper was very detailed, including the reaction process of 6-Bromopyridin-3-amine(cas: 13534-97-9Product Details of 13534-97-9)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Product Details of 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Abel, Anton S.; Averin, Alexei D.; Buryak, Alexei K.; Savelyev, Evgenii N.; Orlinson, Boris S.; Novakov, Ivan A.; Beletskaya, Irina P. published 《The Palladium-Catalyzed Heteroarylation of Adamantylalkyl Amines with Dihalogenopyridines: Scope and Limitations》.Synthesis published the findings.SDS of cas: 53939-30-3 The information in the text is summarized as follows:

Palladium-catalyzed heteroarylation of adamantylalkyl amines characterized by different steric hindrances at the amino group was carried out using 2,3-, 2,5-, 2,6-, and 3,5-dihalogenopyridines. The dependence of the results of the coupling on the nature of the halogen atoms (bromine, chlorine), their position in the pyridine ring, and on the structure of adamantylalkyl amines was investigated. The application of dichloropyridines or bromochloropyridines was shown to be advantageous over the use of dibromopyridines in many cases. Selective substitution of bromine atom in positions 3 and 5 in the presence of chlorine atom in position 2 of the pyridine ring was observed The possibility of N,N-diheteroarylation of adamantane-containing amines with 2,5-dihalogenopyridines was shown, and diamination of 2,6- and 3,5-dihalogenopyridines was demonstrated.5-Bromo-2-chloropyridine(cas: 53939-30-3SDS of cas: 53939-30-3) was used in this study.

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.SDS of cas: 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem