Tag: 100-200

Electric Literature of C5H7N3In 2022 ,《Ruthenium Complexes Bearing α-Diimine Ligands and Their Catalytic Applications in N-Alkylation of Amines, α-Alkylation of Ketones, and β-Alkylation of Secondary Alcohols》 was published in ACS Omega. The article was written by Gayathri, Sekar; Viswanathamurthi, Periasamy; Bertani, Roberta; Sgarbossa, Paolo. The article contains the following contents:

New Ru(II) complexes encompassing α-diimine ligands were synthesized by reacting ruthenium precursors with α-diimine hydrazones. The new ligands and Ru(II) complexes were analyzed by anal. and various spectroscopic methods. The mol. structures of L1 and complexes 1, 3, and 4 were determined by single-crystal XRD studies. The results reveal a distorted octahedral geometry around the Ru(II) ion for all complexes. Also, the new ruthenium complexes show efficient catalytic activity toward the C-N and C-C coupling reaction involving alcs. Particularly, complex 3 demonstrates effective conversion in N-alkylation of aromatic amines, α-alkylation of ketones, and β-alkylation of alcs. In the experimental materials used by the author, we found 2,6-Diaminopyridine(cas: 141-86-6Electric Literature of C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Electric Literature of C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridineIn 2021 ,《Reversible Stimuli-Dependent Aggregation-Induced Emission from a “”Nonfluorescent”” Amphiphilic PVDF Graft Copolymer》 was published in Langmuir. The article was written by Pakhira, Mahuya; Chatterjee, Dhruba P.; Mallick, Dibyendu; Ghosh, Radhakanta; Nandi, Arun K.. The article contains the following contents:

A poly(vinylidine fluoride) graft random copolymer of t-Bu aminoethyl methacrylate (tBAEMA) and oligo(ethylene glycol) Me ether methacrylate (OEGMA, Mn = 300) [PVDF-g-P(tBAEMA-ran-OEGMA), PVBO] is synthesized by atom transfer radical polymerization (ATRP), and PVBO is fractionated to get a highly water-soluble fraction (PVBO-1) showing a reversible on/off fluorescence behavior with gradual increase and decrease in pH, resp., achieving a maximum quantum yield of 0.18 at pH = 12. PVBO-1 dissolved in water shows large multimicellar aggregates (MMcA), but at pH 12, crumbling of larger aggregates to much smaller micelles occurs, forming nonconjugated polymer dots (NCPDs), as supported by transmission electron microscopy and dynamic light scattering study. The reversible fluorescence on/off behavior also occurs with the decrease and increase of temperature Theor. study indicates that, at high pH, most of the amino groups become neutral and exhibit a strong tendency to form aggregates from crowding of a large number of carbonyl and amine groups, minimizing the HOMO-LUMO gap, showing an absorption peak at the visible region, and generating aggregation-induced emission.4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridine) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C5H6BNO2In 2022 ,《Merging Late-Stage Diversification with Solid-Phase Peptide Synthesis Enabled by High-Throughput On-Resin Reaction Screening》 was published in ACS Catalysis. The article was written by Li, Shasha; Pissarnitski, Dmitri; Nowak, Timothy; Wleklinski, Michael; Krska, Shane W.. The article contains the following contents:

An integrated workflow is described that combines micromole-scale high-throughput experimentation (HTE) reaction screening and solid-phase peptide synthesis (SPPS) to enable rapid synthetic method development for on-resin peptide diversification. Using this new approach, we have identified several sets of robust Suzuki-Miyaura coupling conditions with complementary scope that collectively display broad coverage with respect to both resin-bound peptide substrates containing aryl halide side chains and (hetero)arylboronic acid coupling partners. We have also demonstrated the utility of this integrated SPPS/chem. diversification method by synthesizing a multidimensional library of diverse peptides in high yields. In the experimental materials used by the author, we found Pyridin-3-ylboronic acid(cas: 1692-25-7Electric Literature of C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Electric Literature of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Wu, Yao; Xie, Mo; Jin, Ji-Kang; Zhang, Zhi-Yin; Hu, Han; Tian, You-Ping; Xiao, Yu-Qing; Ning, Guo-Hong; Li, Dan; Jiang, Xuanfeng published an article in Small Structures. The title of the article was 《A Copper Iodide Cluster-Based Metal-Organic Polyhedra for Photocatalytic Click Chemistry》.Electric Literature of C7H5N The author mentioned the following in the article:

Herein, a copper(I) iodide cluster-based metal-organic polyhedra (Cu3I3)4L14 (1) ((L1 = 1,3,5-trispyridylsulfanylethyl)-2,4,6-triethylbenzene, 2-mercaptopyridine) is synthesized. Due to the abnormal geometry of [Cu3I3] SBUs, MOP 1 exhibits a half-truncated cube topol., which is rarely observed up to date. Compared with commonly used metal ion or clusters, the coordination bond between the [Cu3I3] SBU and the ligand is rather labile in solution evidenced by the theor. calculations and exptl. results. Interestingly, the liable [Cu3I3] SBU endows MOP 1 to photocatalyze the azide-alkyne cycloaddition reaction in aqueous solution with high efficiency, excellent tolerance (>80% isolated yield for 18 examples), and good recyclability. The mechanistic studies reveal a photoinduced electron transfer from the MOP to azide, which is unusual in copper-catalyzed click reactions. The results came from multiple reactions, including the reaction of 4-Ethynylpyridine(cas: 2510-22-7Electric Literature of C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Electric Literature of C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Guo, Chaoxiong; Guo, Song; Lu, Qiqing; Jiang, Zizhan; Yang, Yuzhen; Zhou, Weiqiao; Zeng, Qin; Liang, Jun; Miao, Yanqin; Liu, Yuanli published an article in Molecules. The title of the article was 《Solution-Processed Yellow Organic Light-Emitting Diodes Based on Two New Ionic Ir (III) Complexes》.Name: 4,4′-Dimethyl-2,2′-bipyridine The author mentioned the following in the article:

Two new and efficient cationic yellow-emissive Ir (III) complexes (Ir1 and Ir2) are rationally designed by using 2-(4-chloro-3-(trifluoromethyl)phenyl)-4-methylquinoline as the main ligand, and, resp., 4,4′-dimethyl-2,2′-bipyridyl and 4,4′-dimethoxy-2,2′-bipyridyl as the ancillary ligands. Both complexes show enhanced phosphorescence 546 nm with 572 nm as shoulder and high phosphorescent quantum efficiency in solution, which is in favor of efficient solution-processed phosphorescent organic light-emitting diodes. Compared with Ir2, the Ir1-based device displays excellent device performance, with maximum external quantum efficiency, current efficiency, and power efficiency of up to 7.92%, 26.32 cd/A and 15.31 lm/W, resp., thus proving that the two new ionic Ir (III) complexes exhibit great potential for future solution-processed electroluminescence. In the experiment, the researchers used many compounds, for example, 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Name: 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Name: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Denisov, Gleb L.; Nelyubina, Yulia V. published an article in Crystals. The title of the article was 《New Co-Crystals/Salts of Gallic Acid and Substituted Pyridines: An Effect of Ortho-Substituents on the Formation of an Acid-Pyridine Heterosynthon》.Recommanded Product: 141-86-6 The author mentioned the following in the article:

Co-crystallization of gallic acid with pyridines and their polyaromatic analog, quinoline, ortho-substituted by various proton-donating groups able to form hydrogen bonds, produced the only reported co-crystal of gallic acid with an ortho-substituted pyridine, 2-hydroxypyridine, as its preferred pyridone-2 tautomer, and four new crystalline products of gallic acid. These co-crystals, or gallate salts depending on the choice of the pyridine-containing compound, as predicted by the pKa rule, were identified by X-ray diffraction to feature the popular acid-pyridine heterosynthon found in most of the two-component systems of gallic acid that lack ortho-substituents in the pyridine-containing compound This single-point heterosynthon is, however, modified by one or two proton-donating ortho-substituents, which sometimes may transform into the proton acceptors in an adopted tautomer or zwitterion, to produce its two- or other multi-point variants, including a very rare four-point heterosynthon. The hydrogen bonds they form with the gallic acid species in the appropriate co-crystals/salts strongly favors the formation of the acid-pyridine heterosynthon over the acid-acid homosynthon. In the competitive conditions of multi-component systems, such a modification might be used to reduce supramol.-synthon-based polymorphism to produce new pharmaceuticals and other crystalline materials with designed properties. In the experimental materials used by the author, we found 2,6-Diaminopyridine(cas: 141-86-6Recommanded Product: 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Recommanded Product: 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Rahman, Fatema; Wushur, Imin; Malla, Nabin; Aastrand, Ove Alexander Hoegmoen; Rongved, Paal; Winberg, Jan-Olof; Sylte, Ingebrigt published an article in Molecules. The title of the article was 《Zinc-Chelating Compounds as Inhibitors of Human and Bacterial Zinc Metalloproteases》.Recommanded Product: 1539-42-0 The author mentioned the following in the article:

Inhibition of bacterial virulence is believed to be a new treatment option for bacterial infections. In the present study, we tested dipicolylamine (DPA), tripicolylamine (TPA), tris pyridine ethylene diamine (TPED), pyridine and thiophene derivatives as putative inhibitors of the bacterial virulence factors thermolysin (TLN), pseudolysin (PLN) and aureolysin (ALN) and the human zinc metalloproteases, matrix metalloprotease-9 (MMP-9) and matrix metalloprotease-14 (MMP-14). These compounds have nitrogen or sulfur as putative donor atoms for zinc chelation. In general, the compounds showed stronger inhibition of MMP-14 and PLN than of the other enzymes, with Ki values in the lower μM range. Except for DPA, none of the compounds showed significantly stronger inhibition of the virulence factors than of the human zinc metalloproteases. TPA and Zn230 were the only compounds that inhibited all five zinc metalloproteinases with a Ki value in the lower μM range. The thiophene compounds gave weak or no inhibition. Docking indicated that some of the compounds coordinated zinc by one oxygen atom from a hydroxyl or carbonyl group, or by oxygen atoms both from a hydroxyl group and a carbonyl group, and not by pyridine nitrogen as in DPA and TPA. The results came from multiple reactions, including the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Recommanded Product: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Wolowicz, Anna; Staszak, Katarzyna; Hubicki, Zbigniew published an article in Molecules. The title of the article was 《Removal of Copper(II) in the Presence of Sodium Dodecylobenzene Sulfonate from Acidic Effluents Using Adsorption on Ion Exchangers and Micellar-Enhanced Ultrafiltration Methods》.Name: Bis(pyridin-2-ylmethyl)amine The author mentioned the following in the article:

The selective removal of Cu(II) in the presence of sodium dodecylobenzene sulfonate from acidic effluents was made using the adsorption and micellar-enhanced ultrafiltration methods. Lewatit MonoPlus TP220 showed the best adsorption behavior in the systems containing Cu(II) in the presence of ABSNa50 surfactant compared to the other adsorbents (removal efficiency ≈ 100%, sorption capacity ≈ 10 mg/g). The kinetics followed the pseudo-second order kinetic equation. The Langmuir adsorption capacities were 110 mg/g (the system with ABSNa50 above CMC) and 130.38 mg/g (the system with ABSNa50 below CMC). The working ion exchange capacities were Cw = 0.0216 g/mL and Cw = 0.0135 g/mL. The copper removal by the micellar-enhanced ultrafiltration method was 76.46% (0.1 mol/L HCl). The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Name: Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Name: Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mavrova, Anelia; Dimov, Stephan; Sulikovska, Inna; Yancheva, Denitsa; Iliev, Ivan; Tsoneva, Iana; Staneva, Galya; Nikolova, Biliana published an article in 2022. The article was titled 《Design, Cytotoxicity and Antiproliferative Activity of 4-Amino-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylates against MFC-7 and MDA-MB-231 Breast Cancer Cell Lines》, and you may find the article in Molecules.SDS of cas: 100-48-1 The information in the text is summarized as follows:

Novel 4-amino-thieno[2,3-d]pyrimidine-6-carboxylates substituted at the second position were prepared by cyclocondensation of 2-amino-3-cyano-thiophene and aryl nitriles in an acidic medium. The design of the target compounds was based on structural optimization. The derivatives thus obtained were tested in vitro against human and mouse cell lines. The examination of the compound effects on BLAB 3T3 and MFC-10A cells showed that they are safe, making them suitable for subsequent experiments to establish their antitumor activity. The photoirritancy factor of the compounds was calculated Using the MTT test, the antiproliferative activity to MCF-10A, MCF-7 and MDA-MB-231 cell lines was estimated The best antiproliferative effect in respect to the MCF-7 cell line revealed compound 2 with IC50 4.3 ± 0.11 μg/mL (0.013 μM). The highest selective index with respect to MCF-7 cells was shown by compound 3 (SI = 19.3), and to MDA-MB-231 cells by compound 2 (SI = 3.7). Based on energy anal., the most stable conformers were selected and optimized by means of d. functional theory (DFT). Ligand efficiency, ligand lipophilicity efficiency and the physicochem. parameters of the target 4-amino-thienopyrimidines were determined The data obtained indicated that the lead compound among the tested substances is compound 2. The results came from multiple reactions, including the reaction of 4-Cyanopyridine(cas: 100-48-1SDS of cas: 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.SDS of cas: 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Glas, Carina; Wirawan, Ricky; Bracher, Franz published their research in Synthesis in 2021. The article was titled 《A Short Approach to N -Aryl-1,2,3,4-tetrahydroisoquinolines from N -(2-Bromobenzyl)anilines via a Reductive Amination/Palladium-Catalyzed Ethoxyvinylation/Reductive N-Alkylation Sequence》.Product Details of 128071-75-0 The article contains the following contents:

N-Aryl-1,2,3,4-tetrahydroisoquinolines are obtained via a convenient and short protocol with a broad range of substituents on both aromatic rings and high functional group tolerance. Starting from readily available ortho-brominated aromatic aldehydes and primary aromatic amines, condensation of these building blocks under reductive conditions gives N-aryl 2-bromobenzylamines. The C-3/C-4-unit of the tetrahydroisoquinoline is introduced using com. available 2-ethoxyvinyl pinacolboronate under Suzuki conditions. Finally, the obtained crude ortho-ethoxyvinyl benzylamines are cyclized via an intramol. reductive amination using the combination of triethylsilane/TFA to give the desired N-aryl-1,2,3,4-tetrahydroisoquinolines. In addition to this study using 2-Bromonicotinaldehyde, there are many other studies that have used 2-Bromonicotinaldehyde(cas: 128071-75-0Product Details of 128071-75-0) was used in this study.

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Product Details of 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem