Tag: 100-200

In 2022,Wang, Shi-yin; Chen, Guo; Chen, Ji-feng; Wang, Jin; Deng, Shao-hui; Cheng, Du published an article in RSC Advances. The title of the article was 《Glutathione-depleting polymer delivering chlorin e6 for enhancing photodynamic therapy》.Reference of 2-(2-Hydroxyethyl)pyridine The author mentioned the following in the article:

The therapeutic effect of photodynamic therapy (PDT) is highly dependent on the intracellular production of reactive oxygen species (ROS). However, the ROS generated by photosensitizers can be consumed by the highly concentrated glutathione (GSH) in tumor cells, severely impairing the therapeutic effect of PDT. Herein, we synthesized a GSH-scavenging copolymer to deliver photosensitizer chlorin e6 (Ce6). The pyridyl disulfide groups, which have faster reactivity with the thiol groups of GSH than other disulfide groups, were grafted onto a hydrophobic block to encapsulate the Ce6. Under NIR irradiation, the Ce6 generated ROS to kill tumor cells, and the pyridyl disulfide groups depleted the GSH to prevent ROS consumption, which synergistically enhanced the therapeutic effect of PDT. In vitro and in vivo experiments confirmed the combinatory antitumor effect of Ce6-induced ROS generation and the pyridyl disulfide group-induced GSH depletion. Therefore, the pyridyl disulfide group-grafted amphiphilic copolymer provides a more efficient strategy for enhancing PDT and has promising potential for clin. application. In addition to this study using 2-(2-Hydroxyethyl)pyridine, there are many other studies that have used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Reference of 2-(2-Hydroxyethyl)pyridine) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Reference of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Qiu, Jian; Wang, Cece; Zhou, Lu; Lou, Yixian; Yang, Kai; Song, Qiuling published an article in Organic Letters. The title of the article was 《Ni-Catalyzed Radical-Promoted Defluoroalkylborylation of Trifluoromethyl Alkenes To Access gem-Difluorohomoallylic Boronates》.Safety of Pyridin-3-ylboronic acid The author mentioned the following in the article:

Gem-Difluoroalkenyl boronates are attractive synthons for constructing diverse gem-difluoroalkenes and organoboron compounds However, the strategies for the construction of gem-difluorohomoallyl boronates has scarcely been described. Herein, authors develop an efficient protocol for the construction of gem-difluorohomoallylic boronates through a Ni-catalyzed radical-promoted defluoroalkylborylation of α-trifluoromethyl alkenes with α-haloboronates under mild conditions. This reaction features a broad substrate scope with good functional group tolerance and diverse transformations. In the experimental materials used by the author, we found Pyridin-3-ylboronic acid(cas: 1692-25-7Safety of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Safety of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Niu, Niu; Yu, Ying; Zhang, Zhijun; Kang, Miaomiao; Wang, Lei; Zhao, Zheng; Wang, Dong; Tang, Ben Zhong published an article in 2022. The article was titled 《A cell membrane-targeting AIE photosensitizer as a necroptosis inducer for boosting cancer theranostics》, and you may find the article in Chemical Science.SDS of cas: 2510-22-7 The information in the text is summarized as follows:

The exploration of cellular organelle-specific anchoring photosensitizers with both prominent fluorescence imaging behavior and extraordinary reactive oxygen species (ROS) production capability is highly in demand but remains a severe challenge for effective cancer theranostics involving photodynamic therapy (PDT). In this contribution, we developed a cell membrane-targeting and NIR-emission photosensitizer having an aggregation-induced emission (AIE) tendency. The AIE photosensitizer, namely TBMPEI, is capable of lighting up and ablating cancer cells by means of a necroptosis procedure enabling cell membrane rupture and DNA degradation upon light irradiation, endowing TBMPEI with impressive performance for both in vitro and in vivo fluorescence imaging-guided PDT. In addition to this study using 4-Ethynylpyridine, there are many other studies that have used 4-Ethynylpyridine(cas: 2510-22-7SDS of cas: 2510-22-7) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.SDS of cas: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Ruotong; Yuan, Chanling; Feng, Yin; Qian, Jiayi; Huang, Xiaoting; Chen, Qiutong; Zhou, Shuyuan; Ding, Yin; Zhai, Bingbing; Mei, Wenjie; Yao, Liangzhong published an article in 2021. The article was titled 《Microwave-assisted synthesis of ruthenium(II) complexes containing levofloxacin-induced G2/M phase arrest by triggering DNA damage》, and you may find the article in RSC Advances.Safety of 4,4′-Dimethyl-2,2′-bipyridine The information in the text is summarized as follows:

Ru(II) complexes have attracted increasing attention as promising antitumor agents for their relatively low toxicity, high affinity to DNA mols., and correlation with multiple targets. Meanwhile, quinolones are synthetic antibacterial agents widely used in the clin. practice. In this paper, two novel Ru(II) complexes coordinated by levofloxacin (LOFLX), [Ru(bpy)2(LOFLX)]·2ClO4 (1), and [Ru(dmbpy)2(LOFLX)]·2ClO4 (2) (bpy = 2,2′-bipyridine, dmbpy = 4,4′-dimethyl-2,2′-bipyridine) were synthesized with high efficiency under microwave irradiation and characterized by ESI-MS, 1H NMR, and 13C NMR. The binding behavior of these complexes with double-strand calf thymus DNA(CT-DNA) was investigated using spectroscopy, mol. docking, and d. functional theory calculations Results showed that 2 exhibited higher binding affinity than 1 and LOFLX. Further studies showed that 2 could induce the G2/M phase arrest of A549 cells via DNA damage. In summary, these results indicated that 2 could be developed as a potential anticancer agent in treatment of lung cancer through the induction of cell cycle arrest at G2/M phase by triggering DNA damage. After reading the article, we found that the author used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Safety of 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Safety of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Ran; Wang, Lu; An, Zhongwei; Chen, Xinbing; Chen, Pei published an article in 2021. The article was titled 《Effect of π-conjugation units on the liquid crystal and photovoltaic performance of heterocyclic pyridine-based compounds》, and you may find the article in Liquid Crystals.Computed Properties of C7H5N The information in the text is summarized as follows:

A series of new calamitic liquid crystals (LCs), 4-(5-((4-(2-(trans-4-n-alkyl- cyclohexyl)ethyl)phenyl)ethynyl)-thiophen-2-yl)pyridine comprising a cyclohexyl, a Ph and two heterocyclic (pyridine and thiophene) ring core system, terminal alkyl chain, ethane and acetylene linkers were synthesized and characterised. Their structures were confirmed by IR spectrometry (IR), NMR (NMR) and mass spectrometry (MS), and the LC properties were investigated through differential scanning calorimetry (DSC) and polarising optical microscopy (POM). Dye-sensitized solar cells (DSSCs) were assembled to evaluate the photovoltaic properties of these materials. Furthermore, three compounds and have successfully been utilized to study the effect of π-conjugation units on the LCs properties and photovoltaic performance. The results show that thienyl unit instead of Ph unit benefits photovoltaic performance, while it is not favorable to the stability of the nematic mesophase and birefringence. Meanwhile, DFT calculations of mol. conformation, frontier MO and dipole moment were used to correlate the exptl. findings.4-Ethynylpyridine(cas: 2510-22-7Computed Properties of C7H5N) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Computed Properties of C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Aboonajmi, Jasem; Panahi, Farhad; Sharghi, Hashem published their research in ACS Omega in 2021. The article was titled 《One-Pot Multicomponent Coupling Reaction of Catechols, Benzyl Alcohols/Benzyl Methyl Ethers, and Ammonium Acetate toward Synthesis of Benzoxazoles》.Reference of 2-(2-Hydroxyethyl)pyridine The article contains the following contents:

The multicomponent coupling reaction of catechol, ammonium acetate, and benzyl alc./benzyl Me ether in the presence of a Fe(III) catalyst precursor afforded benzoxazole derivatives in good to excellent yields. The notable features of this protocol are abundant availability of the catalyst system, large-scale synthesis, high diversity, and high yields of products.2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Reference of 2-(2-Hydroxyethyl)pyridine) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Reference of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis and biological evaluation of analogs of didehydroepiandrosterone as potential new anticancer agents》 was written by Solum, Eirik J.; Liekens, Sandra; Hansen, Trond Vidar. Related Products of 1692-25-7 And the article was included in Molecules in 2020. The article conveys some information:

The synthesis, cytotoxicity and inhibition of CDK8 by thirteen analogs I (Ar = C6H5, isoquinolin-5-yl, indole-5-yl, etc.) of cortistatin A are reported. These efforts revealed that the analogs with either a 6- or 7-isoquinoline or 5-indole side chain in the 17-position are the most promising anti-proliferative agents. These compounds exhibited potent cytotoxic effects in CEM, HeLa and HMEC-1 cells. All three compounds exhibited IC50 values < 10μM. The analog I (Ar = indole-5-yl) exhibited an IC50 value of 0.59μM towards the human dermal microvascular endothelial cell line (HMEC-1), significantly lower than the reference standard 2-methoxyestradiol. At a concentration at 50 nM the most potent I (Ar = isoquinolin-5-y) compound reduced the activity of CDK8 to 35%. In the part of experimental materials, we found many familiar compounds, such as Pyridin-3-ylboronic acid(cas: 1692-25-7Related Products of 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Related Products of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《C1-Symmetric PNP Ligands for Manganese-Catalyzed Enantioselective Hydrogenation of Ketones: Reaction Scope and Enantioinduction Model》 was written by Zeng, Liyao; Yang, Huaxin; Zhao, Menglong; Wen, Jialin; Tucker, James H. R.; Zhang, Xumu. Application of 1122-54-9 And the article was included in ACS Catalysis in 2020. The article conveys some information:

A family of ferrocene-based chiral PNP ligands I (R = t-Bu, cyclohexyl, Ph, R’ = Ph; R = Ph, R’ = H, i-Pr, PhCH2) has been reported. These tridentate ligands were successfully applied in Mn-catalyzed asym. hydrogenation of ketones with high enantioselectivities (92-99% ee for aryl alkyl ketones) as well as high efficiencies (TON up to 2000). In addition, dialkyl ketones could also be hydrogenated smoothly. Manganese intermediates that might be involved in the catalytic cycle were analyzed. DFT calculation was carried out to help understand the chiral induction model. The Mn/PNP catalyst could discriminate two groups with different steric properties by deformation of the phosphine moiety in the flexible 5-membered ring. The experimental process involved the reaction of 4-Acetylpyridine(cas: 1122-54-9Application of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Phosphoprotein Detection with a Single Nanofluidic Diode Decorated with Zinc Chelates》 was published in ChemPlusChem in 2020. These research results belong to Nasir, Saima; Ali, Mubarak; Ahmed, Ishtiaq; Niemeyer, Christof M.; Ensinger, Wolfgang. Category: pyridine-derivatives The article mentions the following:

We report a nanofluidic device for the label-free detection of phosphoprotein (PPn) analytes. To achieve this goal, a metal ion chelator, namely 4-[bis(2-pyridylmethyl)aminomethyl]aniline (DPA-NH2) compound was synthesized. Single asym. nanofluidic channels were fabricated in polyethylene terephthalate (PET) membranes. The chelator (DPA-NH2) mols. are subsequently immobilized on the nanochannel surface, followed by the zinc ion complexation to afford DPA-Zn2+ chelates, which act as ligand moieties for the specific binding of phosphoproteins. The success of the chem. reaction and biomol. recognition process that occur in a confined geometry can be monitored from the changes in elec. readout of the nanochannel. The nanofluidic sensor has the ability to sensitively and specifically detect lower concentrations (≥1 nM) of phosphoprotein (albumin and α-casein) in the surrounding environment as evidenced from the significant decrease in ion current flowing through the nanochannels. However, dephosphoproteins such as lysozyme and dephospho-α-casein even at higher concentration (>1μM) could not induce any significant change in the transmembrane ion flux. This observation indicated the sensitivity and specificity of the proposed nanofluidic sensor towards PPn proteins, and has potential for use in differentiating between phosphoproteins and dephosphoproteins. The results came from multiple reactions, including the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Category: pyridine-derivatives)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Catalytic Dehydrosulfurization of Thioamides to Nitriles by Gold Nanoparticles Supported on Carbon Nanotubes》 were Gopi, Elumalai; Geertsen, Valerie; Gravel, Edmond; Doris, Eric. And the article was published in ChemCatChem in 2019. Application of 100-48-1 The author mentioned the following in the article:

A gold-carbon nanotube nanohybrid was shown to act as an efficient heterogeneous catalyst in the smooth and selective conversion of thioamides to the corresponding nitriles. The reaction was performed under mild conditions (room temperature, atm. pressure of oxygen) using only a gold loading of 0.35 mol %. Substituted aromatic or aliphatic nitriles were produced in very good to excellent yields and the catalyst could be easily recycled and reused over several consecutive cycles with no loss in dehydrosulfurization performances. The experimental process involved the reaction of 4-Cyanopyridine(cas: 100-48-1Application of 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Application of 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem