Tag: 100-200

《Chromism, positional, conformational and structural isomerism in a series of Zn(II) and Cd(II) coordination polymers based on methylated azine N,N’-donor linkers》 was written by Lozovan, Vasile; Kravtsov, Victor Ch.; Gorincioi, Elena; Rotaru, Andrei; Coropceanu, Eduard B.; Siminel, Nikita; Fonari, Marina S.. Reference of 4-AcetylpyridineThis research focused onzinc cadmium pyridinylethylidenehydrazine iodide nitrate polymer preparation luminescence; thermal stability zinc cadmium pyridinylethylidenehydrazine iodide nitrate polymer; crystal structure zinc cadmium pyridinylethylidenehydrazine iodide nitrate polymer. The article conveys some information:

Seven new coordination polymers [Zn(I)2(4-bpmhz)]n (1), [Cd(I)2(4-bpmhz)]n (2), [Zn(I)2(3-bpmhz)]n (3), [Cd(I)2(3-bpmhz)2]n (4), [Zn(NO3)2(H2O)2(4-bpmhz)]n·0.5n(EtOH) (5), [Cd(NO3)2(4-bpmhz)3/2(MeOH)]n·0.5nH2O (6) and [Zn(NO3)2(3-bpmhz)2]n (7) were prepared following the reactions of the zinc and cadmium iodide or nitrate salts with the methylated azine ligands of the bis-monodentate N,N’-donor type, 1,2-bis(1-(pyridin-4-yl)ethylidene)hydrazine (4-bpmhz) and 1,2-bis(1-(pyridin-3-yl)ethylidene)hydrazine (3-bpmhz). The single-crystal X-ray diffraction studies show that compounds 1-5, and 7 display 1D chain structures, while compound 6 shows a 2D coordination network, and both 4-bpmhz and 3-bpmhz act as bidentate bridging ligands. The crystals 1 and 2 are isomorphous, and differ by the metal cation only. The single coordination chains in 1-3 have zigzag structures; they are linear in 5, while 4 and 7 display similar double-chain structures. The crystal packing in 5 and 6 provides cavities occupied by solvent mols., ethanol and water. The compounds were characterized in the solid state and in solution by spectroscopic (FTIR, UV-Vis, NMR) methods; the solid state emissive properties were studied for all compounds, while their thermal stability and behavior were investigated by thermogravimetry under inert atm., while the thermochromism for several compounds was registered and discussed. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9Reference of 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Reference of 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of Picolinic acidIn 2020 ,《Tailoring In Situ Healing and Stabilizing Post-Treatment Agent for High-Performance Inverted CsPbI3 Perovskite Solar Cells with Efficiency of 16.67%》 was published in ACS Energy Letters. The article was written by Fu, Sheng; Wan, Li; Zhang, Wenxiao; Li, Xiaodong; Song, Weijie; Fang, Junfeng. The article contains the following contents:

CsPbI3 perovskite solar cells (PSCs) have revealed promising applications for high-performance photovoltaic devices. Despite the high efficiency for regular CsPbI3 PSCs, poor stability for adverse dopants reflects the importance of the inverted. However, the inverted lag far for a phase transition and inferior CsPbI3 films. Here, we report an effective post-treatment agent, methylammonium pyridine-2-carboxylic (MAPyA), to heal and stabilize CsPbI3 films. MAPyA on CsPbI3 can decompose into methylamine (MA) gas and pyridine-2-carboxylate (PyA-) at 100°C, and MA could remove pinholes, while PyA- gifts effective passivation. In addition, oriented PyA- hinders phase transition and isolates external erosions for long-term stability. The optimized devices show the highest efficiency among the inverted CsPbI3 PSCs of 16.67%. Besides, the phase stability and robustness against external erosions get considerable promotion. More importantly, unpackaged I-rich inorganic PSCs are rarely reported with long-term maximum power point in ambient condition, and our unencapsulated device still retains 81.31% of the initial efficiency after 1800 min of outdoor operation (relative humidity 30%).Picolinic acid(cas: 98-98-6Quality Control of Picolinic acid) was used in this study.

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Quality Control of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C5H5BrN2In 2014 ,《Several human cyclin-dependent kinase inhibitors, structurally related to roscovitine, as new anti-malarial agents》 was published in Molecules. The article was written by Houze, Sandrine; Hoang, Nha-Thu; Lozach, Olivier; Le Bras, Jacques; Meijer, Laurent; Galons, Herve; Demange, Luc. The article contains the following contents:

In Africa, malaria kills one child each minute. It is also responsible for about one million deaths worldwide each year. Plasmodium falciparum, is the protozoan responsible for the most lethal form of the disease, with resistance developing against the available anti-malarial drugs. Among newly proposed anti-malaria targets, are the P. falciparum cyclin-dependent kinases (PfCDKs). There are involved in different stages of the protozoan growth and development but share high sequence homol. with human cyclin-dependent kinases (CDKs). We previously reported the synthesis of CDKs inhibitors that are structurally-related to (R)-roscovitine, a 2,6,9-trisubstituted purine, and they showed activity against neuronal diseases and cancers. In this report, we describe the synthesis and the characterization of new CDK inhibitors, active in reducing the in vitro growth of P. falciparum (3D7 and 7G8 strains). Six compounds are more potent inhibitors than roscovitine, and three exhibited IC50 values close to 1 μM for both 3D7 and 7G8 strains. Although, such mols. do inhibit P. falciparum growth, they require further studies to improve their selectivity for PfCDKs. In addition to this study using 6-Bromopyridin-3-amine, there are many other studies that have used 6-Bromopyridin-3-amine(cas: 13534-97-9COA of Formula: C5H5BrN2) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.COA of Formula: C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 98-98-6In 2019 ,《Palladium-Catalyzed C8-H Acylation of 1-Naphthylamines with Acyl Chlorides》 appeared in Organic Letters. The author of the article were Yu, Xiaomeng; Yang, Fan; Wu, Yusheng; Wu, Yangjie. The article conveys some information:

A facile and efficient protocol for palladium-catalyzed regioselective C8-H acylation of 1-naphthylamine derivatives with acyl chlorides has been developed. The reaction exhibits broad functional group tolerance, and both aromatic and α,β-unsaturated acyl chlorides can be effectively coupled with 1-naphthylamines. Moreover, the picolinamide moiety as a bidentate directing group likely plays a key role in this regioselective transformation. In the part of experimental materials, we found many familiar compounds, such as Picolinic acid(cas: 98-98-6SDS of cas: 98-98-6)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.SDS of cas: 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 128071-75-0In 2022 ,《Iodine-Mediated C=C Double Bond Cleavage toward Pyrido[2,1-b]quinazolinones》 appeared in Organic Letters. The author of the article were Hao, Wei; Li, Kailu; Ye, Chenyang; Yu, Wenquan; Chang, Junbiao. The article conveys some information:

A transition-metal-free C=C double bond cleavage reaction employing mol. iodine is described. In the presence of K2CO3 as the base, I2-mediated C = C bond cleavage followed by intramol. annulation of N-(2-vinylaryl)pyridin-2-amine substrates, e.g., N-(2-vinylnaphthalen-1-yl)pyridin-2-amine produces pyrido[2,1-b]quinazolinones, e.g., 7H-benzo[h]pyrido[2,1-b] quinazolin-7-one and related heterocyclic compounds This reaction can be completed on a gram scale and has been successfully applied to the synthesis of compounds with important biol. properties such as 11H-pyrido[2,1-b]quinazolin-11-one and 2-methyl-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid, including efflux pump inhibitory and antiallergic activities. In the experimental materials used by the author, we found 2-Bromonicotinaldehyde(cas: 128071-75-0HPLC of Formula: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.HPLC of Formula: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C7H9NOIn 2018 ,《Palladium-Catalyzed C-O Cross-Coupling of Primary Alcohols》 appeared in Organic Letters. The author of the article were Zhang, Hong; Ruiz-Castillo, Paula; Buchwald, Stephen L.. The article conveys some information:

Two catalyst systems are described, which together provide mild and general conditions for the Pd-catalyzed C-O cross-coupling of primary alcs. For activated substrates, such as electron-deficient aryl halides, the com. available ligand I [R = R’ = Bu-t] promotes efficient coupling for a variety of alc. nucleophiles. In the case of unactivated electrophiles, such as electron-rich aryl halides, the new ligand I [R = adamantyl, R’ = cyclohexyl] was developed to improve these challenging C-O bond-forming reactions. In the experiment, the researchers used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Formula: C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 3510-66-5In 2020 ,《Synthesis of Benzo-Fused 11H-Pyrido[2,1-b]quinazolin-11-ones by a Buchwald-Hartwig Coupling/Pyridine Dearomatization Sequence in Eucalyptol》 appeared in Synthesis. The author of the article were Campos, Joana F.; Pacheco-Benichou, Alexandra; Fruit, Corinne; Besson, Thierry; Berteina-Raboin, Sabine. The article conveys some information:

The synthesis of a new library of polyheterocyclic 11H-pyrido[2,1-b]quinazolin-11-one derivatives was investigated. Satisfactory conditions were obtained via sequential C-N Buchwald-Hartwig coupling and pyridine dearomatization. In this work, traditional solvents were replaced by the bio-sourced eucalyptol, confirming the interest in it as a green solvent in chem. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-5-methylpyridine(cas: 3510-66-5Recommanded Product: 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Recommanded Product: 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Su, Fangyao; Zhao, Qianrui; Wang, Mengzhuo; Zhao, Mingzhang; Ren, Yihe; Zhu, Binghan; Chen, Haoran; Lai, Miao; Zhao, Mingqin published an article in ChemistrySelect. The title of the article was 《A Convenient Esterification of N-Heteroarene Methanols via C-CN Bond Cleavage of Benzoyl Cyanides as Acylating Sources》.Formula: C7H9NO The author mentioned the following in the article:

An efficient and straightforward methodol. for the esterification of various N-heteroarene methanols using benzoyl cyanides as acylating sources through a simply mixing conditions has been reported. The acyl groups were in-situ generated via chemoselective C-CN bond cleavage to give the N-heteroarenemethyl esters. This process features in readily accessible starting materials and offers an easy operational procedure, and broad substrate scope with excellent selectivity. In the experiment, the researchers used many compounds, for example, 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Formula: C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Fischer, Christian; Veprek, Nynke A.; Peitsinis, Zisis; Ruhmann, Klaus-Peter; Yang, Chao; Spradlin, Jessica N.; Dovala, Dustin; Nomura, Daniel K.; Zhang, Yingkai; Trauner, Dirk published an article in Synlett. The title of the article was 《De novo Design of SARS-CoV-2 Main Protease Inhibitors》.Related Products of 2510-22-7 The author mentioned the following in the article:

The COVID-19 pandemic prompted many scientists to investigate remedies against SARS-CoV-2 and related viruses that are likely to appear in the future. As the main protease of the virus, M Pro, is highly conserved among coronaviruses, it has emerged as a prime target for developing inhibitors. Using a combination of virtual screening and mol. modeling, we identified small mols. that were easily accessible and could be quickly diversified. Biochem. assays confirmed a class of pyridones as low micromolar noncovalent inhibitors of the viral main protease. In the experiment, the researchers used many compounds, for example, 4-Ethynylpyridine(cas: 2510-22-7Related Products of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Zhang, Lin; Zhang, Ling; Chen, Qian; Li, Linlin; Jiang, Jian; Sun, Hao; Zhao, Chong; Yang, Yuanyong; Li, Chun published an article in Organic Letters. The title of the article was 《Cinchona-Alkaloid-Derived NNP Ligand for Iridium-Catalyzed Asymmetric Hydrogenation of Ketones》.HPLC of Formula: 1122-54-9 The author mentioned the following in the article:

Herein, a series of novel and easily accessed cinchona-alkaloid-based NNP ligands I [R = cyclohexyl, Ph, 2-MeOC6H4, etc.; R1 = H, MeO] was developed in two steps. By combining [Ir(COD)Cl]2, 39 ketones including aromatic, heteroaryl, and alkyl ketones were hydrogenated, all affording valuable chiral secondary alcs. with 96.0-99.9% ee. A plausible reaction mechanism was discussed by NMR, HRMS, DFT and an activating model involving trihydride was verified. In the experimental materials used by the author, we found 4-Acetylpyridine(cas: 1122-54-9HPLC of Formula: 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. HPLC of Formula: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem