Tag: 100-200

In 2022,Krah, Sabrina; Kachel, Iris; Trapp, Oliver published an article in ChemCatChem. The title of the article was 《Electron-Rich Silicon Containing Phosphinanes for Rapid Pd-Catalyzed C-X Coupling Reactions》.Electric Literature of C5H6BNO2 The author mentioned the following in the article:

Novel silicon-containing phosphine, 4,1-phosphasilinane 2-TripC6H4P(CH2CH2)2SiMe2 (SabPhos, Trip = 2,4,6-iPr3C6H2) was prepared as a ligand for palladium-catalyzed coupling reactions. Palladium-catalyzed cross-coupling reactions are among the most useful and efficient methods for direct access to complex structures in organic synthesis. However, heteroatom-containing compounds can complicate such coupling reactions due to their competitive coordination with the palladium catalyst and electronic effects. As a result, good yields are often only obtained under harsher reaction conditions, such as high temperatures and long reaction times. Here the design of a highly active phosphine ligand is reported that provides excellent yields for C-N coupling reactions at ambient temperature Incorporation of the phosphorus atom into a cyclohexane ring maintains the pyramidal structure of the phosphorus while reducing steric hindrance. This, and a silicon atom in the cyclohexane moiety, results in an electron-rich phosphinane ligand. This novel silicon containing SabPhos ligand can be obtained in excellent yields in a straightforward synthesis. In palladium catalyzed reactions, this ligand facilitates the coupling of a broad range of heteroaryl chlorides via C-C bonds with boronic acids and C-N bonds with secondary amines in excellent yields under mild conditions. In the experiment, the researchers used 2-Pyridinylboronic acid(cas: 197958-29-5Electric Literature of C5H6BNO2)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Electric Literature of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Hua, Manli; Song, Jinliang; Huang, Xin; Fan, Honglei; Wu, Tianbin; Meng, Qinglei; Zhang, Zhanrong; Han, Buxing published an article in Chemical Science. The title of the article was 《Highly efficient C(CO)-C(alkyl) bond cleavage in ketones to access esters over ultrathin N-doped carbon nanosheets》.Name: 4-Acetylpyridine The author mentioned the following in the article:

A series of porous and ultrathin N-doped carbon nanosheets (denoted as CN-X, where X represents the pyrolysis temperature) as heterogeneous metal-free catalysts was reported. It was observed that the fabricated CN-800 could efficiently catalyze the oxidative cleavage of the C(CO)-C bond in various ketones RC(O)CH3 [R = Ph, naphthalen-1-yl, thiophen-2-yl, pyridin-4-yl, etc.] to generate the corresponding Me esters RC(O)OCH3 at 130°C without using any addnl. base. Detailed investigations revealed that the higher content and electron d. of the graphitic-N species contributed to the excellent performance of CN-800. The high surface area affording active sites that are more easily accessed, could also enhance the catalytic activity. The catalysts have great potential for practical applications because of some obvious advantages, such as low cost, neutral reaction conditions, heterogeneous nature, high efficiency, and broad ketone scope. This is the first work on efficient synthesis of Me esters via oxidative esterification of ketones over heterogeneous metal-free catalysts. After reading the article, we found that the author used 4-Acetylpyridine(cas: 1122-54-9Name: 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Name: 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Yu, Hao; Lin, Yu-Diao; Liu, Zheng-Yi; Sun, Yan-Qiong; Zheng, Shou-Tian published an article in Inorganic Chemistry. The title of the article was 《A Three-Dimensional (3D) Indium-Containing Polyoxoniobate Framework Based on {In5Nb71}n Helical Pillars》.Computed Properties of C5H6BNO2 The author mentioned the following in the article:

A rare 3D indium-containing polyoxoniobate framework {H9[Cu(en)2(H2O)2][Cu(en)2]12[In(en)]5[Nb23-O65(OH)3(H2O)2]}{Nb24O67(OH)2(H2O)3}2·68H2O (1), based on the In-containing polyoxoniobate cluster, {[In(en)]5[Nb23O65(OH)3(H2O)2][Nb24O67(OH)2(H2O)3]2}35- ({In5Nb71}) and [Cu(en)2]2+ linkers was successfully synthesized. The nest-like cluster {In5Nb71} is constructed from one brand-new V-shaped {Nb23O70}, two triangle-shaped {Nb24O72} and five [In(en)]3+. The [In(en)] fragments link {Nb24O72} and {Nb23O70} units into unique {In5Nb71}n helical pillars. The copper-amine complexes connect the {In5Nb71}n helical pillars into a three-dimensional (3D) inorganic-organic hybrid In-Cu-containing framework. This material also exhibits good ionic conductivity and vapor adsorption capacity properties.Pyridin-3-ylboronic acid(cas: 1692-25-7Computed Properties of C5H6BNO2) was used in this study.

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Computed Properties of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yilmaz, Cemile; Gokmen, Vural published an article in 2021. The article was titled 《Formation of amino acid derivatives in white and red wines during fermentation: Effects of non-Saccharomyces yeasts and Oenococcus oeni》, and you may find the article in Food Chemistry.Application In Synthesis of Picolinic acid The information in the text is summarized as follows:

This study aimed to investigate the effect of com. non-Saccharomyces yeasts and Oenococcus oeni on the formation of amino acid derivatives, some of which have neuroactive properties, during fermentation in laboratory-scale processing of white and red wines. Changes in the content of amino acid derivatives during fermentation of large-scale white and red wines were also evaluated. The highest kynurenic, picolinic, and quinolinic acid concentrations were observed in white wine fermented with Torulaspora delbrueckii, Kluyveromyces thermotolerans and Saccharomyces cerevisiae simultaneously. No changes in the content of picolinic and kynurenic acid were observed during large-scale white wine fermentation Tryptophan Et ester concentration in all wines increased significantly during alc. fermentation Natural and O. oeni malolactic fermentation did not alter the content of picolinic acid, a neuroprotective compound, in red wine. The decrease in the content of tyramine, phenylethylamine, and dopamine in laboratory-scale white wines was observed during alc. fermentation The results came from multiple reactions, including the reaction of Picolinic acid(cas: 98-98-6Application In Synthesis of Picolinic acid)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Application In Synthesis of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yen-Pon, Expedite; Buttard, Floris; Frederic, Lucas; Thuery, Pierre; Taran, Frederic; Pieters, Gregory; Champagne, Pier Alexandre; Audisio, Davide published an article in 2021. The article was titled 《Heterohelicenes through 1,3-Dipolar Cycloaddition of Sydnones with Arynes: Synthesis, Origins of Selectivity, and Application to pH-Triggered Chiroptical Switch with CPL Sign Reversal》, and you may find the article in JACS Au.SDS of cas: 128071-75-0 The information in the text is summarized as follows:

Regioselective access to heterohelicenes through the 1,3-dipolar cycloaddition of sydnones with arynes was described. Novel access to sydnones and poly(hetero)aromatic aryne precursors allowed the introduction of chem. diversity over multiple positions of the helical scaffolds. The origins of the unconventional regioselectivity during the cycloaddition steps was systematically investigated using d. functional theory (DFT) calculations, unveiling the key features that control this reactivity, namely, face-to-face (π···π) or edge-to-face (C-H···π) interactions, primary orbital interactions and distortion from coplanarity in the transition structures (TSs) of the transformation. From the library of 24 derivatives synthesized, a pyridyl containing derivative displayed reversible, red-shifted, pH-triggered chiroptical switching properties, with CPL-sign reversal. It was found that protonation of the helicene causes a change of the angle between the elec. and magnetic dipole moments related to the S1 → S0 transition, resulting in this rare case of reversible CPL sign inversion upon application of an external stimulus.2-Bromonicotinaldehyde(cas: 128071-75-0SDS of cas: 128071-75-0) was used in this study.

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. SDS of cas: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sun, Deli; Ma, Guobin; Zhao, Xinluo; Lei, Chuanhu; Gong, Hegui published their research in Chemical Science in 2021. The article was titled 《Nickel-catalyzed asymmetric reductive arylation of α-chlorosulfones with aryl halides》.Formula: C5H3BrClN The article contains the following contents:

An asym. Ni-catalyzed reductive cross-coupling of aryl/heteroaryl halides with racemic α-chlorosulfones to afford enantioenriched sulfones I [R1 = Me, Ph, 2-thienyl, etc.; R2 = Me, n-Bu, Bn, etc.; Ar = 4-MeOOCC6H4, 2-methoxy-pyridin-5-yl, 2-naphthyl, etc.] was reported. The reaction tolerated a variety of functional groups under mild reaction conditions, which complements current methods. The utility of this work was demonstrated by facile late-stage functionalization of com. drugs.5-Bromo-2-chloropyridine(cas: 53939-30-3Formula: C5H3BrClN) was used in this study.

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Formula: C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kunfi, Attila; Jablonkai, Istvan; Gazdag, Tamas; Mayer, Peter J.; Kalapos, Peter Pal; Nemeth, Krisztina; Holczbauer, Tamas; London, Gabor published their research in RSC Advances in 2021. The article was titled 《A photoresponsive palladium complex of an azopyridyl-triazole ligand: light-controlled solubility drives catalytic activity in the Suzuki coupling reaction》.Product Details of 13534-97-9 The article contains the following contents:

Herein, the design and synthesis of a click-derived Pd-complex merged with a photoswitchable azobenzene unit is presented. While in the trans-form of the switch the complex showed limited solubility, the photogenerated cis-form rendered the mol. soluble in polar solvents. This light-controllable solubility was exploited to affect the catalytic activity in the Suzuki coupling reaction. The effect of the substrate and catalyst concentration and light intensity on the proceeding and outcome of the reaction was studied. Dehalogenation of the aryl iodide starting material was found to be a major side reaction; however, its occurrence was dependent on the applied light intensity. The experimental process involved the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9Product Details of 13534-97-9)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Product Details of 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Transition-Metal-Free Coupling Reactions: PPh3-Promoted Sonogashira-Type Cross-Couplings of Heteroaryl Halides with Terminal Alkynes》 was published in ChemistrySelect in 2020. These research results belong to Tian, Wan-Fa; He, Ke-Han; Li, Na; Fen; Liu; Mai, Xi; Feng, Li-Hua; He, Yong-Qin. Name: 2-Bromo-5-methylpyridine The article mentions the following:

Synthesis phenylethynyl heteroaryl I [Ar1 = 2-pyridyl, 6-Me-3-pyridyl, 3-quinolyl, etc.; Ar2 = Ph 2-FC6H4, 4-MeOC6H4, etc.] via Sonogashira-type cross-coupling reaction of heteroaryl halides with terminal alkynes under mild transition-metal-free conditions using PPh3 and Cs2CO3/NEt3 was reported, a wide range of functional groups was tolerated under optimized conditions. Furthermore, the protocol would be extended to the Suzuki-type cross-coupling of heteroaryl halides with phenylboronic acid, to gave the Ph heteroaryl II [Ar3 = 3-pyridyl, 5-pyrimidinyl, 3-quinolyl, etc.] in good to excellent yields. A test reaction on gram scale delivered the product in reasonably high yield and thus had the potential of promising applications in drug discovery and functional materials. In the experiment, the researchers used 2-Bromo-5-methylpyridine(cas: 3510-66-5Name: 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Name: 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Reduced phosphomolybdate hybrids as efficient visible-light photocatalysts for Cr(VI) reduction》 were Hou, Lin; Zhang, Yaqi; Ma, Yuanyuan; Wang, Yali; Hu, Zhifei; Gao, Yuanzhe; Han, Zhangang. And the article was published in Inorganic Chemistry in 2019. Recommanded Product: 1134-35-6 The author mentioned the following in the article:

Photocatalytic reduction of hexavalent chromium [Cr(VI)] is a promising technol. approach to highly efficiently and environmentally tackle the problem of Cr(VI) pollution, in which the key challenge is in the development of effective photocatalysts. In this work, highly reduced hourglass-type molybdophosphate hybrids with the formulas [Zn(mbpy)(H2O)2]2[Zn(mbpy)(H2O)]2{Zn[P4Mo6O31H7]2}·9H2O (1), [Na(H2O)2]2[Zn(mbpy)(H2O)]2[Zn(mbpy)(H2O)2]2{Zn[P4Mo6O31H6]2}·15H2O (2), and (H2mbpy){[Zn(mbpy)(H2O)]2[Zn(H2O)]2}{Zn[P4Mo6O31H6]2}·10H2O (3) (mbpy = 4,4′-dimethyl-2,2′-bipyridine) have been hydrothermally synthesized and used as photocatalysts for the reduction of Cr(VI) under mild conditions. Structural anal. showed that the inorganic moieties in crystals 1-3 are composed of a unique 0D single cluster form, a 1D chainlike structure, and a 2D-layered structure, resp., in which polyanions were constructed by hourglass-type molybdophosphates with one Zn(II) ion as the central metal. These hybrids displayed good performance for the photocatalytic reduction of Cr(VI) by virtue of their wide visible-light adsorption, suitable energy band structures, and specific spatial arrangements of polyanionic species. Among them, hybrid 2 exhibits the best photocatalytic performance with a Cr(VI) reduction conversion rate of almost 94.7% within 180 min of reaction time. The photocatalysis mechanism investigation revealed that highly reduced hourglass-type molybdophosphate clusters can be illuminated by visible light. The photoinduced electrons induced by hourglass-type polyanions can directly reduce Cr(VI) to Cr(III), while the photogenerated holes are used to oxidize the sacrificial agent iso-Pr alc. to acetone. This work provides new guidance for the design and preparation of highly efficient photocatalysts for the reduction of Cr(VI). The hourglass-type polyanion-based hybrids have excellent photocatalytic performance that may provide some new guidance for the design and preparation of highly efficient Cr(VI) removal photocatalysts. In addition to this study using 4,4′-Dimethyl-2,2′-bipyridine, there are many other studies that have used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Recommanded Product: 1134-35-6) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Recommanded Product: 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Copper (0)/Selectfluor system-catalyzed tandem annulation/aromatization of o-aryl benzenesulfonylimides: facile synthesis of 6H-phenanthridines》 were Zheng, Limeng; Shi, Dongdong; Bao, Hanyang; Lin, Yunkun. And the article was published in Youji Huaxue in 2019. Application In Synthesis of 2-Bromonicotinaldehyde The author mentioned the following in the article:

A facile and efficient method for the synthesis of 6H-phenanthridines I (R = H, F; R1 = H, Cl, F, Br, Me; R2 = H, Me, Cl, F; R3 = H, Cl; R4 = H, Me, i-Pr, Ph, etc.; R3R4 = -CH=CH-CH=CH-) has been successfully developed involving a copper (0)/Selectfluor system-catalyzed tandem annulation/aromatization of o-aryl benzenesulfonylimides 2-(3-R3-4-R4C6H3)-4-R1-5-R2-6-RC6HCH=NSO2Ph. A variety of substituted 6H-phenanthridines I was synthesized in moderate to good yields under mild reaction conditions. Mechanistic experiments revealed that the reaction might involve an oxycupration of C=N bond followed by an intramol. C-H bond amination as the key steps triggered by an in situ generated copper species XCuOH (X = F or BF4) from the Cu (0)/Selectfluor system. In the experimental materials used by the author, we found 2-Bromonicotinaldehyde(cas: 128071-75-0Application In Synthesis of 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Application In Synthesis of 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem