Tag: 100-200

In 2012,Reis, Lindomar A.; Ligiero, Carolina B. P.; Andrade, Acacio A.; Taylor, Jason G.; Miranda, Paulo C. M. L. published 《Preparation of polyaminopyridines using a CuI/-proline-catalyzed C-N polycoupling reaction》.Materials published the findings.Product Details of 13534-97-9 The information in the text is summarized as follows:

Polyaminopyridines (PAPy) were chem. prepared from amino-bromopyridines by a CuI/-proline-catalyzed C-N polycondensation reaction. The formation of the polymer was confirmed by GPC, x-ray diffraction, XRF, FTIR, UV-vis (λmax = 400 nm), 1H and 13C NMR. The number-average mol. weights (Mn) were estimated by end-group anal. using x-ray fluorescence (up to 6000 Da). TGA anal. of PAPy with higher Mn showed greater thermal stability up to 170 °C. Viscosity measurements of polymer in formic acid at 30 °C indicated a polyelectrolyte nature of PAPy solutions Furthermore, the amorphicity of the material was observed by x-ray diffraction anal. In addition to this study using 6-Bromopyridin-3-amine, there are many other studies that have used 6-Bromopyridin-3-amine(cas: 13534-97-9Product Details of 13534-97-9) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Product Details of 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2020,RSC Advances included an article by Recio, Javier; Filace, Fabiana; Gala, Elena; Perez-Redondo, Adrian; Alvarez-Builla, Julio; Burgos, Carolina. Reference of 2-Bromopyridin-3-amine. The article was titled 《Studies on the preparation of aminobipyridines and bipyridine sultams via an intramolecular free radical pathway》. The information in the text is summarized as follows:

A variety of aminated bipyridines and bipyridine sultams are prepared by intramol. radical [1,5]-ipso and [1,6]-ortho substitutions, using a sulfonamide as a linker to connect the pyridyl radical to the pyridine under attack. For the cases studied, different regiochemistries were observed depending on the initial position of the sulfonamide linker. In the experiment, the researchers used 2-Bromopyridin-3-amine(cas: 39856-58-1Reference of 2-Bromopyridin-3-amine)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Reference of 2-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,RSC Advances included an article by Qian, Yingjie; Jeong, Sang Yung; Baeck, Sung-Hyeon; Jin, Myung-Jong; Shim, Sang Eun. Recommanded Product: 39856-58-1. The article was titled 《A palladium complex confined in a thiadiazole-functionalized porous conjugated polymer for the Suzuki-Miyaura coupling reaction》. The information in the text is summarized as follows:

Porous organic polymers (POPs) with well-distributed and tunable functional groups acting as ligands for specific reactions are promising supports for confining useful novel metals such as Pd, Au, and Pd. Herein, a thiadiazole-containing POP has been successfully synthesized and used for immobilizing Pd species. Pd immobilized inside the micropores (2.3 nm) of the POP material is easily prepared owing to a large amount of the strong anchoring group, thiadiazole, which is intrinsically distributed in the as-prepared POP. The rigid thiadiazole-containing polymer can stabilize the central metal rather than poisoning it. The as-prepared catalyst shows excellent catalytic activity in Suzuki-Miyaura coupling reactions under mild reaction conditions and low catalyst loading. Importantly, the intrinsically distributed thiadiazole ligands can stabilize the Pd moiety, preventing aggregation and leaching, and afford excellent catalytic lifetimes. Consequently, the catalyst can be reused 10 times without a significant loss of its catalytic activity. In the experimental materials used by the author, we found 2-Bromopyridin-3-amine(cas: 39856-58-1Recommanded Product: 39856-58-1)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Recommanded Product: 39856-58-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of 2-Bromopyridin-3-amineOn November 5, 2021 ,《Selective Thiocyanation and Aromatic Amination To Achieve Organized Annulation of Enaminone with Thiocyanate》 appeared in Organic Letters. The author of the article were Zhang, Jun; She, Mengyao; Liu, Lang; Feng, Xukai; Li, Yao; Liu, Hua; Zheng, Tingting; Leng, Xin; Liu, Ping; Zhang, Shengyong; Li, Jianli. The article conveys some information:

A tandem insertion of thiocyanate to enamine was performed for the regioselective synthesis of multisubstituted benzoimidazo[2,1-b]thiazoles. This method was shown to be effective in addressing the issue of isomerization encountered in common strategies. With a change made to the leading group on the aniline fragment of enamine, the reaction achieved different transformations, thus enabling multisubstituted benzo[4,5]imidazo[2,1-b]thiazoles and thiazoles in satisfactory yields. The experimental part of the paper was very detailed, including the reaction process of 2-Bromopyridin-3-amine(cas: 39856-58-1Quality Control of 2-Bromopyridin-3-amine)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Quality Control of 2-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Guan, Qixia; Guo, Hao; Xue, Rui; Wang, Mingyue; Wu, Ning; Cao, Yujuan; Zhao, Xin; Yang, Wu published an article in 2021. The article was titled 《Electrochemical sensing platform based on covalent organic framework materials and gold nanoparticles for high sensitivity determination of theophylline and caffeineã€? and you may find the article in Microchimica Acta.Name: 2,6-Diaminopyridine The information in the text is summarized as follows:

A new covalent organic framework (COF) has been prepared with 1,3,6,8-tetra(4-formyl phenyl) pyrene (TFPPy) and 2,6-diaminopyridine (DP) as building units through a Schiff base reaction by a simple tube oven heating procedure and the structure of the COF has been characterized in detail. The obtained DP-Py COF is employed to fabricate a novel electrochem. sensing platform for sensitive and selective determination of theophylline (TP) and caffeine (CAF) simultaneously through compounding with AuNPs; the peak positions of TP and CAF are 0.95 V and 1.28 V, resp. The synergistic effect between DP-Py COF and AuNPs effectively enhances the anal. sensitivity for the target analytes. Under the optimized exptl. conditions, the electrochem. sensing platform shows a sensitive voltammetric response and wide linear range to both TP and CAF, and the detection limits are 0.19μM and 0.076μM (S/N = 3), resp. This method has been successfully used for the determination of TP and CAF in compound paracetamol capsules and black tea samples. The recovery and relative standard deviations (RSD) of TP are 99.3âˆ?01% and 97.6âˆ?01% and 1.3âˆ?.0% and 1.3âˆ?.1%, resp., and the recovery and RSD of CAF are 96.1âˆ?02% and 99.4âˆ?04% and 2.8âˆ?.9% and 1.7âˆ?.2%, resp. Compared with traditional detection methods, the constructed sensing platform has better performance and is expected to be widely used also in other real sample analyses. In addition to this study using 2,6-Diaminopyridine, there are many other studies that have used 2,6-Diaminopyridine(cas: 141-86-6Name: 2,6-Diaminopyridine) was used in this study.

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Name: 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Hang; Tang, Xiao; Ye, Hebo; Wang, Xinchang; Zheng, Hao; Hai, Yu; Cao, Xiaoyu; You, Lei published their research in Organic Letters in 2021. The article was titled 《Effects of n â†?π* Orbital Interactions on Molecular Rotors: The Control and Switching of Rotational Pathway and Speedã€?Category: pyridine-derivatives The article contains the following contents:

The role of n â†?π* orbital interactions in the rotational pathway and barrier of biaryl-based mol. rotors was elucidated through a combined exptl. and computational study. The n â†?π* interaction in the transition state can lead to the acceleration of rotors. The competition between the n â†?π* interaction and hydrogen bonding further enabled the reversal of the pathway and greasing/braking the rotor in response to acid/base stimuli, thereby creating a switchable mol. rotor. In the experiment, the researchers used 2-Bromonicotinaldehyde(cas: 128071-75-0Category: pyridine-derivatives)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yao, Xing-Qi; Tong, Wen-Yan; Wang, Kang; Qu, Shuanglin; Wang, Jianbo published their research in Organometallics in 2021. The article was titled 《Azacycle-Directed Formal Aromatic C(sp2)-H Insertion with Cr(0) Fischer Carbene Complex via Oxidative Hydrogen Migrationã€?HPLC of Formula: 3510-66-5 The article contains the following contents:

An azacycle-directed intermol. aromatic C(sp2)-H functionalization of Cr(0) Fischer carbene complexes under catalyst-free conditions is reported. Arenes with pyridines, pyrimidine, and pyrazole as directing groups reacted with chromium(0) carbene complexes in good yields and excellent regioselectivities. According to the mechanistic studies based on experiments and computations with d. functional theory (DFT), the reaction is proposed to follow an unconventional mechanism via oxidative hydrogen migration and reductive elimination, which is different from the classical electrophilic substitution mechanism.2-Bromo-5-methylpyridine(cas: 3510-66-5HPLC of Formula: 3510-66-5) was used in this study.

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.HPLC of Formula: 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A simple and efficient asymmetric hydrogenation of heteroaromatic ketones with iridium catalyst composed of chiral diamines and achiral phosphinesã€?was written by Li, Chun; Lu, Xunhua; Wang, Mengna; Zhang, Ling; Jiang, Jian; Yan, Shunfa; Yang, Yuanyong; Zhao, Yonglong; Zhang, Lin. HPLC of Formula: 1122-54-9 And the article was included in Tetrahedron Letters in 2020. The article conveys some information:

An efficient iridium catalyst composed of a simple and com. available o-methoxytriphenylphosphine and 9-Amino (9-deoxy) epi-cinchonine was applied to the asym. hydrogenation of heteroaromatic ketones. A range of simple heteroaromatic ketones were hydrogenated with good to excellent enantioselectivities and high activities. In particular, thiophene ketones and furyl ketones furnished 98.6% ee with up to 2.18 x 104(1/h) TOF. This catalytic system was of practical value. In the experiment, the researchers used many compounds, for example, 4-Acetylpyridine(cas: 1122-54-9HPLC of Formula: 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. HPLC of Formula: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Mixed ligand copper(II) chelates derived from an O, N, S- donor tridentate thiosemicarbazone: Synthesis, spectral aspects, FMO, and NBO analysisã€?was published in Polyhedron in 2020. These research results belong to Jacob, Jinsa Mary; Kurup, M. R. Prathapachandra; Nisha, K.; Serdaroglu, Goncagul; Kaya, Savas. Electric Literature of C12H12N2 The article mentions the following:

Five new copper(II) chelates [(Cu(bmct))2] (1), [Cu(bmct)(phen)] (2), [Cu(bmct)(bipy)] (3), [Cu(bmct)(4,4′-dmbipy)] (4) and [Cu(bmct)(5,5′-dmbipy)] (5) with 5-bromo-3-methoxysalicylaldehyde-N(4)-cyclohexylthiosemicarbazone (H2bmct) as the chelating ligand and 1,10-phenanthroline, 2,2′-bipyridine, 4,4′-dimethylbipyridine, 5,5′-dimethylbipyridine as coligands were synthesized and characterized by different physicochem. techniques like CHNS anal., molar conductivity and magnetic studies, IR, UV/Vis and EPR spectral studies. In all the complexes, the thiosemicarbazone exists in thioiminolate form and coordinates to the metal through azomethine nitrogen, thioiminolate sulfur, and phenolate oxygen. EPR spectra in polycrystalline state at 298 K showed that compounds 1, 4, and 5 are isotropic, 2 is axial and 3 is rhombic in nature. In DMF at 77 K, compound 1 showed hyperfine lines in the parallel and perpendicular regions as well as superhyperfine lines due to the interaction of copper center with azomethine nitrogen of the ligand. Complex 2, in which g-II > g âŠ? 2.0023 suggests a distorted square pyramidal structure. To analyze the stability of the complexes, quantum chem. parameters like hardness, softness, polarizability, electrophilicity, electronegativity, and dipole moment were calculated and discussed within the framework of electronic structure principles known as Maximum Hardness, Min. Polarizability and Min. Electrophilicity Principles. Besides, the intramol. donor-acceptor interactions for all complexes were evaluated by using NBO anal. All calculations proved that compound 3 is the most stable chelate among them. After reading the article, we found that the author used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Electric Literature of C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Electric Literature of C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Sensitive Detection of Broad-Spectrum Bacteria with Small-Molecule Fluorescent Excimer Chemosensorsã€?was published in ACS Sensors in 2020. These research results belong to Cabral, Aaron D.; Rafiei, Nafiseh; de Araujo, Elvin D.; Radu, Tudor B.; Toutah, Krimo; Nino, Daniel; Murcar-Evans, Bronte I.; Milstein, Joshua N.; Kraskouskaya, Dziyana; Gunning, Patrick T.. HPLC of Formula: 1539-42-0 The article mentions the following:

Antibiotic resistance is a major problem for world health, triggered by the unnecessary usage of broad-spectrum antibiotics on purportedly infected patients. Current clin. standards require lengthy protocols for the detection of bacterial species in sterile physiol. fluids. A class of small-mol. fluorescent chemosensors termed ProxyPhos is capable of rapid, sensitive, and facile detection of broad-spectrum bacteria. The sensors act via a turn-on fluorescent excimer mechanism, where close-proximity binding of multiple sensor units amplifies a red shift emission signal. ProxyPhos sensors were able to detect down to 10 CFUs of model strains by flow cytometry assays and showed selectivity over mammalian cells in a bacterial coculture through fluorescence microscopy. The studies reveal that the zinc(II)-chelates cyclen and cyclam are novel and effective binding units for the detection of both Gram-neg. and Gram-pos. bacterial strains. Mode of action studies revealed that the chemosensors detect Gram-neg. and Gram-pos. strains with two distinct mechanisms. Preliminary studies applying ProxyPhos sensors to sterile physiol. fluids (cerebrospinal fluid) in flow cytometry assays were successful. The results suggest that ProxyPhos sensors can be developed as a rapid, inexpensive, and robust tool for the “”yes-no”” detection of broad-spectrum bacteria in sterile fluids. In the experiment, the researchers used many compounds, for example, Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0HPLC of Formula: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. HPLC of Formula: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem