Tag: 100-200

In 2022,Yin, Si-Yong; Pan, Chongqing; Zhang, Wen-Wen; Liu, Chen-Xu; Zhao, Fangnuo; Gu, Qing; You, Shu-Li published an article in Organic Letters. The title of the article was 《SCpRh(III)-Catalyzed Enantioselective Synthesis of Atropisomers by C2-Arylation of Indoles with 1-Diazonaphthoquinonesã€?Quality Control of 2-Bromo-5-methylpyridine The author mentioned the following in the article:

The Rh(III)-catalyzed highly enantioselective C2-arylation of indole derivatives with 1-diazonaphthoquinones is reported. In the presence of 2.5 mol % SCpRh complex and 20 mol% AgNO3, the C2-arylation reactions of indoles proceeded smoothly, affording a wide range of C2-arylated indole atropisomers in good yields and enantioselectivity (�6% yield, �7% ee) under mild conditions. The method displays a broad substrate scope and good functional group tolerance. In the experiment, the researchers used many compounds, for example, 2-Bromo-5-methylpyridine(cas: 3510-66-5Quality Control of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Quality Control of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Zhong, Shuai; Zhou, Zhiwei; Zhao, Feng; Mao, Guojiang; Deng, Guo-Jun; Huang, Huawen published an article in Organic Letters. The title of the article was 《Deoxygenative C-S Bond Coupling with Sulfinates via Nickel/Photoredox Dual Catalysisã€?Application of 3510-66-5 The author mentioned the following in the article:

The C-S bond formation from aryl halides and thiols has been well established under various catalytic systems. In this work, user-friendly sulfinates have been exploited as an efficient sulfenylating reagent in the C-S couplings through visible light-induced photo/nickel dual catalysis under base- and external reductant-free conditions. A large number of aryl sulfide products were accessed with high selectivity and high tolerance of various functionalities. After reading the article, we found that the author used 2-Bromo-5-methylpyridine(cas: 3510-66-5Application of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Application of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhu, Huilong; Xing, Junhao; Wu, Changhui; Wang, Chenhong; Yao, Weijun; Dou, Xiaowei published an article in 2022. The article was titled 《Rhodium-Catalyzed Chemodivergent Pyridylation of Alkynes with Pyridylboronic Acidsã€? and you may find the article in Organic Letters.Electric Literature of C5H6BNO2 The information in the text is summarized as follows:

The pyridylation of alkynes with pyridylboronic acids is realized under rhodium catalysis. Chemodivergent pyridylation products, including alkenylpyridines produced via the hydropyridylation pathway and cyclopenta[c]pyridines produced via the pyridylation/cyclization pathway, were selectively produced by fine-tuning the reaction conditions. A mechanistic study revealed that 1,4-rhodium migration to the pyridine ring was involved as the key step in the chemodivergent synthesis. The results came from multiple reactions, including the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Electric Literature of C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Electric Literature of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Weber, Stefan; Bruenig, Julian; Veiros, Luis F.; Kirchner, Karl published their research in Organometallics in 2021. The article was titled 《Manganese-Catalyzed Hydrogenation of Ketones under Mild and Base-free Conditionsã€?Category: pyridine-derivatives The article contains the following contents:

In this paper, several Mn(I) complexes were applied as catalysts for the homogeneous hydrogenation of ketones. The most active precatalyst is the bench-stable alkyl bisphosphine Mn(I) complex fac-[Mn(dippe)(CO)3(CH2CH2CH3)]. The reaction proceeds at room temperature under base-free conditions with a catalyst loading of 3 mol % and a hydrogen pressure of 10 bar. A temperature-dependent selectivity for the reduction of α,β-unsaturated carbonyls was observed At room temperature, the carbonyl group was selectively hydrogenated, while the C:C bond stayed intact. At 60°, fully saturated systems were obtained. A plausible mechanism based on DFT calculations which involves an inner-sphere hydride transfer is proposed. In the experiment, the researchers used many compounds, for example, 4-Acetylpyridine(cas: 1122-54-9Category: pyridine-derivatives)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Xiaoxi; Fan, Shuai; Zhang, Meng; Gao, Yuzhen; Li, Shangda; Li, Gang published their research in Chemical Science in 2021. The article was titled 《Palladium-catalyzed remote para-C-H activation of arenes assisted by a recyclable pyridine-based templateã€?Name: Pyridin-3-ylboronic acid The article contains the following contents:

An unprecedented pyridine-based para-directing template (DT) assisted, Pd-catalyzed para-C-H alkenylation of three classes of arenes, i.e. phenylpropanoic acids, 2-Ph benzoic acids and benzyl alcs., with a series of alkenes included perfluoroalkenes was reported. Notably, the pyridine-based para-DT could be easily synthesized and readily recycled under mild conditions. These results may find application in rapid construction of para-substituted arenes and stimulated the exploration of novel methods for para-C-H functionalization of arenes. In the part of experimental materials, we found many familiar compounds, such as Pyridin-3-ylboronic acid(cas: 1692-25-7Name: Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Name: Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zwergel, Clemens; Di Bello, Elisabetta; Fioravanti, Rossella; Conte, Mariarosaria; Nebbioso, Angela; Mazzone, Roberta; Brosch, Gerald; Mercurio, Ciro; Varasi, Mario; Altucci, Lucia; Valente, Sergio; Mai, Antonello published their research in ChemMedChem in 2021. The article was titled 《Novel Pyridine-Based Hydroxamates and 2-Aminoanilides as Histone Deacetylase Inhibitors: Biochemical Profile and Anticancer Activityã€?Reference of 6-Bromopyridin-3-amine The article contains the following contents:

Starting from the N-hydroxy-3-((4-(2-phenylbutanoyl)amino)phenyl)acrylamide (5 b) previously described by us as a HDAC inhibitor, we prepared four aza-analogs, 6-8, 9 b, as regioisomers containing the pyridine nucleus. Preliminary screening against mHDAC1 highlighted the N-hydroxy-5-((2-(2-phenylbutanoyl)amino)pyridyl)acrylamide (9 b) as the most potent inhibitor. Thus, we further developed both pyridylacrylic- and nicotinic-based hydroxamates (9 a, 9 c-f, and 11 a-f) and 2-aminoanilides (10 a-f and 12 a-f), related to 9 b, to be tested against HDACs. Among them, the nicotinic hydroxamate 11 d displayed sub-nanomolar potency (IC50: 0.5 nM) and selectivity up to 34 000 times that of HDAC4 and from 100 to 1300 times that of all the other tested HDAC isoforms. The 2-aminoanilides were class I-selective HDAC inhibitors, generally more potent against HDAC3, with the nicotinic anilide 12 d being the most effective (IC50HDAC3=0.113μM). When tested in U937 leukemia cells, the hydroxamates 9 e, 11 c, and 11 d blocked over 80% of cells in G2/M phase, whereas the anilides did not alter cell-cycle progress. In the same cell line, the hydroxamate 11 c and the anilide 10 b induced about 30% apoptosis, and the anilide 12 c displayed about 40% cytodifferentiation. Finally, the most potent compounds in leukemia cells 9 b, 11 c, 10 b, 10 e, and 12 c were also tested in K562, HCT116, and A549 cancer cells, displaying antiproliferative IC50 values at single-digit to sub-micromolar level.6-Bromopyridin-3-amine(cas: 13534-97-9Reference of 6-Bromopyridin-3-amine) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Reference of 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Direct Suzuki-Miyaura Coupling with Naphthalene-1,8-diaminato (dan)-Substituted Organoboronsã€?was written by Yoshida, Hiroto; Seki, Michinari; Kamio, Shintaro; Tanaka, Hideya; Izumi, Yuki; Li, Jialun; Osaka, Itaru; Abe, Manabu; Andoh, Hiroki; Yajima, Tomoki; Tani, Tomohiro; Tsuchimoto, Teruhisa. Quality Control of 2-Bromo-5-methylpyridine And the article was included in ACS Catalysis in 2020. The article conveys some information:

The direct Suzuki-Miyaura coupling with “”protected”” R-B(dan) (dan = naphthalene-1,8-diaminato) (R = Ph, 4-MeOC6H4, 2-pyridyl) was demonstrated to smoothly occur without in situ deprotection of the B(dan) moiety. The use of KOt-Bu (Ba(OH)2 in some cases) as a base under anhydrous conditions is the key to the successful cross-coupling, where R-B(dan) is readily converted into a transmetalation-active borate-form, regardless of the well-accepted diminished boron-Lewis acidity. In addition to this study using 2-Bromo-5-methylpyridine, there are many other studies that have used 2-Bromo-5-methylpyridine(cas: 3510-66-5Quality Control of 2-Bromo-5-methylpyridine) was used in this study.

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Quality Control of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Addressing Multiple Ions Using Single Optical Probe: Multi-Color Response via Mutually Independent Sensing Pathwaysã€?was written by Dey, Nilanjan; Bhattacharjee, Subham; Bhattacharya, Santanu. Formula: C6H6BrN And the article was included in ChemistrySelect in 2020. The article conveys some information:

Multiresponsive smart optical probe based on p-phenylene vinylene backbone is designed for simultaneous sensing of multiple ions, such as Cu2+, Zn2+ and F- at pH 7.4. A rapid color change from colorless to deep yellow is observed upon addition of both Cu2+ and Zn2+ ion. However, under long UV lamp, the green-colored emission of the probe is specifically quenched in the presence of Cu2+, while Zn2+ induces change in the emission color from green to yellow. On the contrary, F-, unlike Cu2+ and Zn2+, does not render any change in visible color, however, an emission quenching, similar to that of Cu2+ addition, was noticed. The binding of metal ions to the central bipyridine core diminishes the ′conformational flexibilityâ€?and facilitates ′ligand to metal ionâ€?charge transfer. On the contrary, addition of fluoride triggers the cleavage of silyl ether groups and results in the photo-induced electron transfer from free hydroxyl groups to the core aromatic unit. Thus, we can detect as well as discriminate these three ions (Cu2+, Zn2+ and F-) simultaneously by comparing the resp. output signals. Further, a sustainable strategy has been developed for on-site detection of toxic ions using reusable, low-cost paper strips.2-Bromo-5-methylpyridine(cas: 3510-66-5Formula: C6H6BrN) was used in this study.

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Formula: C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Infrared Spectroscopic Detection of Biosignatures at Lake Tirez, Spain: Implications for Marsã€?was published in Astrobiology in 2020. These research results belong to Preston, Louisa J.; Barcenilla, Rebeca; Dartnell, Lewis R.; Kucukkilic-Stephens, Ezgi; Olsson-Francis, Karen. Computed Properties of C6H5NO2 The article mentions the following:

The detection of potential biosignatures with mineral matrixes is part of a multifaceted approach in the search for life on other planetary bodies. The 2020 ExoMars Rosalind Franklin rover includes within its payload three IR spectrometers in the form of ISEM (IR Spectrometer for ExoMars), MicrOmega, and Ma-MISS (Mars Multispectral Imager for Subsurface Studies). The use of this technique in the detection and characterization of biosignatures is of great value. Organic materials are often co-deposited in terrestrial evaporites and as such have been proposed as relevant analogs in the search for life on Mars. This study focuses on Ca-sulfates collected from the hypersaline Tirez Lake in Spain. Mid IR and visible near IR anal. of soils, salt crusts, and crystals with green and red layering indicative of microbial colonization of the samples was acquired from across the lake and identified the main mineral to be gypsum with inputs of carbonate and silica. Organic functional groups that could be attributed to amides and carboxylic acids were identified as well as chlorophyll; however, due to the strong mineralogical absorptions observed, these were hard to unambiguously discern. Taxonomical assignment demonstrated that the archaeal community within the samples was dominated by the halophilic extremophile Halobacteriaceae while the bacterial community was dominated by the class Nocardiaceae. The results of this research highlight that sulfates on Mars are a mixed blessing, acting as an effective host for organic matter preservation but also a material that masks the presence of organic functional groups when analyzed with spectroscopic tools similar to those due to fly on the 2020 ExoMars rover. A suite of complementary anal. techniques therefore should be used to support the spectral identification of any candidate extraterrestrial biosignatures. The experimental process involved the reaction of Picolinic acid(cas: 98-98-6Computed Properties of C6H5NO2)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Computed Properties of C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Organic Letters included an article by Xie, Haisheng; Shao, Youxiang; Gui, Jiao; Lan, Jianyong; Liu, Zhipeng; Ke, Zhuofeng; Deng, Yuanfu; Jiang, Huanfeng; Zeng, Wei. SDS of cas: 3510-66-5. The article was titled 《Co(II)-Catalyzed Regioselective Pyridine C-H Coupling with Diazoacetatesã€? The information in the text is summarized as follows:

A Co(II)-catalyzed pyridyl C-H bond carbenoid insertion with α-diazoacetates has been realized. This transformation features a highly regioselective C-C bond formation at the C3-position of pyridines, providing an efficient access to diverse α-aryl-α-pyridylacetates. After reading the article, we found that the author used 2-Bromo-5-methylpyridine(cas: 3510-66-5SDS of cas: 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. SDS of cas: 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem