Tag: 100-200

In 2019,Biochemistry included an article by McLeod, Matthew J.; Krismanich, Anthony P.; Assoud, Abdeljalil; Dmitrienko, Gary I.; Holyoak, Todd. Computed Properties of C6H5NO2. The article was titled 《Characterization of 3-[(Carboxymethyl)thio]picolinic Acid: A Novel Inhibitor of Phosphoenolpyruvate Carboxykinaseã€? The information in the text is summarized as follows:

Phosphoenolpyruvate carboxykinase (PEPCK) has traditionally been characterized for its role in the first committed step of gluconeogenesis. The current understanding of PEPCK’s metabolic role has recently expanded to include it serving as a general mediator of tricarboxylic acid cycle flux. Selective inhibition of PEPCK in vivo and in vitro has been achieved with 3-mercaptopicolinic acid (MPA) (Ki âˆ?8μM), whose mechanism of inhibition has been elucidated only recently. On the basis of crystallog. and mechanistic data of various inhibitors of PEPCK, MPA was used as the initial chem. scaffold to create a potentially more selective inhibitor, 3-[(carboxymethyl)thio]picolinic acid (CMP), which has been characterized both structurally and kinetically here. These data demonstrate that CMP acts as a competitive inhibitor at the OAA/PEP binding site, with its picolinic acid moiety coordinating directly with the M1 metal in the active site (Ki âˆ?29-55μM). The extended carboxy tail occupies a secondary binding cleft that was previously shown could be occupied by sulfoacetate (Ki âˆ?82μM) and for the first time demonstrates the simultaneous occupation of both OAA/PEP subsites by a single mol. structure. By occupying both the OAA/PEP binding subsites simultaneously, CMP and similar mols. can potentially be used as a starting point for the creation of addnl. selective inhibitors of PEPCK. The experimental part of the paper was very detailed, including the reaction process of Picolinic acid(cas: 98-98-6Computed Properties of C6H5NO2)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Computed Properties of C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,ChemCatChem included an article by Chan, Vincent S.; Krabbe, Scott W.; Li, Changfeng; Sun, Lijie; Liu, Yue; Nett, Alex J.. Computed Properties of C5H3BrClN. The article was titled 《Identification of an Oxalamide Ligand for Copper-Catalyzed C-O Couplings from a Pharmaceutical Compound Libraryã€? The information in the text is summarized as follows:

The use of pharmaceutical compound library approach in combination with high throughput screening to identify N,N’-bis(thiophene-2-ylmethyl)oxalamide as a ligand that was generally effective for copper-catalyzed C-O cross-couplings to prepare both biarylethers as well as phenols under mild conditions. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloropyridine(cas: 53939-30-3Computed Properties of C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Computed Properties of C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Dalton Transactions included an article by Zhu, Ling; Bai, Yue-Ling; Zhao, Yongmei; Xing, Feifei; Li, Ming-Xing; Zhu, Shourong. Recommanded Product: 1539-42-0. The article was titled 《Bis(2-pyridylmethyl)amine-functionalized alizarin: an efficient and simple colorimetric sensor for fluoride and a fluorescence turn-on sensor for Al3+ in an organic solutionã€? The information in the text is summarized as follows:

A complexone analog chemosensor, H2L, bearing chelating bis(2-pyridylmethyl) amine and alizarin groups was synthesized via the Mannich reaction. H2L chromically responds to OH-, F-, CH3COO-, and H2PO4- in DMF, CH3CN, and acetone, but not in CH3OH or H2O. The addition of F- ions to H2L selectively induces a significant and visible color change in acetonitrile and shifts both methylene proton signals upfield. H2L also exhibits visible responses to Mg2+, Sr2+, Ba2+, Tb3+, Cu2+, Co2+, Ni2+, Zn2+, Mn2+, Cd2+, and Fe3+ in solution AlCl3 can form an Al : L = 2 : 3 complex that not only changes the color of the DMF solution, but also significantly increases its fluorescence intensity. The limit of fluorescence turn-on detection for AlCl3 in DMF is 2.7 × 10-8 M, which is an order higher than those of other anthraquinone sensors reported in the literature. NMR spectroscopy shows that hydroxyl is not deprotonated upon interacting with Al3+, but will be partially deprotonated in the presence of Zn2+. Contrary to the complexone, the H2L-Ce(III) complex does not react chromically to F-. However, the H2L-NiCl2 complex responds chromically to F-, with higher sensitivity (LOD = 1.3 × 10-6 M F- in acetonitrile) than free H2L. The spectral changes in the presence of F- are similar to that of OH-; however, the spectrum shifts slightly to a longer wavelength and is more sensitive to both H2L and the H2L-NiCl2 complex. Moreover, 4% or less H2O in the solvent essentially has no influence on the F- sensitivity; however, high water content significantly decreases the F- sensitivity. The spectral changes of the Zn2+, Cu2+, Fe3+, Ce3+, and Ni2+ complexes in the presence of different NaOH concentrations were also investigated. In the experimental materials used by the author, we found Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Recommanded Product: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Nanjo, Takeshi; Kato, Natsuki; Takemoto, Yoshiji published 《Oxidative Decarboxylation Enables Chemoselective, Racemization-Free Esterification: Coupling of α-Ketoacids and Alcohols Mediated by Hypervalent Iodine(III)ã€?Organic Letters published the findings.Reference of 2-(2-Hydroxyethyl)pyridine The information in the text is summarized as follows:

An α-ketoacid could be converted into a reactive acylating agent by treatment with hypervalent iodine(III) species, and in so doing, a novel decarboxylative acylation of alcs. is discovered that affords a variety of esters in excellent yields. The esterification has been applied to a sterol bearing a free carboxylic acid and shows unique chemoselectivity. The procedure is racemization-free and operates under mild conditions.2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Reference of 2-(2-Hydroxyethyl)pyridine) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cmâˆ?1 (ν19b mode) does not overlap with any of the other bands.Reference of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2013,Nicolas, Lionel; Angibaud, Patrick; Stansfield, Ian; Meerpoel, Lieven; Reymond, Sebastien; Cossy, Janine published 《Copper-catalysed amidation of 2-chloro-pyridinesã€?RSC Advances published the findings.Recommanded Product: 53939-30-3 The information in the text is summarized as follows:

The simple and inexpensive N,N-dimethylcyclohexane-1,2-diamine/CuI catalytic system provides a versatile, easy and efficient access to an array of N-(2-pyridin-2-yl)-amides from 2-chloro-pyridine derivatives In the experimental materials used by the author, we found 5-Bromo-2-chloropyridine(cas: 53939-30-3Recommanded Product: 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Recommanded Product: 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 172152-57-7On October 1, 2021 ,《Regioselective Tandem C-H Alkylation/Coupling Reaction of ortho-Iodophenylethylenes via C,C-Pallada(II)cyclesã€?was published in ACS Catalysis. The article was written by Zhu, Bin-Bin; Ye, Wen-Bo; He, Zhi-Tao; Zhang, Shu-Sheng; Feng, Chen-Guo; Lin, Guo-Qiang. The article contains the following contents:

Five-membered C,C-pallada(II)cycles are a unique class of diorganopalladium species with favorable stability and an electron-rich nature, leading to efficient sequential reactions with diverse electrophiles and nucleophiles. Specifically, the development of aryl-alkenyl-palladacycle-based transformations could provide an attractive approach with regio- and stereocontrol for the construction of multifunctionalized arylethylenes. However, currently, the C,C-pallada(II)cycle formation relies on a rigid skeleton or steric congestion in the backbone to promote cyclopalladation, and the formation of aryl-alkenyl-palladacycle without an α-substituent has not been achieved. Furthermore, reactions that could discriminate between the two sp2 carbon centers of such C(sp2),C(sp2)-palladacycle remain elusive. Herein, a regioselective three-component tandem alkylation/coupling reaction applicable for a variety of non-, α-, or β-substituted and α,β-disubstituted ortho-iodophenylethylenes is reported. Electron-rich 2-pyridone ligands are employed to enable the cyclopalladation process leading to aryl-alkenyl-palladacycle intermediates, of which the two C-Pd bonds are discriminated toward alkylation by their inherent steric and electronic differences. Good linear free-energy relationships between regio-/chemoselectivities and Hammett σ values are observed After reading the article, we found that the author used 2-Chloro-4-methoxy-3-methylpyridine(cas: 172152-57-7Product Details of 172152-57-7)

2-Chloro-4-methoxy-3-methylpyridine(cas: 172152-57-7) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Product Details of 172152-57-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Selective transition metal-free aroylation of diarylmethanes with 2-acyl-imidazolium salts via acyl C-C bond cleavageã€?was written by Zou, Dong; Gan, Li-She; Yang, Fan; Wang, Jia-Min; Li, Lin-Lin; Li, Jie. Formula: C5H6BNO2This research focused ontriarylethanone preparation chemoselective; acyl imidazolium salt diarylmethane aroylation. The article conveys some information:

A highly chemoselective method is reported for the aroylation of simple diarylmethane derivatives Ar1CH2Ar2 (Ar1 = pyridin-4-yl, pyridin-3-yl, furan-2-yl, furan-3-yl, 1-benzofuran-2-yl; Ar2 = Ph, 2-methylphenyl, 4-methoxyphenyl, naphthalen-1-yl, etc.) via direct acyl C-C cleavage with 2-acyl-imidazolium salts I (Ar3 = Ph, 3-methylphenyl, furan-2-yl, naphthalen-2-yl) under transition metal-free conditions. This represents a straightforward way to access a variety of sterically and electronically diverse 1,2,2-triarylethanones Ar3C(O)CHAr1Ar2, a class of compounds with biol. activities and various applications. In the experiment, the researchers used Pyridin-3-ylboronic acid(cas: 1692-25-7Formula: C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Formula: C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C5H6BNO2In 2019 ,《Facile color tuning of thermally activated delayed fluorescence by substituted ortho-carbazole-appended triarylboron emittersã€?was published in Dyes and Pigments. The article was written by Kumar, Ajay; Oh, Jihun; Kim, Juhee; Jung, Jaehoon; Lee, Min Hyung. The article contains the following contents:

We report the facile tuning of the emission color of thermally activated delayed fluorescence (TADF) emitters based on an ortho-carbazole-appended triarylboron. A series of ortho-carbazole-appended triarylboron compounds (2-7) are prepared by introducing various electron-accepting substituents, such as Ph, pyridyl, pyrimidyl, diphenylphosphine oxide, cyano, and dimesitylboryl groups, to the phenylene ring of the dimesitylphenylboryl (PhBMes2) acceptor moiety in the parent ortho-carbazole-appended triarylboron (CzoB, 1). The X-ray crystal structure of the cyano-substituted compound 6 confirms the twisted connectivity between the Cz and phenylene rings. All the compounds exhibit strong TADF (ΦPL = 48-93% in toluene) with large delayed portions. In particular, the emission bands gradually undergo bathochromic shifts from blue (λPL = 463 nm for 1) to greenish yellow (λPL = 532 nm for 7) depending on the electron-accepting substituents. Electrochem. studies show that the greater stabilization of the LUMO level compared to the HOMO is responsible for the red shifts of the emission. Theor. studies further support the observed bathochromic shifts in the emission, as well as the small energy splittings (ΔEST) between the excited singlet and triplet states that afford the efficient TADF. In the experimental materials used by the author, we found Pyridin-3-ylboronic acid(cas: 1692-25-7COA of Formula: C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. COA of Formula: C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C5H7N3In 2021 ,《Sensing a binding event through charge transport variations using an aromatic oligoamide capsuleã€?was published in Chemical Science. The article was written by Mateus, Pedro; Jacquet, Antoine; Mendez-Ardoy, Alejandro; Boulloy, Alice; Kauffmann, Brice; Pecastaings, Gilles; Buffeteau, Thierry; Ferrand, Yann; Bassani, Dario M.; Huc, Ivan. The article contains the following contents:

The selective binding properties of a 13-mer oligoamide foldamer capsule composed of 4 different aromatic subunits are reported. The capsule was designed to recognize dicarboxylic acids through multiple-point interactions owing to a combination of protonation/deprotonation events, H-bonding, and geometrical constraints imparted by the rigidity of the foldamer backbone. Compared to tartaric acid, binding of 2,2-difluorosuccinic acid or 2,2,3,3-tetrafluorosuccinic acid resulted in symmetry breaking due to deprotonation of only one of the two carboxylic acid groups of the encapsulated species as shown by NMR studies in solution and by single-crystal X-ray diffraction in the solid state. An analogous 14-mer foldamer capsule terminated with a thiol anchoring group was used to probe the complexation event in self-assembled monolayers on Au substrates. Ellipsometry and polarization-modulation IR absorption-reflection spectroscopy studies were consistent with the formation of a single mol. layer of the foldamer capsule oriented vertically with respect to the surface. The latter underwent smooth complexation of 2,2-difluorosuccinic acid with deprotonation of one of the two carboxylic acid groups. A significant (80-fold) difference in the charge transport properties of the monolayer upon encapsulation of the dicarboxylic acid was evidenced from conducting-AFM measurements (S = 1.1 x 10-9vs. 1.4 x 10-11 ohm-1 for the empty and complexed capsule, resp.). The modulation in conductivity was assigned to protonation of the aromatic foldamer backbone. In the experimental materials used by the author, we found 2,6-Diaminopyridine(cas: 141-86-6COA of Formula: C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.COA of Formula: C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1122-54-9In 2022 ,《Tailoring the molecular structure of pyridine-based polymers for enhancing performance of anion exchange electrolyte membranesã€?appeared in Renewable Energy. The author of the article were Xu, Shicheng; Wu, Wanlong; Wan, Ruiying; Wei, Wei; Li, Yujiao; Wang, Jin; Sun, Xiaoqi; He, Ronghuan. The article conveys some information:

Anion exchange membranes (AEMs) with high ionic conductivity and excellent chem. stability are desired for relevant electrochem. devices. We designed and prepared pyridine based ether free poly (biphenyl pyridine) (PBP) membranes by modifying pyridinium with both hydrophilic and hydrophobic end groups via the Menshutkin reaction. The grafted Et tri-Me ammonium and hexyl pendants assisted the formation of well-connected ion transport channels in the membranes according to the results of transmission electron microscopy (TEM). The highest conductivity of 117 mS cm-1 to hydroxide ions and 73 mS cm-1 to bromide ions was achieved, resp., at 90 °C by the prepared membranes. The conductivity retention rate of the AEMs was within 84-93% after soaking in 1 mol L-1 KOH at 80 °C for 1008 h. The membrane-based single fuel cell exhibited an open circuit voltage of 0.99 V and a peak power d. of 241 mW cm-2 at 80 °C by fueling with humidified H2 and O2 without backpressure. The aqueous zinc bromine battery with a composite separator of the polymer impregnated glass fiber achieved 92.6% of the coulombic efficiency. The assembled battery retained 98% of initial capacity after 157 cycles at a c.d. of 6 mA cm-2. In the experiment, the researchers used many compounds, for example, 4-Acetylpyridine(cas: 1122-54-9Related Products of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Related Products of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem