Tag: 100-200

The author of 《Diacetyl as a “”traceless”” visible light photosensitizer in metal-free cross-dehydrogenative coupling reactionsã€?were Huang, Chia-Yu; Li, Jianbin; Liu, Wenbo; Li, Chao-Jun. And the article was published in Chemical Science in 2019. Reference of 4-Cyanopyridine The author mentioned the following in the article:

Minisci alkylation is of prime importance for its applicability in functionalizing diverse heteroarenes, which are core structures in many bioactive compounds In alkyl radical generation processes, precious metal catalysts, high temperatures and excessive oxidants are generally involved, which lead to sustainability and safety concerns. Herein a new strategy using diacetyl (2,3-butanedione) as an abundant, visible light-sensitive and “”traceless”” hydrogen atom abstractor to achieve metal-free cross-dehydrogenative Minisci alkylation under mild conditions is reported. Mechanistic studies supported hydrogen atom transfer (HAT) between an activated C(sp3)-H substrate and diacetyl. Moreover, with the assistance of di-tert-Bu peroxide (DTBP), the scope of the reaction could be extended to strong aliphatic C-H bonds via diacetyl-mediated energy transfer. The robustness of this strategy was demonstrated by functionalizing complex mols. such as quinine, fasudil, nicotine, menthol and alanine derivatives In the experiment, the researchers used 4-Cyanopyridine(cas: 100-48-1Reference of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Reference of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Palladium-Catalyzed Electrochemical C-H Alkylation of Arenesã€?were Yang, Qi-Liang; Li, Chuan-Zeng; Zhang, Liang-Wei; Li, Yu-Yan; Tong, Xiaofeng; Wu, Xin-Yan; Mei, Tian-Sheng. And the article was published in Organometallics in 2019. Related Products of 3510-66-5 The author mentioned the following in the article:

2-Arylpyridines were electrochem. ortho-alkylated by RBF3K, the reaction being performed in undivided cell in aqueous solutions catalyzed by Pd(OAc)2. Palladium-catalyzed electrochem. C-H functionalization reactions have emerged as attractive tools for organic synthesis. This process offers an alternative to conventional methods that require harsh chem. oxidants. However, this electrolysis requires divided cells to avoid catalyst deactivation by cathodic reduction Herein, we report the first example of palladium-catalyzed electrochem. C-H alkylation of arenes using undivided electrochem. cells in water, thereby providing a practical solution for the introduction of alkyl group into arenes. The experimental process involved the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Related Products of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Organic Letters included an article by Xia, Peng-Ju; Ye, Zhi-Peng; Hu, Yuan-Zhuo; Song, Dan; Xiang, Hao-Yue; Chen, Xiao-Qing; Yang, Hua. Recommanded Product: 197958-29-5. The article was titled 《Photocatalytic, Phosphoranyl Radical-Mediated N-O Cleavage of Strained Cycloketone Oximesã€? The information in the text is summarized as follows:

In the presence of the iridium photocatalyst [Ir[dF(CF3)ppy]2(dtbbpy)]PF6, four-membered cyclic ketoximes such as cyclobutanone oxime underwent ring opening and addition reactions with aryl alkenes such as 1,1-diphenylethylene or with α-trifluoromethylstyrenes such as PhC(CF3):CH2 mediated by Ph3P (via its photogenerated phosphoranyl radical cation) under blue LED light to yield 6-arylhexanenitriles such as Ph2CH(CH2)4CN or (aryl)(difluoromethylene)hexanenitriles such as F2C:CPh(CH2)4CN. In the part of experimental materials, we found many familiar compounds, such as 2-Pyridinylboronic acid(cas: 197958-29-5Recommanded Product: 197958-29-5)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Recommanded Product: 197958-29-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Mohammad, Akbar; Ansari, Shagufi Naz; Chaudhary, Archana; Ahmad, Khursheed; Rajak, Richa; Tauqeer, Mohd.; Mobin, Shaikh M. published 《Enthralling Adsorption of Different Dye and Metal Contaminants from Aqueous Systems by Cobalt/Cobalt Oxide Nanocomposites Derived from Single-Source Molecular Precursorsã€?ChemistrySelect published the findings.SDS of cas: 103-74-2 The information in the text is summarized as follows:

The cobalt/cobalt oxide nanocomposites (Co/CoO NCs), NC-1 and NC-2 were synthesized from our recently reported single-source mol. precursors (SSMPs) [Co(hep-H)(H2O)4]SO4, (1) and [Co(hep-H)2(H2O)2](NO3)2, (2), [hep-H= 2-(2-hydroxylethyl) pyridine], resp., via wet-chem. reduction method. Our purpose was to study the effect of different counter anions (i. e. SO42- and NO3-) of precursors on the surface properties of synthesized materials. Both the nanocomposites were characterized by Powder X-ray diffraction (PXRD), SEM (SEM), energy-dispersive X-ray anal. (EDAX), transmission electron microscopy (TEM), Fourier transform IR (FTIR) spectroscopy and Brunauer-Emmett-Teller (BET) anal. Two distinct morphol. as well as surface features have been obtained using 1 and 2 viz. variable spheres (NC-1) with low surface area and flakes (NC-2) with high surface area. The adsorption behavior of these nanocomposites on industrial dyes and heavy metals showed excellent dye adsorption (99.6% to 97.2%) and good to moderate metal adsorption efficiency of NC-1. The NC-1 could be recycled up to five times for dyes and three times for metals, advocating its practical applications in industry. The experimental process involved the reaction of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2SDS of cas: 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. SDS of cas: 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Chotsaeng, Nawasit; Laosinwattana, Chamroon; Charoenying, Patchanee published 《Inhibitory effects of a variety of aldehydes on Amaranthus tricolor L. and Echinochloa crus-galli (L.) Beauv.ã€?Molecules published the findings.Recommanded Product: 128071-75-0 The information in the text is summarized as follows:

Thirty-seven com. aldehydes containing aliphatic chains and aromatic rings as well as heteroaromatic rings were evaluated for their inhibitory activities against Chinese amaranth (Amaranthus tricolor L.) and barnyardgrass (Echinochloa crus-galli (L.) Beauv). Polysorbate 80 (Tween@ 80) was used as a surfactant and the research was preliminarily conducted at 400 μM of all aldehydes. Among these aldehydes, (E)-cinnamaldehyde (7) showed the greatest inhibitory effect on seed germination, shoot and root growth of Chinese amaranth by 54.55%, 75.53%, and 85.13% resp. Similarly, (E)-crotonaldehyde (5), a related α,β-unsaturated aldehyde, inhibited the germination and seedling growth of the tested species at a high percentage. Apart from these two unsaturated aldehydes, no other aliphatic aldehydes had a harmful effect on Chinese amaranth. In terms of benzaldehyde (6), it had no effect on the tested plant; however, many of its derivatives displayed some inhibitory activity. Furthermore, for the ten common heteroaromatic aldehydes, picolinaldehyde (32) had a high inhibitory effect on Chinese amaranth which closely related to the effect of (E)-crotonaldehyde (5) and (E)-cinnamaldehyde (7), whereas, other heteroaromatic aldehydes showed lower effects. In the case of a monocot plant, barnyardgrass, no tested aldehydes reduced seed germination, however, (E)-cinnamaldehyde (7), 2,4,6-trimethoxybenzaldehyde (16) and 4-(dimethylamino)benzaldehyde (24) could inhibit the seedling growth of the plant with low to moderate levels. The herbicidal effects of the most active aldehydes were then further investigated in order to find the min. concentration of these aldehydes suppressing the germination and growth of the tested plants. At concentrations as low as 50-100 μM some aldehydes could inhibit the seedling growth of the tested species. The structure-activity relationship (SAR) study reported here demonstrates the chem. clues governing the inhibitory activity of aldehydes which could be utilized in the development of highly effective herbicides in the near future. In the part of experimental materials, we found many familiar compounds, such as 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Feng, Xiujuan; Li, Lingyu; Yu, Xiaoqiang; Yamamoto, Yoshinori; Bao, Ming published 《Copper-catalyzed conversion of aryl and heteroaryl bromides into the corresponding iodideã€?Catalysis Today published the findings.Name: 6-Bromopyridin-3-amine The information in the text is summarized as follows:

An efficient method for the synthesis of aryl iodides RI (R = 4-H3CC6H4, 1-naphthyl, 4-H3CC(O)C6H4, etc.) and heteroaryl iodides, R1I (R1 = quinolin-3-yl, 5-fluoro-pyridin-2-yl, thiophen-3-yl, etc.) has been described. The reactions of aryl bromides such as 1-bromo-4-methyl-benzene, 1-bromonaphthalene, 1-bromo-4-chloro-benzene, etc. and heteroaryl bromides such as 2-bromo-pyridine, 3-bromo-thiophene, 6-bromo-nicotinonitrile, etc. with potassium iodide proceeded smoothly in the presence of a copper catalyst under mild reaction conditions to produce the corresponding iodides in satisfactory to excellent yields. The experimental process involved the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9Name: 6-Bromopyridin-3-amine)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Name: 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Hyde, Alan M.; Liu, Zhijian; Kosjek, Birgit; Tan, Lushi; Klapars, Artis; Ashley, Eric R.; Zhong, Yong-Li; Alvizo, Oscar; Agard, Nicholas J.; Liu, Guiquan; Gu, Xiuyan; Yasuda, Nobuyoshi; Limanto, John; Huffman, Mark A.; Tschaen, David M. published 《Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reductionã€?Organic Letters published the findings.Electric Literature of C5H3BrClN The information in the text is summarized as follows:

A scalable and efficient synthesis of the GPR40 agonist MK-8666 was developed from a simple pyridine building block. The key step to set the stereochem. at two centers relied on an enzymic dynamic kinetic reduction of an unactivated ketone. Directed evolution was leveraged to generate an optimized ketoreductase that provided the desired trans alc. in >30:1 dr and >99% ee. Further, it was demonstrated that all four diastereomers of this hydroxy-ester could be prepared in high yield and selectivity. Subsequently, a challenging intramol. displacement was carried out to form the cyclopropane ring system with perfect control of endo/exo selectivity. The endgame coupling strategy relied on a Pd-catalyzed C-O coupling to join the headpiece chloropyridine with the benzylic alc. tailpiece. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3Electric Literature of C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Electric Literature of C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2014,Lafaye, Kevin; Nicolas, Lionel; Guerinot, Amandine; Reymond, Sebastien; Cossy, Janine published 《Lewis Basicity Modulation of N-Heterocycles: A Key for Successful Cross-Metathesisã€?Organic Letters published the findings.Reference of 5-Bromo-2-chloropyridine The information in the text is summarized as follows:

Introducing a chloro or other substituent neighboring the nitrogen atom of azaheterocycle-containing alkenes decreased their Lewis basicity sufficiently that, in most cases, they underwent olefin cross-metathesis with alkenes such as Me acrylates and (Z)-2-butene-1,4-diol diacetate in the presence of the second-generation Hoveyda-Grubbs ruthenium metathesis catalyst to give azaheteroaryl-substituted alkenes diastereoselectively. A variety of electron-deficient and electron-rich olefins and styrenes underwent metathesis, while chloro-, bromo-, fluoro-, trifluoromethyl-, trifloxy-, methoxy-, and tert-butyl-substituted pyridinylalkenes and chloro-substituted pyrimidinyl, isoquinolinyl, imidazolyl, and pyrazolyl alkenes were effective metathesis substrates. The experimental process involved the reaction of 5-Bromo-2-chloropyridine(cas: 53939-30-3Reference of 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Reference of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Catalytic enantioselective borane reduction of benzyl oximes: preparation of (S)-1-pyridin-3-yl-ethylamine bis hydrochlorideã€?were Huang, Kun; Ortiz-Marciales, Margarita. And the article was published in Organic Syntheses in 2010. Quality Control of (S)-1-(Pyridin-3-yl)ethanamine dihydrochloride The author mentioned the following in the article:

The enantioselective preparation of (S)-1-(pyridin-3-yl)ethylamine bis hydrochloride is achieved by chiral spiroborate ester-catalyzed borane reduction of (E)-1-(pyridin-3-yl)ethanone O-benzyl-oxime in 88% yield, and 94% ee. In the part of experimental materials, we found many familiar compounds, such as (S)-1-(Pyridin-3-yl)ethanamine dihydrochloride(cas: 40154-84-5Quality Control of (S)-1-(Pyridin-3-yl)ethanamine dihydrochloride)

(S)-1-(Pyridin-3-yl)ethanamine dihydrochloride(cas: 40154-84-5) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 â†?R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Quality Control of (S)-1-(Pyridin-3-yl)ethanamine dihydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Visible-Light-Mediated C-H Alkylation of Pyridine Derivativesã€?was written by Rammal, Fatima; Gao, Di; Boujnah, Sondes; Gaumont, Annie-Claude; Hussein, Aqeel A.; Lakhdar, Sami. Quality Control of 4-CyanopyridineThis research focused onvisible light alkylation pyridine derivative alkane. The article conveys some information:

We report herein a visible-light-mediated C-H alkylation of pyridine derivatives that proceeds by simple combination of a large variety of N-alkoxypyridinium ions with alkanes in the presence of 2 mol % of fac-Ir(ppy)3 under blue illumination. The mild reaction conditions together with the high group functional tolerance make of this process a useful synthetic platform for the construction of structurally strained heterocycles. Detailed mechanistic investigations, including d. functional theory calculations and quantum yield measurement, allowed us to understand factors controlling the reactivity and the selectivity of the reaction. The results came from multiple reactions, including the reaction of 4-Cyanopyridine(cas: 100-48-1Quality Control of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Quality Control of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem