Tag: 100-200

Panish, Robert; Thieu, Tho; Balsells, Jaume published their research in Organic Letters in 2021. The article was titled 《Copper-Catalyzed Synthesis of 5-Carboxyl-4-perfluoroalkyl Triazoles》.Category: pyridine-derivatives The article contains the following contents:

A facile, scalable synthesis of previously inaccessible trifluoromethyl and perfluoroalkyl triazoles is disclosed. Mediated by copper, this catalytic protocol enables access to 4-perfluoroalkyl triazoles from commodity chems. A catalytic Cu(II) system wherein copper serves two roles (generation of N-tosyl-2-vinyldiazenes and N-N bond formation) allows for rapid assembly of 5-carboxyl-4-perfluoroalkyl-triazoles from N-tosylhydrazide and perfluoroalkyl acetoacetates. Et 4,4,4-trifluoro-3-(2-tosylhydrazineylidene)butanoate, a previously unknown air and bench stable reagent for access to CF3-triazoles, was developed to enable this chem. This led to the identification of a series of crystalline hydrazone reagents that could be used as templates to construct an array of triazoles. Hydrolysis and decarboxylation parlay this approach into a means to access 5-H-4-CF3-triazoles. The approach exhibits high functional group tolerance and can be executed on a multigram scale. In addition to this study using 2-Bromo-5-methylpyridine, there are many other studies that have used 2-Bromo-5-methylpyridine(cas: 3510-66-5Category: pyridine-derivatives) was used in this study.

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ma, Cui-Cui; Zhu, Xing-Xing; Liu, Li; Dai, Jian-Jun; Xu, Jun; Xu, Hua-Jian published their research in Tetrahedron Letters in 2021. The article was titled 《Synthesis of polyfluorinated aromatic ethers and thioethers by synergistic cleavage of C-B bond and C-F bond of B(C6F5)3》.Category: pyridine-derivatives The article contains the following contents:

A concise and efficient method for the synthesis of polyfluorinated aromatic ethers 2,3,5,6-F4C6HOR (R = 3-nitrophenyl, 1-naphthyl, quinolin-5-yl, etc.) and thioethers 2,3,5,6-F4C6HSR1 (R1 = benzyl, cyclohexyl, naphth-2-yl, etc.) by synergistic cleavage of C-B bond and C-F bond of B(C6F5)3 is reported. The reaction could proceed smoothly with excellent functional-group compatibility. In addition, the transformation represents the first general application of B(C6F5)3 as reaction partners in cross-coupling reaction. In the experimental materials used by the author, we found 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Category: pyridine-derivatives)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Type I photosensitizers based on phosphindole oxide for photodynamic therapy: apoptosis and autophagy induced by endoplasmic reticulum stress》 was written by Zhuang, Zeyan; Dai, Jun; Yu, Maoxing; Li, Jianqing; Shen, Pingchuan; Hu, Rong; Lou, Xiaoding; Zhao, Zujin; Tang, Ben Zhong. HPLC of Formula: 2510-22-7 And the article was included in Chemical Science in 2020. The article conveys some information:

Photodynamic therapy is considered a pioneering and effective modality for cancer treatment, but it is still facing challenges of hypoxic tumors. Recently, Type I PDT, as an effective strategy to address this issue, has drawn considerable attention. Few reports are available on the capability for Type I reactive oxygen species (ROS) generation of purely organic photosensitizers (PSs). Herein, we report two new Type I PSs, α-TPA-PIO and β-TPA-PIO, from phosphindole oxide-based isomers with efficient Type I ROS generation abilities. A detailed study on photophys. and photochem. mechanisms is conducted to shed light on the mol. design of PSs based on the Type I mechanism. The in vitro results demonstrate that these two PSs can selectively accumulate in a neutral lipid region, particularly in the endoplasmic reticulum (ER), of cells and efficiently induce ER-stress mediated apoptosis and autophagy in PDT. In vivo models indicate that β-TPA-PIO successfully achieves remarkable tumor ablation. The ROS-based ER stress triggered by β-TPA-PIO-mediated PDT has high potential as a precursor of the immunostimulatory effect for immunotherapy. This work presents a comprehensive protocol for Type I-based purely organic PSs and highlights the significance of considering the working mechanism in the design of PSs for the optimization of cancer treatment protocols. In the experimental materials used by the author, we found 4-Ethynylpyridine(cas: 2510-22-7HPLC of Formula: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. HPLC of Formula: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Asymmetrically difunctionalized dibenzo[b,d]furan-based hole blocking materials for high-performance blue phosphorescent organic light-emitting diodes》 was published in Dyes and Pigments in 2020. These research results belong to Hong, Soojin; Chung, Won Jae; Jang, Seokhoon; Yu, Gyeonghwa; Lee, Jun Yeob; Lee, Youngu. Category: pyridine-derivatives The article mentions the following:

Three new hole blocking materials based on asym. difunctionalized dibenzo[b,d]furan, diphenyl(2-(pyridin-3-yl)dibenzo[b,d]furan-6-yl)phosphine oxide (DBFPO-Py), diphenyl(2-(pyrimidin-5-yl)dibenzo[b,d]furan-6-yl)phosphine oxide (DBFPO-Pyr), and diphenyl(2-(4-(triphenylsilyl)phenyl)dibenzo[b,d]furan-6-yl)phosphine oxide (DBFPO-Si) were designed and synthesized for high-performance phosphorescent OLEDs. Phosphine oxide, tetraphenylsilane, pyridine, and pyrimidine segments are introduced into the asym. position of a dibenzo[b,d]furan. DBFPO-Py, DBFPO-Pyr, and DBFPO-Si possess high thermal stability; high triplet energies of 2.96, 2.98, and 2.80 eV; and deep HOMO energy levels of -7.13, -7.23 and -7.07 eV;, resp. Blue phosphorescent OLEDs with DBFPO-Py, DBFPO-Pyr, and DBFPO-Si show low turn-on voltages, high current and power efficiencies, and superior external quantum efficiencies. Blue phosphorescent OLEDs with DBFPO-Py and DBFPO-Pyr showed improved performance in terms of current and power efficiencies, etc., compared with the device with 1,3-bis(3,5-dipyrid-3-yl-phenyl)benzene (BmPyPB), which is commonly used as a hole blocking layer. The blue phosphorescent OLEDs with DBFPO-Pyr showed the best performance with maximum external quantum efficiency of 23.6%, current efficiency of 29.8 cd A-1, power efficiency of 26.0 lm W-1, and low efficiency roll-off of 6.38%. Hole blocking materials based on asym. difunctionalized dibenzo[b,d]furan are expected to make a significant contribution to the development of blue phosphorescent OLEDs. The experimental part of the paper was very detailed, including the reaction process of Pyridin-3-ylboronic acid(cas: 1692-25-7Category: pyridine-derivatives)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Tuning layered superstructures in precision polymers》 was published in Scientific Reports in 2020. These research results belong to Danke, Varun; Reimann, Sophie; Binder, Wolfgang H.; Gupta, Gaurav; Beiner, Mario. Product Details of 141-86-6 The article mentions the following:

An approach to influence and control layered superstructures by varying the methylene sequence length between two consecutive functional groups in linear precision polymers containing 2,6-diaminopyridine (DAP) groups is presented. Layered superstructures with repeating units involving three monomeric units along the chain direction with very high coherence lengths upto 110 nm are observed in case of shorter alkyl segments, (16 and 18 CH2 units), while more conventional layer superstructures incorporating only one monomer are found for related polymers with 20 CH2 units per methylene sequence. A building block model explaining the unusually large periodicity of three monomeric units is proposed wherein layers containing crystalline or amorphous methylene sequences occur in different combinations. Occurrence of different layered structures depending on crystallization conditions, methylene sequence length as well as functional group type is explained by a competition of H-interactions between the DAP groups and the van der Waal forces between the hydrophobic methylene groups. In the experimental materials used by the author, we found 2,6-Diaminopyridine(cas: 141-86-6Product Details of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Product Details of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Organic-Inorganic Hybrid Cerium-Encapsulated Selenotungstate Including Three Building Blocks and Its Electrochemical Detection of Dopamine and Paracetamol》 was published in Inorganic Chemistry in 2020. These research results belong to Jiang, Jun; Liu, Lulu; Liu, Guoping; Wang, Dan; Zhang, Yan; Chen, Lijuan; Zhao, Junwei. Product Details of 1692-25-7 The article mentions the following:

A novel organic-inorganic hybrid cerium-encapsulated selenotungstate comprising three polyoxotungstate building units Na16H6{[Ce3W4O10(H2O)9(CH3COO)3]2(Se2W7O30)(B-α-SeW9O33)4}·(C5H8NBO3)·119H2O (1) was synthesized by the portfolio approach of an in situ self-assembly reaction and step-by-step synthesis. The hybrid polyoxoanion of 1 is constructed from an acetate-coordinated heterometallic {[(Ce3W4O10)(H2O)9(CH3COO)3]2(Se2W7O30)}10+ core encompassing four trilacunary [B-α-SeW9O33]8- subunits. Interestingly, the heterometallic core contains a remarkable [Se2W7O30]10- building block in which seven WVI atoms form a W7 plane and two SeIV atoms are situated on two opposite faces of the W7 plane. In addition, the electrochem. performances of the 1@CFMCN composite (CFMCN: carboxyl-functionalized multiwalled carbon nanotube) were investigated. The 1@CFMCN/GCE (GCE: glass carbon electrode) sensor demonstrates a promising potential in electrochem. sensing dopamine (DPA) or paracetamol (PCM) or even simultaneously detecting DPA and PCM with low limits of 0.053μM for DPA and 2.03μM for PCM over a wide linear range at high sensitivity. A novel organic-inorganic hybrid selenotungstate was synthesized via the portfolio approach of an in situ self-assembly reaction and step-by-step synthesis. Its electrochem. sensing properties toward DPA and PCM were investigated. In addition to this study using Pyridin-3-ylboronic acid, there are many other studies that have used Pyridin-3-ylboronic acid(cas: 1692-25-7Product Details of 1692-25-7) was used in this study.

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Product Details of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Pyridyl CO2 Fixation Enabled by a Secondary Hydrogen Bonding Coordination Sphere》 was published in ACS Omega in 2020. These research results belong to Gayton, Jacqueline N.; Li, Qing; Sanders, Lakeeta; Rodrigues, Roberta R.; Hill, Glake; Delcamp, Jared H.. SDS of cas: 141-86-6 The article mentions the following:

Reversible CO2 binders under ambient conditions are of significant interest for multiple applications in sensing and capture technologies. In this paper, a general systematic way to evaluate CO2 receptors with π-systems is put forward. A series of receptors (five pyridine-based and one triazine-based) are evaluated as CO2 binders in terms of number of hydrogen bonding sites, strength of hydrogen bond donors, and number of nucleophilic sites. The binding of CO2 to the receptors was probed by computational models, absorption spectroscopy, fluorescence spectroscopy, cyclic voltammetry, and 1H NMR studies. Multiple solvents with varying ionic strength additives are probed to analyze the effects on CO2-bound intermediates. The receptors were screened progressively down-selecting through the different anal. techniques arriving at a promising pyridine receptor, which shows evidence of CO2 binding with each of the anal. techniques. The diaminopyridine motif demonstrates reversible CO2 binding and has convenient substitution sites for derivatization to incorporate into functional sensor systems. In the part of experimental materials, we found many familiar compounds, such as 2,6-Diaminopyridine(cas: 141-86-6SDS of cas: 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.SDS of cas: 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Iron-catalyzed remote functionalization of inert C(sp3)-H bonds of alkenes via 1,n-hydrogen-atom-transfer by C-centered radical relay》 was published in Chemical Science in 2020. These research results belong to Bian, Kang-Jie; Li, Yan; Zhang, Kai-Fan; He, Yan; Wu, Tian-Rui; Wang, Cheng-Yu; Wang, Xi-Sheng. Recommanded Product: 2-(2-Hydroxyethyl)pyridine The article mentions the following:

Enabled by 1,n (n = 5, 6)-hydrogen atom transfer (HAT), a most prevalent moiety, alkene, as the precursor to an sp3 C-centered radical to promote selective cleavage of inert C(sp3)-H bonds for the generation of azidotrifluoromethylated mols. I [R1 = Me, n-Bu, Ph, etc.; R2 = H, Me, Et, n-octyl; R1R2 = (CH2)3, (CH2)4, (CH2)2O(CH2)2, etc.; X = C(CO2Et)2, C(CH2OBz)2, NTs] was used. Mild conditions, broad scope and excellent regioselective control (>20 : 1) were observed in the reactions. Deuterium labeling studies disclosed the kinetic characteristics of the transformations and verify a direct 1,n-HAT pathway. The key to this C-centered radical relay was that iron played a dual role as a radical initiator and terminator to incorporate the azide functionality through radical oxidation via azido-ligand-transfer. The methods and the later derivatization promised expeditious synthesis of CF3-containing organic azides, γ-lactam and triazoles that were widely used in designing new fluorescent tags and functional materials. In the experiment, the researchers used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Recommanded Product: 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Recommanded Product: 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Synthesis and characterization of a novel 18F-labeled 2,5-diarylnicotinamide derivative targeting orexin 2 receptor》 were Watanabe, Hiroyuki; Matsushita, Naoki; Shimizu, Yoichi; Iikuni, Shimpei; Nakamoto, Yuji; Togashi, Kaori; Ono, Masahiro. And the article was published in MedChemComm in 2019. Quality Control of Pyridin-3-ylboronic acid The author mentioned the following in the article:

Orexin 2 receptor (OX2R) is thought to play an important role in the arousal-promoting function, but its distribution and function in the pathophysiol. of orexin-mediated disorders remains to be fully elucidated. In the present study, we synthesized and characterized a novel 18F-labeled 2,5-diarylnicotinamide (DAN) derivative as a potential positron emission tomog. (PET) probe for in vivo imaging of OX2R. In in vitro binding experiments, [18F]DAN-1 selectively bound to OX2R. In a biodistribution study using normal mice, [18F]DAN-1 displayed moderate brain uptake (2.10% ID per g at 10 min post-injection). In addition, the radioactivity in the mouse brain at 30 min post-injection was significantly decreased by co-injection with nonradioactive DAN-1, but high nonspecific binding was observed These results suggested that further structural modifications of [18F]DAN-1 are needed to use it for imaging OX2R in the brain. In the part of experimental materials, we found many familiar compounds, such as Pyridin-3-ylboronic acid(cas: 1692-25-7Quality Control of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Quality Control of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Synthesis and biological properties of tetranuclear ruthenium complexes containing the bis[4(4′-methyl-2,2′-bipyridyl)]-1,7-heptane ligand》 were Sun, Biyun; Sundaraneedi, Madhu K.; Southam, Hannah M.; Poole, Robert K.; Musgrave, Ian F.; Keene, F. Richard; Collins, J. Grant. And the article was published in Dalton Transactions in 2019. Reference of 4,4′-Dimethyl-2,2′-bipyridine The author mentioned the following in the article:

Linear and non-linear tetranuclear ruthenium(II) complexes containing the bridging ligand bis[4(4′-methyl-2,2′-bipyridyl)]-1,7-heptane have been synthesized and their biol. properties examined The min. inhibitory concentrations (MIC) and the min. bactericidal concentrations (MBC) of the ruthenium(II) complexes were determined against six strains of bacteria: Gram-pos. Staphylococcus aureus (S. aureus) and methicillin-resistant S. aureus (MRSA); and the Gram-neg. Escherichia coli (E. coli) strains MG1655, APEC, UPEC and Pseudomonas aeruginosa (P. aeruginosa). The results showed that both tetranuclear complexes had significant antimicrobial activity, with the non-linear (branched) species (Rubb7-TNL) having slightly higher activity than the corresponding linear analog (Rubb7-TL). The corresponding toxicity against three eukaryotic cell lines – BHK (baby hamster kidney), Caco-2 (heterogeneous human epithelial colorectal adenocarcinoma) and Hep-G2 (liver carcinoma) – have also been determined Interestingly, both Rubb7-TNL and Rubb7-TL were as toxic to the eukaryotic cells as they were to the bacteria, a rarity for kinetically-inert cationic polypyridylruthenium(II) complexes, and exhibited lower IC50 values than cisplatin over 24-, 48- or 72-h incubation times. Fluorescence spectroscopy was used to study the binding of the ruthenium complexes with human serum albumin (HSA). Rubb7-TNL and Rubb7-TL exhibited strong HSA binding, with equilibrium binding constants in the order of 107 M-1. Confocal microscopy was used to examine the cellular localization of Rubb7-TNL in BHK cells. The results indicated that the ruthenium complex localized in the nucleolus. Significant accumulation was also observed in the cytoplasm, but not in the mitochondria. Taken together, the results of this study suggest that Rubb7-TNL is an unlikely candidate as an antimicrobial agent, but may have potential as an anticancer drug.4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Reference of 4,4′-Dimethyl-2,2′-bipyridine) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Reference of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem